Results 91 to 100 of about 1,831,672 (338)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
The Journal of Engineering, 2014 It has been shown in two earlier papers published from this study that corresponding to a given single-operational trans-conductance amplifier (single-OTA)-RC and dual-OTA-RC sinusoidal oscillators, there are three other structurally distinct equivalent ...
Raj Senani +3 more
doaj +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Existence and stability of solutions for nonlinear Mecking-Lucke-Grilhe equations
Electronic Journal of Differential Equations, 2011 In this article, we present the nonlinear Mecking-Lucke-Grilhe model describing the temporal evolution for simple and multi-instabilities of plastic deformation of stressed monocristal. This model extends the linear problem considered in [9, 13, 14].
Ali Alriyabi, Said Hilout
doaj
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Characteristic form of boost-invariant and cylindrically asymmetric hydrodynamic equations [PDF]
, 2006 Mikołaj Chojnacki, Wojciech Florkowski
openalex +1 more source
Conservation Equations and Characteristics
, 2016 A conservation law for a physical system states that a certain quantity (e.g., mass, energy, or momentum) is independent of time. For continuous systems such as fluids or gases, these global quantities can be defined as integrals of density functions. The conservation law then translates into a local form, as a PDE for the density function.
openaire +1 more source