Results 141 to 150 of about 305,820 (298)

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Morphological and DNA Sequence Data of Two New Millipede Species of the Thyropygus induratus Subgroup (Diplopoda: Spirostreptida: Harpagophoridae)

, 2023
The common cylindrical millipede genus Thyropygus (family Harpagophoridae) comprises four informal species groups, one of which is the T. allevatus group. This group is characterized by two synapomorphic gonopodal characters: (1) gonopods with tibial and
Enghoff, Henrik, Pimvichai, Piyatida, Backeljau, Thierry   +2 more
core  

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan, Mustafa Subhi, Elaina Luskin, Bryan Quah, Sreekanth Madhusoodhanan Nair, Arzu C. Has Silemek, Gabriela Zabala, Yujie Cui, Laura Locke, Paula Barreras, Marwa Kaisey, Vinicius Calsavara, Daniel S. Reich, Nancy L. Sicotte, Pascal Sati, Omar Al‐Louzi   +17 more
wiley   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Molecular mechanisms underlying the MiT translocation subgroup of renal cell carcinomas.

, 2007
Contains fulltext : 34461.pdf (Publisher’s version ) (Closed access) Contains fulltext : 36461.pdf (Author’s version preprint ) (Open Access)Renal cell carcinomas (RCCs) represent a ...
Hurk, W.H. van den, Kuiper, R.P., Geurts van Kessel, A.H.M., Medendorp, K., Groningen, J.J.M. van, Schoenmakers, E.F.P.M., Schepens, M.T.M., Basten-Vreede, L.A.J., Thijssen, J.   +8 more
core   +1 more source

A characterization on separable subgroups of 3‐manifold groups

Journal of Topology, 2019
In this paper, we give a complete characterization on which finitely generated subgroups of finitely generated $3$-manifold groups are separable. Our characterization generalizes Liu's spirality character on $π_1$-injective immersed surface subgroups of closed $3$-manifold groups.
openaire   +4 more sources

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source

Measuring polarization by reduced-form indices [PDF]

An abbreviated or reduced-form monotonic polarization index is an increasing function of the between-group term and a decreasing function of the within-group term of a population subgroup decomposable inequality index.
Bhargav Maharaj, Satya R. Chakravarty
core  

ΔNp73 isoform defines a TP53-mutant-like poor-risk subgroup of acute myeloid leukemia [PDF]

Among acute myeloid leukemia (AML) patients, a subgroup remains notoriously refractory to current treatment options, with underlying mechanisms poorly understood.
van den Boom, Vincent, Pereira-Martins, Diego A, Mojallali, Fatemeh, Hogeling, Shanna M, Schuringa, Jan Jacob, Sternadt, Dominique, Bianco, Thiago M, Ammatuna, Emanuele, Huls, Gerwin, Weinhäuser, Isabel, Rego, Eduardo M, Ortiz, Cesar, Chatzikyriakou, Prodromos; id_orcid, Lucena-Araujo, Antonio R, Silveira, Douglas R; id_orcid, Quek, Lynn, Wierenga, Albertus T J, van der Meer, Nisha K   +17 more
core   +1 more source

Expression profiling of adult acute lymphoblastic leukemia identifies a BCR-ABL1-like subgroup characterized by high non-response and relapse rates

Haematologica, 2015
Judith M. Boer, Jasper E. Koenders, Bronno van der Holt, Carla Exalto, Mathijs A. Sanders, Jan J. Cornelissen, Peter J.M. Valk, Monique L. den Boer, Anita W. Rijneveld   +8 more
doaj   +1 more source