Results 131 to 140 of about 305,820 (298)
A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective
In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager +7 morewiley +1 more sourceMolecular Classification of Malignant Pleural Mesothelioma: Identification of a Poor Prognosis Subgroup Linked to the Epithelial-to-Mesenchymal Transition
, 2014 International audiencePURPOSE:Despite research efforts to develop more effective diagnostic and therapeutic approaches, malignant pleural mesothelioma (MPM) prognosis remains poor.Imbeaud, Sandrine, Renier, Annie, Elarouci, Nabila, Le Pimpec-Barthes, Françoise, de Reyniès, Aurélien, Galateau-Salle, Françoise, Petel, Fabien, Zucman-Rossi, Jessica, Andujar, Pascal, Hofman, Paul, Jaurand, Marie-Claude, Cazes, Aurélie, Hysi, Ilir, Jean, Didier, Couchy, Gabrielle +14 morecore +1 more sourcePosterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective
Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.Yuttachai Likitjaroen, Ya‐Ting Chang, Levinia Lim, Pai‐Yi Chiu, Jung‐Lung Hsu, SangYun Kim, Wataru Narita, Na Young Ryoo, Kyoko Suzuki, Nagaendran Kandiah, Sebastian Crutch, Ming‐Chyi Pai +11 morewiley +1 more sourceNeurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm [PDF]
Machine learning can be used to define subtypes of psychiatric conditions based on shared biological foundations of mental disorders. Here we analyzed cross-sectional brain images from 4,222 individuals with schizophrenia and 7038 healthy subjects pooled Tang Y., Fuentes-Claramonte P., van Erp T. G. M., Iasevoli F., Preda A., Huang H., Hahn T., Xiang S., Rodrigue A. L., Yang J., Spaniel F., Liu Z., Kircher T., Burhanoglu B. B., Grotegerd D., Homan S., Van Rheenen T. E., Jahanshad N., Duan M., Yu X., Hughes M., Usemann P., Spalletta G., Brunetti A., Gaser C., Gonul A. S., Calhoun V. D., Quide Y., Park M. T. M., Sponheim S. R., Wang J., de Bartolomeis A., Fernandez-Cabello S., Garcia-Leon M. A., Cocozza S., Glahn D., Chung Y. C., Vecchio D., Jiang Y., Rossell S. L., Lin C. -P., Stein F., Carruthers S. P., Nemoto K., Skoch A., Zhang T., Thomopoulos S. I., Cheng J., Cecere G., Salvador R., Kirschner M., Palaniyappan L., Cui L. -B., Uslu O., Rootes-Murdy K., Dannlowski U., Miura K., Andreassen O. A., Thomas-Odenthal F., Teutenberg L., Meinert S., Yao D., Zhang J., Luo C., Barone A., Thompson P. M., Kim W. -S., Chang X., Pomarol-Clotet E., Piras F., Richard G., Kaiser S., Nguyen D. D., Woods W., Ciccarelli M., Georgiadis F., Tsai S. -J., Omlor W., Parker N., Zhang Y., Demro C., Uyar Demir A., Karuk A., Nenadic I., Blangero J., Green M., Zhou E., Sim K., Pontillo G., Westlye L. T., Ringin E., Feng J., Lencer R., Pearlson G., Ramsay I. S., Banaj N., Tranfa M., Hashimoto R., Yue W., Li C., Cheng W., Sumner P., Homan P., Tomecek D., Turner J. A. +104 morecore +2 more sourcesA Systematic Review and Meta‐Analysis of the Recurrence of Autoimmune Encephalitis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective
Autoimmune encephalitis (AE) is a disease with a potential for recurrence, and patients receive immunotherapy to prevent it. However, there is no consensus on the duration of immunotherapy. This study aimed to determine the recurrence rate and identify the risk factors for AE to provide guidance on the duration of immunotherapy ...Shangkai Bai, Sen Zhang, Haipei Zhang, Yating Zhang, Junhong Guo, Xiaoyan Yang +5 morewiley +1 more sourceMultidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective
Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano +28 morewiley +1 more sourceGNAS-activating mutations define a rare subgroup of inflammatory liver tumors characterized by STAT3 activation.
, 2012 International audienceBACKGROUND & AIMS: Mosaic G-protein alpha-subunit (GNAS)-activating mutations are responsible for the McCune-Albright (MCA) syndrome.Jean-Yves Scoazec, Bioulac-Sage, Paulette, Sophie Prevot, Jean Charles Nault, Marie-José Redon, Nault, Jean Charles, Balabaud, Charles, Prevot, Sophie, de Muret, Anne, Zucman-Rossi, Jessica, Jessica Zucman-Rossi, Tran van Nhieu, Jeanne, Saint-Paul, Marie-Christine, Emmanuelle Jeannot, Chanson, Philippe, Charles Balabaud, Catherine Buffet, Couchy, Gabrielle, Scoazec, Jean-Yves, Redon, Marie-José, Gabrielle Couchy, Marie-Christine Saint-Paul, Paulette Bioulac-Sage, Salenave, Sylvie, Jeannot, Emmanuelle, Anne De Muret, Camilla Pilati, Pilati, Camilla, Buffet, Catherine, Monique Fabre, Jeanne Tran Van Nhieu, Labrune, Philippe, Fabre, Monique, Philippe Chanson, Sylvie Salenave, Philippe Labrune +35 morecore +1 more sourceConcomitant parasite infections influence tuberculosis immunopathology and favor rapid sputum conversion of pulmonary tuberculosis patients
Annals of Clinical Microbiology and AntimicrobialsImmunopathology of human tuberculosis (TB) in a subgroup of patients is characterized by aberrantly high concentrations of inflammatory cytokines, for example Interleukin (IL)-6.Augustine Yeboah, Monikamira Vivekanandan, Ernest Adankwah, Dorcas O. Owusu, Wilfred Aniagyei, Difery Minadzi, Isaac Acheampong, Joseph F. Arthur, Millicent Lamptey, Mohammed K. Abass, Francis Kumbel, Francis Osei-Yeboah, Amidu Gawusu, Linda Batsa Debrah, Alexander Debrah, Ertan Mayatepek, Julia Seyfarth, Richard O. Phillips, Marc Jacobsen +18 moredoaj +1 more source