Results 111 to 120 of about 305,820 (298)

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Molecular profiling of long-term survivors identifies a subgroup of glioblastoma characterized by chromosome 19/20 co-gain

, 2015
Glioblastoma (GBM) is a devastating tumor and few patients survive beyond 3 years. Defining the molecular determinants underlying long-term survival is essential for insights into tumor biology and biomarker identification.
Bäcklund, L. Magnus, Lahrmann, Bernd, Mittelbron, Michel, Grabe, Niels, Warta, Rolf, Geisenberger, Christoph, Schwager, Christian, Korshunov, Andrey, Debus, Jürgen, Schnabel, Elena, Rapp, Carmen, Jungk, Christine, Nied, Ann-Katrin, Mock, Andreas, Pfister, Stefan M., Zheng, Siyuan, Abdollahi, Amir, Verhaak, Roel G. W., Unterberg, Andreas, Collins, V. Peter, Herold-Mende, Christel, Hartmann, Christian, von Deimling, Andreas, Jones, David, Capper, David, Brors, Benedikt, Ichimura, Koichi   +26 more
core   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Agathidium dentigerum Subgroup

, 2005
<i>Agathidium dentigerum</i> Subgroup <p>DISCUSSION: This group of species is characterized by the operculum of the median lobe completely divided into two long, independent rami (e.g., fig.
MILLER, KELLY B., WHEELER, QUENTIN D.
core   +1 more source

Stratifying vascular disease patients into homogeneous subgroups using machine learning and FLAIR MRI biomarkers

npj Imaging
This study proposes a framework to stratify vascular disease patients based on brain health and cerebrovascular disease (CVD) risk using regional FLAIR biomarkers.
Karissa Chan, Corinne Fischer, Pejman Jabehdar Maralani, Sandra E. Black, Alan R. Moody, April Khademi   +5 more
doaj   +1 more source

Subgroups based on autoantibody status associated with clinical manifestations, HLA-DRB1 variants, cytokines, and flare of vasculitis in childhood-onset systemic lupus erythematosus

Frontiers in Immunology
ObjectiveChildhood-onset systemic lupus erythematosus (cSLE) exhibits significant heterogeneity, leading to challenges in prognosis and treatment. This study aims to stratify cSLE patients into clinically distinct subgroups based on routine autoantibody ...
Shengfang Bao, Shengfang Bao, Jingyi Lu, Jiani Ma, Yingying Jin, Hua Huang, Zhen Yang, Xuemei Xu, Chenxi Liu, Xiqiong Han, Liping Wang, Sun Chen, Yufeng Li, Yanliang Jin   +13 more
doaj   +1 more source

Distinct gene expression signatures induced by viral transactivators of different HTLV-1 subgroups that confer a different risk of HAM/TSP

Retrovirology, 2018
Background Among human T cell leukemia virus type 1 (HTLV-1)-infected individuals, there is an association between HTLV-1 tax subgroups (subgroup-A or subgroup-B) and the risk of HAM/TSP in the Japanese population.
Tadasuke Naito, Jun-ichirou Yasunaga, Yuichi Mitobe, Kazumasa Shirai, Hiroe Sejima, Hiroshi Ushirogawa, Yuetsu Tanaka, Tatsufumi Nakamura, Kousuke Hanada, Masahiro Fujii, Masao Matsuoka, Mineki Saito   +11 more
doaj   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

Discovery of Function in the Enolase Superfamily: d‑Mannonate and d‑Gluconate Dehydratases in the d‑Mannonate Dehydratase Subgroup

, 2015
The continued increase in the size of the protein sequence databases as a result of advances in genome sequencing technology is overwhelming the ability to perform experimental characterization of function.
Daniel J. Wichelecki (1317042), Steven C. Almo (198342), Elena V. Fedorov (1317024), Tiit Lukk (1317045), Bryan M. Balthazor (1317021), Anthony C. Chau (1317027), John A. Gerlt (1306377), Ronald D. Seidel (583757), Yury V. Patskovsky (1317039), Brandan S. Hillerich (1317036), Matthew W. Vetting (583760), Mark B. Stead (1317030), Alexander A. Fedorov (1317033)   +12 more
core   +1 more source

A characterization of the subgroups of the additive rationals [PDF]

Pacific Journal of Mathematics, 1951
Beaumont, Ross A., Zuckerman, H. S.
openaire   +3 more sources