Results 101 to 110 of about 87,063 (285)

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Rare manifestation of a c.290 C\u3eT, p.Gly97Glu VCP mutation [PDF]

, 2015
Introduction. The valosin-containing protein (VCP) regulates several distinct cellular processes. Consistent with this, VCP mutations manifest variable clinical phenotypes among and within families and are a diagnostic challenge. Methods.
Chou, Tsui-Fen, Crockett, Cameron D, Gonzalez, Michael A, Grider, Tiffany, Jerath, Nivedita U, Moore, Steven A, Shy, Michael E, Swenson, Andrea, Weihl, Conrad C, Zuchner, Stephan   +9 more
core   +4 more sources

Comparative Outcomes of Percutaneous Needle Tenotomy Performed by a Podiatrist Versus an Orthopaedic Surgeon in the Management of Toe Ulcers

Journal of Foot and Ankle Research, Volume 19, Issue 1, March 2026.
ABSTRACT Background Foot ulceration is a debilitating and often disabling complication of diabetes mellitus, with negative prognostic associations in terms of morbidity and mortality. Percutaneous needle tenotomy (PNT) is increasingly recognized as a safe, minimally invasive procedure for treating tendon‐related deformities, including mechanical ...
Adrian Heald, Sangeeth Priyadarshan Veluchamy Rathakrishnan, Jessica Blong, Andrew Sharpe, Andy Gorman, Edward Jude, Mike Stedman, Adam Robinson, Neil D. Reeves, Edward Gee, Matthew Allen   +10 more
wiley   +1 more source

Preclinical translational platform of neuroinflammatory disease biology relevant to neurodegenerative disease

Journal of Neuroinflammation
Neuroinflammation is a key driver of neurodegenerative disease, however the tools available to model this disease biology at the systems level are lacking.
Kelley C. Larson, Lauren H. Martens, Michael Marconi, Christopher Dejesus, Suzanne Bruhn, Thomas A. Miller, Barbara Tate, Jonathan M. Levenson   +7 more
doaj   +1 more source

High levels of anxiety and depression in diabetic patients with Charcot foot

Journal of Foot and Ankle Research, 2014
Background/aims Charcot foot is a rare but devastating complication of diabetes. Little research is available on the mental health impact of Charcot foot.
Zahra Chapman, Charles Matthew James Shuttleworth, Jörg Wolfgang Huber   +2 more
doaj   +1 more source

Treatment of Charcot Neuroarthropathy and osteomyelitis of the same foot: a retrospective cohort study

BMC Musculoskeletal Disorders, 2017
Background We evaluated treatment of osteomyelitis in the foot in the presence of Charcot neuroarthropathy, a devastating condition with progressive degeneration and joint destruction.
Martin Berli, Lazaros Vlachopoulos, Sabra Leupi, Thomas Böni, Charlotte Baltin   +4 more
doaj   +1 more source

Restoring mitofusin balance prevents axonal degeneration in a Charcot-Marie-Tooth type 2A model [PDF]

, 2019
Mitofusin-2 (MFN2) is a mitochondrial outer-membrane protein that plays a pivotal role in mitochondrial dynamics in most tissues, yet mutations in MFN2, which cause Charcot-Marie-Tooth disease type 2A (CMT2A), primarily affect the nervous system.
A.K.M.G. Muhammad, Antonietta Franco, Bergamin, Bin Lu, Burté, Cartoni, Cathleen M. Lutz, Chung, El Fissi, Gerald W. Dorn, Guyenet, Jesse Landeros, Lee, Michael Vazquez, Ritchie Ho, Robert H. Baloh, Rouzier, Santel, Santel, Shaomei Wang, Sharon Carmona, Shaughn Bell, Verhoeven, Yueqin Zhou   +23 more
core   +2 more sources

Healing through empowerment and active listening (HEALing): A mixed‐methods evaluation of the feasibility and acceptability of a nurse‐led self‐care support intervention for people with diabetic foot ulcers

Diabetic Medicine, Volume 43, Issue 3, March 2026.
Abstract Aims To evaluate the feasibility, acceptability, and implementation of HEALing (Healing through Empowerment and Active Listening)—a clinic‐integrated self‐care intervention delivered by trained wound care nurses in three 30‐min face‐to‐face sessions over 6 weeks to support diabetic foot ulcer healing. Methods A mixed‐methods, single‐arm hybrid
Xiaoli Zhu, Eng Sing Lee, Frederick H. F. Chan, Ruoyu Yin, Phoebe X. H. Lim, Rachel W. S. Koh, Carpenter Judith, Voon Hooi Lim, Richard S. Y. Low, Jie Su, Faridah Binte Mohamad Yusoff, Yee Chui Chen, Konstadina Griva   +12 more
wiley   +1 more source

Quantitative Assessment of Type-1 Collagen in Charcot Neuroarthropathy with Use of Harmonic Generation and Multiphoton Microscopy

Foot & Ankle Orthopaedics, 2018
Category: Diabetes Introduction/Purpose: Diabetic Charcot neuroarthropathy is characterized by rapid loss of bone with accompanied disruption to the surrounding joints and is often in the absence of trauma or infection. Previous research has demonstrated
Kaitlin Saloky BS, Michael Aynardi MD, Kempland Walley BS, Paul Juliano MD, Heather Matchik PA, Thomas Abraham PhD   +5 more
doaj   +1 more source

Charcot’s triad [PDF]

QJM: An International Journal of Medicine, 2020
V H Chong, C F Chong, S Y Tan
openaire   +2 more sources