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The Charcot Foot in Diabetes [PDF]

Diabetes Care, 2011
The diabetic Charcot foot syndrome is a serious and potentially limb-threatening lower-extremity complication of diabetes. First described in 1883, this enigmatic condition continues to challenge even the most experienced practitioners. Now considered an inflammatory syndrome, the diabetic Charcot foot is characterized by varying degrees of bone and ...
Rogers, Lee C., Frykberg, Robert G., Armstrong, David G., Boulton, Andrew J M, Edmonds, Michael, Ha Van, Georges, Hartemann, Agnes, Game, Frances, Jeffcoate, William, Jirkovska, Alexandra, Jude, Edward, Morbach, Stephan, Morrison, William B., Pinzur, Michael, Pitocco, Dario, Sanders, Lee, Wukich, Dane K., Uccioli, Luigi, Rogers, LC, Frykberg, RG, Armstrong, DG, Van, GH, Morrison, WB, Wukich, DK   +23 more
core   +20 more sources

Risk of Venous Thromboembolism in People Affected by Charcot Foot Treated With Total Contact Cast. [PDF]

J Foot Ankle Res
ABSTRACT Aims Charcot Foot (CF) is a neuropathy‐induced condition that can lead to fractures and dislocation, warranting long‐time offloading in total contact cast (TCC). It is unknown whether CF or its treatment increases the risk of venous thromboembolism (VTE).
Schoug J, Katzman P, Uddman E, Löndahl M.   +3 more
europepmc   +2 more sources

Charcot foot disease: A new approach. [PDF]

Drugs Aging
Charcot neuropathic osteoarthropathy (CNO) is a condition that develops in the presence of neuropathy, most commonly diabetes-related neuropathy. Owing to the neuropathy, microtrauma to the bones occur without the individual feeling them. With continued walking, bone inflammation, resorption, microfractures and structural changes occur in the bones ...
Dubský M, Bém R, Sojáková D, Fejfarová V, Hughes M, Jude EB.   +5 more
europepmc   +4 more sources

Risk factors for Charcot foot development in individuals with diabetes mellitus [PDF]

Diabetologia
Neda Rajamand Ekberg, Sergiu Catrina, Tove Fall   +2 more
exaly   +2 more sources

Acute Charcot foot [PDF]

BMJ, 2012
#### Key points A 38 year old man was referred by his general practitioner to our diabetes foot clinic with a swollen red foot (fig 1⇓). He had had type 1 diabetes for 25 years, complicated with retinopathy, peripheral neuropathy, and nephropathy, and was being worked up for dialysis following a failed pancreas-kidney transplant.
Piero, Baglioni, Manzar, Malik, Onyebuchi E, Okosieme   +2 more
openaire   +2 more sources

Genetic Variants of Na+,K+‐ATPase Associated With Neurological Disorders: A Systematic Review

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Neurological disorders encompass a wide range of severe symptoms and manifestations, many of which are associated with genetic variants that affect ionic homeostasis. Na+,K+‐ATPase, a transmembrane enzyme responsible for maintaining electrochemical gradients in cells, plays a crucial role in neuronal excitability and brain function.
Giovana Kummer da Rosa, Leandro Rodrigo Ribeiro, Jéssica Lorena Bariviera, Mauro Schneider Oliveira   +3 more
wiley   +1 more source

Establishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded Murine ATXN3

Annals of Neurology, EarlyView.
Repeat expansion disorders frequently involve peripheral neuropathy, yet mechanisms remain unclear. Using a spinocerebellar ataxia type 3 (SCA3) Knock‐In Atxn3Q300/Q6, we identify progressive sensorimotor deficits, peripheral nerve pathology, and dorsal root ganglia RNA splicing dysregulation.
Juan P. Mato, John M. Hayes, Jacen Emerson, Maeha Sridharan, Toluwani Adelaja, Arsal Naeem, Alexandra F. Putka, Hayley S. McLoughlin   +7 more
wiley   +1 more source

A Case of Distal Hereditary Motor Neuronopathy‐7 With Two Novel VWA1 Variants in Compound Heterozygosity

Neurology and Clinical Neuroscience, EarlyView.
ABSTRACT Distal hereditary motor neuronopathy‐7 (HMNR7) is an autosomal recessive VWA1‐related disorder characterized predominantly by distal motor involvement. A 41‐year‐old man with a history of childhood orthopedic surgery for foot deformities exhibited progressive distal weakness and muscle atrophy with lower limb predominance. Electrophysiological
Toshiyuki Kakumoto, Kenta Orimo, Takashi Matsukawa, Jun Mitsui, Shoji Tsuji   +4 more
wiley   +1 more source

Evaluating the effectiveness and acceptability of an animated educational tool for diabetic foot care: A randomized controlled trial and mixed‐methods study in patients with active, in‐remission and high‐risk diabetic foot disease

Journal of Diabetes Investigation, EarlyView.
A bespoke educational animation led to improvements in diabetic foot self‐care knowledge in a cohort of 52 patients living with high‐risk diabetic foot disease who were attending a hospital‐based podiatry clinic in this exploratory pilot randomized controlled and mixed‐methods study.
Michael Lockhart, Jack Cosgrave, Pir Zainulabdeen Jan Sarhandi, Kellie Fortune, Eimear Daly, Tommy Kyaw Tun, Colin Davenport, Seamus Sreenan, Derek T O'Keeffe, John H McDermott   +9 more
wiley   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source