Results 21 to 30 of about 308,984 (157)

Frequency and Circumstances of Falls Events in People Living With Spinal and Bulbar Muscular Atrophy: A Cross‐Sectional Survey

Physiotherapy Research International, Volume 31, Issue 4, October 2026.
ABSTRACT Background and Purpose Spinal and bulbar muscular atrophy (SBMA) is an adult‐onset X‐linked neuromuscular disorder associated with progressive weakness, sensory involvement and impaired mobility. Falls appear frequent in SBMA, but their real‐world frequency and circumstances have not been systematically described.
Laurence E. Lee, Luca Zampedri, Dipa Jayaseelan, Carlo Rinaldi, Pietro Fratta, Gita M. Ramdharry   +5 more
wiley   +1 more source

Charcot Foot Ulceration [PDF]

, 2012
This case report follows the treatment of a 64 year old male with a Charcot foot ulceration of the right foot. The study was conducted to assess the outcome of wound care to the stage three pressure ulcer and the use of a Total Contact Cast (TCC) in the ...
SIEVERT, KATELIN
core   +1 more source

Monoallelic POLR3A Variants Cause Early‐Onset Peripheral Neuropathy

Annals of Neurology, Volume 100, Issue 3, Page 655-671, September 2026.
Objective Biallelic variants in genes encoding the RNA polymerase III complex (Pol III) cause a spectrum of neurological disorders primarily affecting the central nervous system. Monoallelic variants have been reported in the POLR3B subunit only, associated with neurodevelopmental disorder, epilepsy, and peripheral neuropathy.
Luiza L. P. Ramos, Jevin M. Parmar, Robin Wijngaard, Bianca R. Grosz, Tamas Lazar, Ligia Mateiu, Steve Vucic, Kishore R. Kumar, Dennis Yeow, Laura I. Rudaks, Lonneke de Boer, Annemarie de Vreugd, David A. Koolen, Thatjana Gardeitchik, Anita Cairns, Krishnan Iyengar, Fernando Kok, Fernanda Barbosa Figueiredo, Alzira Alves de Siqueira Carvalho, Luiz S. Mageste Barbosa, Rodrigo Rezende Arantes, Tyler Rehbein, Jordan E. Bontrager, Elizabeth P. Wood, Janet E. Sowden, Gavin Monahan, Meutia Kumaheri, Ivy Cuijt, Melina Ellis, Gonzalo Perez‐Siles, Elyshia McNamara, Ronald van Beek, Celine B. Meijers, Ivaylo Tournev, Stephan Zuchner, Shoshana J. Wodak, Clara D. M. van Karnebeek, Nigel Laing, Liana N. Semcesen, David A. Stroud, David N. Herrmann, Velina Guergueltcheva, Marina L. Kennerson, Machteld M. Oud, Gianina Ravenscroft, Ayse Candayan, Albena Jordanova   +46 more
wiley   +1 more source

Moth‐Eaten Osteolysis of Multiple Foot Bones After a Conservatively Treated “Stable” Ankle Fracture: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Progressive multifocal “moth‐eaten” osteolysis involving foot and ankle bones after nonoperative treatment of a stable ankle fracture is rare and warrants evaluation for infectious, neoplastic, inflammatory, vascular, and mechanical causes.
Haotian Wu, Xue Yang, Yao Zhou, Zihan Chen, Liqing Yao   +4 more
wiley   +1 more source

Recent Advancements in Drug Delivery Across the Blood–Brain Barrier in Amyotrophic Lateral Sclerosis (ALS)

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Progressive BBB/BSCB dysfunction is increasingly recognized as both a pathological feature and a therapeutic barrier in ALS. Novel delivery technologies and barrier‐restoration strategies may enhance CNS drug exposure, improve the efficacy of disease‐modifying therapies, and advance ALS treatment. ABSTRACT Background Amyotrophic lateral sclerosis (ALS)
Nitesh Sanghai, Kaitlyn Pierce, Nidhi Sharma, Sasha Leggett, Tara Chand Yadav, Pegah Masrori, Devi Atukorallaya, Senthilnathan Palaniyandi, Paul C. Marcogliese, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

When Glycaemic Control Comes Too Fast: Treatment‐Induced Neuropathy of Diabetes and Charcot Neuro‐Osteoarthropathy as Emerging Iatrogenic Complications of Rapid Metabolic Correction

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.
ABSTRACT Purpose of Review Diabetes therapeutics can lower glycated haemoglobin (HbA1c) by several percentage points within weeks. While long‐term microvascular risk is reduced by improved glycaemia, abrupt metabolic transitions may destabilise tissues adapted to chronic hyperglycemia.
Dured Dardari
wiley   +1 more source

Long‐Term Mortality in Diabetic Foot Disease is Higher Than That of Overall Cancer: Results From Three International Cohorts

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.
ABSTRACT Background Guidelines suggest that the risk of mortality in diabetic foot disease (DFD) is comparable to that of cancer; however, high‐quality evidence is lacking. We aimed to compare the mortality of DFD with that of various cancers based on data from international cohorts.
Qinglian Zeng, Ziwei Tang, Xiangjun Chen, Linlin Zhan, Victoria Balasubramanian, Zhihao Chen, Manman Du, Qi Zhang, Fei Lian, Xiaoru Zhang, Qing Liang, Wenrui Zhao, Xun Li, Mengyao Zhang, Qifu Li, Shumin Yang, Jinbo Hu, Qingfeng Cheng, Hang Shen   +18 more
wiley   +1 more source

Global Epidemiology of Diabetic Foot: A Systematic Review and Meta‐Analysis

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.
ABSTRACT Introduction Diabetic foot (DF) disease, including ulcerations, amputations, and infections, represents a major cause of morbidity and mortality in individuals with diabetes mellitus (DM). Despite their substantial clinical, social, and economic burden, robust global epidemiological estimates remain limited due to fragmented evidence and ...
Massimo Carollo, Ylenia Ingrasciotta, Salvatore Crisafulli, Francesco Maccarrone, Daniela Pellegrino, Alberto Francescon, Edoardo Mannucci, Andrea Fontana, Gianluca Trifirò   +8 more
wiley   +1 more source

The Rhythmic and the Metronomic: On Charlie Chaplin's Gait

Critical Quarterly, EarlyView.
Matthew Beaumont
wiley   +1 more source

Ultrasonography Cannot Exclude Osteomyelitis in Diabetic Foot Ulcers: A Cross‐Sectional Diagnostic Accuracy Study Against Magnetic Resonance Imaging

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
Ultrasound is a valuable first‐line imaging tool for diabetic foot soft‐tissue infection but cannot reliably exclude osteomyelitis. MRI remains the preferred modality for evaluating suspected bone involvement. ABSTRACT Background and Aims Diabetic foot ulcers (DFUs) can lead to amputation, especially when complicated by osteomyelitis (OM) or soft ...
Maryam Haghighi‐Morad, Hadi Vahedi, Arian Yousefi Fard, Behrooz Mohammadkhani Pordanjani, Seyyed Taher Seyyed Mahmoudi   +4 more
wiley   +1 more source