Results 21 to 30 of about 253 (210)

CID fragmentation, H/D exchange and supermetallization of Barnase-Barstar complex

Scientific Reports, 2017
The barnase-barstar complex is one of the most stable protein-protein complexes and has a very wide range of possible applications. Here we report the use of top-down mass spectrometry for the investigation of the structure of this complex, its ...
Yury Kostyukevich, Aleksej A. Shulga, Alexey Kononikhin, Igor Popov, Eugene Nikolaev, Sergey Deyev   +5 more
doaj   +1 more source

On the ion and electron temperature recovery after the ELM-crash at ASDEX upgrade

Nuclear Materials and Energy, 2019
The access to fast measurements, i.e. Δt ≈ 100 µs, of the ions and the electrons during an entire edge localized cycle (ELM) reveals asymmetries in the recovery of the maximum edge gradients.
M. Cavedon, R. Dux, T. Pütterich, E. Viezzer, E. Wolfrum, M. Dunne, E. Fable, R. Fischer, G.F. Harrer, F.M. Laggner, A.F. Mink, U. Plank, U. Stroth, M. Willensdorfer, ASDEX Upgrade Team   +14 more
doaj   +1 more source

Testing a prediction model for the H-mode density pedestal against JET-ILW pedestals

Nuclear Fusion, 2023
The neutral ionisation model proposed by Groebner et al (2002 Phys. Plasmas 9 2134) to determine the plasma density profile in the H-mode pedestal, is extended to include charge exchange processes in the pedestal stimulated by the ideas of Mahdavi et al (
S. Saarelma, J.W. Connor, P. Bilkova, P. Bohm, A.R. Field, L. Frassinetti, R. Fridstrom, A. Kirk, JET Contributors   +8 more
doaj   +1 more source

Tracking the Rapid Opening and Closing of Polar Coronal Holes through IBEX ENA Observations

The Astrophysical Journal, 2023
Fast solar wind (SW) flows outward from polar coronal holes (PCHs). The latitudinal extent of the fast SW varies during different phases of the solar cycle. The fast SW in the inner heliosheath produces a flatter proton spectrum than the slow SW that can
Bishwas L. Shrestha, Eric J. Zirnstein, David J. McComas   +2 more
doaj   +1 more source

Multi-electron ionization and charge exchange in heavy ion fusion

Journal of Physics: Conference Series, 2008
Together with space-charge neutralization, ionization and charge exchange in the heavy ion beam fusion (HIBF) chamber can change beam quality and final focusing. Our research here supports simulation of these interactions through exploring theoretical approaches and developing improved models. This study is focused on the multi-electron processes which
L Wu, G H Miley
openaire   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The Excited State and Charge Transfer of Two Nonfullerene Acceptors from First-Principles Many-Body Green’s Function Theory

Journal of Chemistry, 2022
Nonfullerene acceptors (NFAs) have shown an outstanding performance upon producing highly efficient and sustainable organic solar cells (OSC). Recently, a growing group of researchers denoted to modify the structures of acceptor−donor−acceptor-type NFAs ...
Xinyue Bai, Guokui Liu, Yunzhi Li, Guangli Zhou, Xia Leng, Qiying Xia, Yaoyao Wei   +6 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Efficiency of δ-Tocopherol in Inhibiting Lipid Oxidation in Emulsions: Effects of Surfactant Charge and of Surfactant Concentration

Antioxidants, 2023
Charged interfaces may play an important role in the fate of chemical reactions. Alterations in, for instance, the interfacial acidity of emulsions induced by the charge of the surfactant head group and associated counterions may change the ionization ...
Tamara Martínez-Senra, Sonia Losada-Barreiro, Carlos Bravo-Díaz   +2 more
doaj   +1 more source