Results 41 to 50 of about 122,373 (292)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

The University Students’ Perceptions Using ChatGPT in Writing Skills

Lingua: Jurnal Bahasa, Sastra dan Pengajarannya
This study aimed to describe students' perceptions the use of ChatGPT in writing skills, as well as identify the advantages and disadvantages of using ChatGPT in writing skills. This study used a qualitative descriptive research design. The participants
Dwi Uswatun Hasanah, Muamaroh Muamaroh
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Comparative analysis of ChatGPT-4o mini, ChatGPT-4o and Gemini Advanced in the treatment of postmenopausal osteoporosis

BMC Musculoskeletal Disorders
Background Osteoporosis is a sex-specific disease. Postmenopausal osteoporosis (PMOP) has been the focus of public health research worldwide. The purpose of this study is to evaluate the quality and readability of artificial intelligence large-scale ...
Rui Liu, Jian Liu, Jia Yang, Zhiming Sun, Hua Yan   +4 more
doaj   +1 more source

Suicide Risk Assessments Through the Eyes of ChatGPT-3.5 Versus ChatGPT-4: Vignette Study

JMIR Mental Health, 2023
BackgroundChatGPT, a linguistic artificial intelligence (AI) model engineered by OpenAI, offers prospective contributions to mental health professionals.
Inbar Levkovich, Zohar Elyoseph
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

“ChatGPT seems too good to be true”: College students’ use and perceptions of generative AI

Computers and Education: Artificial Intelligence
This study investigates how U.S. college students (N = 1001) perceive and use ChatGPT, exploring its relationship with societal structures and student characteristics.
Clare Baek, Tamara Tate, Mark Warschauer
doaj   +1 more source

ChatGPT- Revolutionizing Higher-Ed Andragogy: a Positive Disruptor?

, 2023
This research investigates the influence of artificial intelligence bots, such as ChatGPT, on higher education andragogy. The research team intends to examine how the use of ChatGPT might impact the design of courses that focus on developing ...
Aalaa Salman (18021913), Christopher Hill (2070634), Sweta Bharadwaj (18074987)   +2 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source