Results 41 to 50 of about 100,948 (293)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
ChatGPT-3.5 and ChatGPT-4 Performance in Testicular Cancer: A Comparative Study [PDF]
Objective: The aim of our study is to assess the reliability of Chat Generative Pre-trained Transformer (ChatGPT), compare the performance of ChatGPT-4 to ChatGPT-3.5, and explore its potential roles in healthcare decision-making. Materials and Methods:
Süleyman Sağır +2 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Ethics and Information TechnologyAbstractRecently, there has been considerable interest in large language models: machine learning systems which produce human-like text and dialogue. Applications of these systems have been plagued by persistent inaccuracies in their output; these are often called “AI hallucinations”.
Michael Townsen Hicks +2 more
openaire +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
ChatGPT for computational topology
Foundations of Data ScienceChatGPT represents a significant milestone in the field of artificial intelligence (AI), finding widespread applications across diverse domains. However, its effectiveness in mathematical contexts has been somewhat constrained by its susceptibility to conceptual errors.
Jian Liu, Li Shen, Guo-Wei Wei 0001
openaire +4 more sources
ChatGPT, a sophisticated chatbot system by OpenAI, gained significant attention and adoption in 2022 and 2023. By generating human-like conversations, it attracted over 100 million monthly users; however, there are concerns about the social impact of ...
Clos, Jeremie +3 more
core +1 more source
Designing authentic assessments to address the use of chatGPT in higher education
, 2023 Since its official launch, there has been much discussion in academic circles around the use of artificial intelligence, specifically natural language processing models such as ChatGPT, with many seeming to focus on the distrust issues of student ...
ChatGPT +2 more
core
, 2023 A growing literature studies how humans incorporate advice from algorithms. This study examines an algorithm with millions of daily users: ChatGPT. We conduct a lab experiment in which 118 student participants answer 2,828 multiple-choice questions ...
Peter Zhang
core +1 more source