Results 51 to 60 of about 56,850 (248)

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Is It Getting Better? An Evaluation of Two Successive Generations of ChatGPT in Answering Specialized Vascular Surgery Questions

Vascular Specialist International
Purpose: Large language models (LLMs) can generate clinically relevant text; however, their performance in highly specialized medical domains remains uncertain.
Dongjin Suh, Quang Le, Leana Dogbe, Kedar Lavingia, Michael Amendola   +4 more
doaj   +1 more source

The language of ChatGPT [PDF]

 Miscin, E. (2024). The Language of ChatGPT. In D. K.-G. Chan et al. (Eds.), Evolving trends in foreign language education: Past lessons, present reflections, future directions. Proceedings from the 10th CLaSIC 2024 (pp. 249–258). Centre for Language Studies, Faculty of Arts and Social Sciences, National University of Singapore. https://doi.org/10.5281/
openaire   +2 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Factors affecting ChatGPT use in education employing TAM: A Jordanian universities’ perspective [PDF]

International Journal of Data and Network Science
The widespread adoption of artificial intelligence (AI) technologies, including ChatGPT, into education, has become a focal point of attention in recent years.
Muhammad Alshurideh, Asma Jdaitawi, Lilana Sukkari, Anwar Al-Gasaymeh, Haitham M. Alzoubi, Yousef Damra, Sara Yasin, Barween Al Kurdi , Hevron Alshurideh   +8 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

ChatGPT-3,5 and ChatGPT-4o performance in Specialty Certificate Examination in Diabetology: a comparative study.

Clinical Diabetology
OBJECTIVE: ChatGPT is an AI-powered chatbot that nowadays is becoming a valuable tool in various medical fields. In this study, we compare the effectiveness of ChatGPT-3.5 and ChatGPT-4o in completing the Specialty Certificate Examination in Diabetology.
Katarzyna Kler, Anna Kler, Aleksandra Wojno, Anna Karwowska, Justyna Putek, Edwin Kuźnik   +5 more
doaj   +1 more source

To ChatGPT, or not to ChatGPT: Navigating the paradoxes of generative AI in the advertising industry

Business Horizons
Generative AI (GenAI) technology is evoking both excitement and fear about its potential impact across a host of industries—including advertising, where it is expected to have a significant disruptive effect. This article utilizes the paradox lens to explore the implications of text-to-text GenAI in the form of ChatGPT for the advertising industry ...
Osadchaya, Elena, Marder, Ben, Yule, Jennifer A., Yau, Amy, Lavertu, Laura, Stylos, Nikolaos, Oliver, Sebastian, Angell, Rob, Regt, Anouk de, Gao, Liyu, Qi, Kang, Zhang, Will Zhiyuan, Zhang, Yiwei, Li, Jiayuan, AlRabiah, Sara   +14 more
openaire   +5 more sources