Results 111 to 120 of about 17,905 (274)
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Inflation, Central Bank Independence and the Legal System. [PDF]
We argue that a higher degree of de facto independence of the legal system from the other government branches as well as public trust in the legal system may reduce the average inflation record of countries through a direct and an indirect channel.
Bernd Hayo, Stefan Voigt
core
Studying the Position of the Public in Checks and Balances System [PDF]
مطالعات مدیریت بهبود و تحول, 2011 Power balance and control is considered as one of the most fundamental issues in the governance literature in which, position of the public as main owners of power is of paramount importance; however, it seems it is losing its importance more and more ...
Afifeh Hajjarian +3 more
doaj
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
THE SYSTEM OF CHECKS AND BALANCES IN THE REPUBLIC OF SOUTH AFRICA
The system of checks and balances in the Republic of South Africa is based on the principles of the separation of powers enshrined in the Constitution of 1996.
Alina Voichuk
core +1 more source
Studia Politicæ, 2013 Los Estados usualmente difieren de manera importante en cuanto a la provisión de bienes públicos y corrupción. ¿Por qué algunos gobiernos estatales son capaces de proveer adecuados servicios de salud y educación pero otros tienden a especializarse en la
Lee Alston +3 more
doaj
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Discretional political budget cycles and separation of powers [PDF]
In contrast to previous empirical work on electoral cycles, which implicitly assumes the executive has full discretion over fiscal policy, this paper contends that under separation of powers an unaligned legislature may have a moderating role.
Daniel Lema +2 more
core
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source