Results 91 to 100 of about 188,458 (274)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Strong Presidents, Robust Democracies? Separation of Powers and Rule of Law in Latin America
Brazilian Political Science Review, 2009 The received wisdom on Latin America in the 1980s and 1990s was that countries where presidents enjoyed strong constitutional powers and where multiparty coalitions prevailed would be doomed to instability and institutional crises, while countries ...
Marcus Melo
doaj
Role of the Court in the System of Checks and Balances
Теорія і практика правознавства, 2016 Analyzing current legislation on judiciary and its practical realization the author presents problems of mutual relations of courts with Verkhovna Rada of Ukraine, distinguishes the forms of their co-operation.
Ю. О. Рємєскова
doaj +1 more source
Separation of Powers and Political Budget Cycles [PDF]
From a theoretical viewpoint, political budget cycles (PBC) arise in equilibrium when rational voters are imperfectly informed about the incumbent's competency and the incumbent enjoys discretionary power over the budget. This paper focuses on the second
Alejandro Saporiti, Jorge M. Streb
core
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Правоприменение, 2018 The subject. The paper is devoted to legal analysis of category “checks and balances” in the scope of constitutional legal coercion.The purpose of the paper is to confirm or disprove hypothesis that mechanism of checks and balances is a method of ...
I. Tretyak
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Khazanah Hukum, 2021 Masalah Dalam penelitian ini menggunakan peneliatian normative dengan pendekatan kualitatif. penelitian ini bertujuan untuk memahami bagaimana desain model pengawasan hakim Mahkamah Konstitusi pasca putusan Mahkamah Konstitusi Nomor No.
Elfid Nurfitra Mubarok, Alwi Al Hadad
doaj
RELEVANSI HAK ANGKET TERHADAP KOMISI NEGARA INDEPENDEN
Dialogia Iuridica, 2018 Penelitian ini mengkaji dua hal. Pertama, prinsip checks and balances komisi negara independen. Kedua, relevansi hak angket dengan komisi negara independen. Penelitian ini merupakan normative legal research, dengan pendekatan historis, konseptual, kasus,
Idul Rishan
doaj +1 more source