Results 71 to 80 of about 17,905 (274)
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Проблеми Законності, 2015 The hypothesis of formation of the post-soviet authoritarianism nominated by foreign scholars has been considered. The features of the regulation of certain elements of the model of checks and balances in the constitution of the former Soviet Union have ...
К. О. Закоморна
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
COVID-19 e as reações ao federalismo bolsonarista
RP3. Revista de Pesquisa em Políticas Públicas, 2023 Assim como em muitos lugares do mundo, a COVID-19 provocou alterações nas relações entre os entes federados no Brasil; porém, aqui, tais transformações não tornaram o Estado mais capaz de responder às demandas de enfrentamento da pandemia. Sob o tema das
José Del Ben Neto +1 more
doaj +2 more sources
Checks and balances: an assessment of the institutional separation of political powers in Colombia
, 2000 In this paper, we evaluate the institutional and legal structure of the Colombian government. In particular, we want to assess how a system of institutional checks and balances can be structured to promote the rule of law, preserve property rights, and ...
Kugler, Maurice, Rosenthal, Howard
core +1 more source
Checks and Balances in the Criminal Law [PDF]
, 2021 The separation of powers is considered essential in the criminal law, where liberty and even life are at stake. Yet the reasons for separating criminal powers are surprisingly opaque, and “the separation of powers” is often used to refer to distinct, and
Epps, Daniel
core +2 more sources
Lame-Duck Legislation and Executive Aggrandisement in Indonesia
Arena HukumThis study examines legislative dynamics during presidential and parliamentary transition periods (lame-duck sessions) in Indonesia to address two questions: (1) how do political configurations shape the enactment of the Government Regulation in Lieu of
Muhammad Nazri +2 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Quantifying the checks and balances of collaborative governance systems for adaptive carnivore management. [PDF]
J Appl Ecol, 2022 Cusack JJ +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source