Results 71 to 80 of about 188,458 (274)
Проблеми Законності, 2015 The hypothesis of formation of the post-soviet authoritarianism nominated by foreign scholars has been considered. The features of the regulation of certain elements of the model of checks and balances in the constitution of the former Soviet Union have ...
К. О. Закоморна
doaj +1 more source
Localism may actually reduce citizen voice because information on citizen redress is either not collected or ignored [PDF]
, 2012 Citizen redress is essential for any government committed to administering accountable and efficient public sector services. However, as Jane Tinkler argues, the introduction of more complex provider networks in the Big Society threatens the already ...
Tinkler, Jane
core
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Strengthening of Institutional MPR in the Constitutional System of the Republic of Indonesia
Hasanuddin Law Review, 2015 The 1945 amendment were made in the sessions of the Assembly 1999-2000 has revolutionized state system of Indonesia, including concerning the status and function of state institutions. People’s Consultative Assembly (MPR) as one of the state institutions
Galang Asmara
doaj
, 2013 This essay reviews Power and Constraint: The Accountable Presidency After 9/11 by Jack Goldsmith (2012). With The Terror Presidency, Professor Jack Goldsmith wrote, hands down, the very best analysis of the national security issues surrounding President ...
Katyal, Neal K.
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Determinants of Presidential Veto in Semi-presidential System: Empirical Insights from Poland
EkonomistaThe primary objective of this paper is to investigate the determinants influencing the use of presidential vetoes in Poland, with a particular focus on the role of the anti-pluralist attitude of government and intra-executive identity differences, i.e ...
Anna Lewczuk
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
'Constitución mixta' en la república de Florencia a principios del siglo XVI
Gerión, 2019 En la tradición occidental ha predominado una única interpretación de la constitución mixta, la que aplicó Polibio a Esparta y a Roma. Sin embargo, en el pensamiento político griego existieron versiones anteriores y menos rígidas de esa idea de mezclar ...
Laura Sancho Rocher
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