Results 71 to 80 of about 13,565 (267)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

When do special interests run rampant ? disentangling the role in banking crises of elections, incomplete information, and checks and balances [PDF]

The author investigates the political determinants of government decisions that benefit special interest groups - especially government decisions to deal with banking crises. He finds that the better informed the voters, the more proximate elections, and
Keefer, Philip
core  

Determinants of Presidential Veto in Semi-presidential System: Empirical Insights from Poland

Ekonomista
The primary objective of this paper is to investigate the determinants influencing the use of presidential vetoes in Poland, with a particular focus on the role of the anti-pluralist attitude of government and intra-executive identity differences, i.e ...
Anna Lewczuk
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

'Constitución mixta' en la república de Florencia a principios del siglo XVI

Gerión, 2019
En la tradición occidental ha predominado una única interpretación de la constitución mixta, la que aplicó Polibio a Esparta y a Roma. Sin embargo, en el pensamiento político griego existieron versiones anteriores y menos rígidas de esa idea de mezclar ...
Laura Sancho Rocher
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Why Do Voters Dismantle Checks and Balances?

, 2020
Voters often dismantle constitutional checks and balances on the executive. If such checks and balances limit presidential abuses of power and rents, why do voters support their removal?
Daron Acemoglu, Ragnar Torvik, James A Robinson   +2 more
core  

COVID-19 e as reações ao federalismo bolsonarista

RP3. Revista de Pesquisa em Políticas Públicas, 2023
Assim como em muitos lugares do mundo, a COVID-19 provocou alterações nas relações entre os entes federados no Brasil; porém, aqui, tais transformações não tornaram o Estado mais capaz de responder às demandas de enfrentamento da pandemia. Sob o tema das
José Del Ben Neto, Graziela Donário de Azevedo   +1 more
doaj   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Quantifying the checks and balances of collaborative governance systems for adaptive carnivore management. [PDF]

J Appl Ecol, 2022
Cusack JJ, Nilsen EB, Israelsen MF, Andrén H, Grainger M, Linnell JDC, Odden J, Bunnefeld N.   +7 more
europepmc   +1 more source