Results 51 to 60 of about 8,217 (231)

COVID-19 e as reações ao federalismo bolsonarista

RP3. Revista de Pesquisa em Políticas Públicas, 2023
Assim como em muitos lugares do mundo, a COVID-19 provocou alterações nas relações entre os entes federados no Brasil; porém, aqui, tais transformações não tornaram o Estado mais capaz de responder às demandas de enfrentamento da pandemia. Sob o tema das
José Del Ben Neto, Graziela Donário de Azevedo   +1 more
doaj   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Determinants of Presidential Veto in Semi-presidential System: Empirical Insights from Poland

Ekonomista
The primary objective of this paper is to investigate the determinants influencing the use of presidential vetoes in Poland, with a particular focus on the role of the anti-pluralist attitude of government and intra-executive identity differences, i.e ...
Anna Lewczuk
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Strengthening of Institutional MPR in the Constitutional System of the Republic of Indonesia

Hasanuddin Law Review, 2015
The 1945 amendment were made in the sessions of the Assembly 1999-2000 has revolutionized state system of Indonesia, including concerning the status and function of state institutions. People’s Consultative Assembly (MPR) as one of the state institutions
Galang Asmara
doaj  

'Constitución mixta' en la república de Florencia a principios del siglo XVI

Gerión, 2019
En la tradición occidental ha predominado una única interpretación de la constitución mixta, la que aplicó Polibio a Esparta y a Roma. Sin embargo, en el pensamiento político griego existieron versiones anteriores y menos rígidas de esa idea de mezclar ...
Laura Sancho Rocher
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Pengaruh Pembatasan Kekuasaan Presiden Terhadap Praktik Ketatanegaraan Indonesia

Jurnal Konstitusi, 2016
This research effort to search the contents president power restriction in achieving constitutional governmant in Indonesia. The restriction power of president related to restriction of president authority.
Chrisdianto Eko Purnomo
doaj   +1 more source