Results 51 to 60 of about 188,458 (274)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

PRINSIP CHECKS AND BALANCES DITINJAU DARI SISI DAN PRAKTIK

Jurnal Hukum Volkgeist, 2019
The purpose of this research is to get a full description about the parliament concept in Indonesia that no clear enough use Threecameralism system (MPR, DPR, DPD) Bicameralism (DPR and DPD), or Unycameralism (MPR).
FAHARUDIN FAHARUDIN
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A Balance Check

JAACAP Connect, 2018
With both its challenges and its celebrations, 2018 continues to fly by, and in its jet stream, I frequently have had to do balance checks. For me—particularly in the context of the illness that has befallen a close family member—“work-life balance” has been challenging.
openaire   +1 more source

General covariance of the non-abelian DBI-action: Checks and Balances

, 2003
We perform three tests on our proposal to implement diffeomorphism invariance in the non-abelian D0-brane DBI action as a basepoint independence constraint between matrix Riemann normal coordinate systems.
Abbott, Abbott, Alvarez-Gaume, Bergshoeff, Bergshoeff, Cederwall, Cederwall, De Boer, Douglas, Friedan, Jan de Boer, Jeroen Wijnhout, Koenraad Schalm, Mukhi, Myers, Nagaoka, Sevrin, Taylor, Tseytlin, Van Raamsdonk   +19 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

IMPLIKASI PUTUSAN MAHKAHAM KONSTITUSI SEBAGAI POSITIF LEGISLATOR TERHADAP PRINSIP CHECK AND BALANCE

Jurnal Litigasi
Penelitian ini mengkaji implikasi putusan Mahkamah Konstitusi yang bersifat positif legislator terhadap prinsip checks and balances dalam sistem ketatanegaraan Indonesia.
Dewi Sulastri, Abu Sanmas
doaj   +1 more source

Checks and Balances: Measuring Checking Accounts' Safety and Transparency [PDF]

, 2013
Consumers need safe and transparent checking accounts. "Access to mainstream financial services at an insured institution," notes the Federal Deposit Insurance Corp., "provides consumers with a safe place to save, conduct basic financial transactions ...

core