Results 41 to 50 of about 8,217 (231)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Penguatan Pengelolaan Keuangan Negara Melalui Mekanisme Checks and Balances System

open access: yesJurnal Konstitusi, 2018
Tulisan ini memfokuskan pada 2 (dua) isu utama, yaitu: pertama, bagaimana membangun mekanisme sistem checks and balances dalam mengelola keuangan negara, agar sejalan dengan upaya mewujudkan transparansi dan akuntabilitas pengelolaan keuangan negara ...
Hendar Ristriawan, Dewi Kania Sugiharti
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Pemilihan Presiden Dan Penciptaan Mekanisme 'Checks and Balances': Menuju Penciptaan Sistem Presidensial Murni

open access: yesJSP: Jurnal Ilmu Sosial dan Ilmu Politik, 2002
The attempt to question the legitimacy of President Abdurrahman Wahid has led to reemergence of the idea of having a direct election for the filling the President post, instead of having an indirect election, namely through the People's Consultative ...
Afan Gaffar
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Constitucionalismo e Checks and Balances: Teoria e Pesquisa Empírica

open access: yesPrim@ Facie, 2012
Este artigo tem por objetivo apresentar e discutir as principais pesquisas empíricas sobre Constitucionalismo e Checks and Balances. O artigo está dividido da seguinte forma: a primeira parte versará sobre a trajetória do conceito de constitucionalismo ...
Saulo Felipe Costa   +2 more
doaj   +4 more sources

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

About some features of the post-soviet model of checks and balances in the context of the "managed democracy" regime: constitutional and legal aspect

open access: yesПроблеми Законності, 2015
The hypothesis of formation of the post-soviet authoritarianism nominated by foreign scholars has been considered. The features of the regulation of certain elements of the model of checks and balances in the constitution of the former Soviet Union have ...
К. О. Закоморна
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

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