Results 1 to 10 of about 10,320 (199)

CHEK1 is a synthetic lethal interactor of FBXO7 in colonic epithelial cells [PDF]

Molecular Therapy: Oncology
Colorectal cancer (CRC) remains a leading cause of cancer mortality worldwide, with chromosome instability (CIN) present in approximately 85% of cases and associated with poor prognosis.
Tooba Razi, Ally C. Farrell, Rubi Campos Gudiño, Nicole M. Neudorf, Zelda Lichtensztejn, Kirk J. McManus   +5 more
doaj   +5 more sources

CHEK1 and circCHEK1_246aa evoke chromosomal instability and induce bone lesion formation in multiple myeloma [PDF]

Molecular Cancer, 2021
Background Multiple myeloma (MM) is still incurable and characterized by clonal expansion of plasma cells in the bone marrow (BM). Therefore, effective therapeutic interventions must target both myeloma cells and the BM niche. Methods Cell proliferation,
Chunyan Gu, Mengjie Guo, Rongfang Wei
exaly   +8 more sources

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes [PDF]

Molecular Oncology
The luminal subtype (estrogen receptor‐positive, ER+) is the most common and the most heterogeneous type of breast carcinoma (BC) in women. During our study, we determined expression levels of all microRNAs (miRNome) in 101 ER+ BC samples and identified ...
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
doaj   +4 more sources

CHEK1 variant is a risk factor for premature ovarian insufficiency by mis- regulating metabolism and inflammation-related genes [PDF]

Human Genomics
Background Premature ovarian insufficiency (POI) is affecting approximately 1% of females and increasingly contributing to female infertility. The etiology of POI is heterogeneous.
Jianying Guo, Yali Fan, Zifan Song, Lin Li, Meng Fu   +4 more
doaj   +5 more sources

The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation [PDF]

Nature Communications, 2021
Atr is a serine/threonine kinase, known to sense single-stranded DNA breaks and activate the DNA damage checkpoint by phosphorylating Chek1, which inhibits Cdc25, causing cell cycle arrest. This pathway has not been implicated in neuroregeneration.
Leann Miles, Qin Wang, Harun Najib Noristani   +2 more
exaly   +6 more sources

Multi-omics analysis and functional validation of CHEK1 as an independent prognostic biomarker in Pancreatic cancer. [PDF]

PLoS ONE
BackgroundPancreatic cancer is a highly aggressive tumor with a poor prognosis due to challenging early diagnosis and limited treatment options. CHEK1, a crucial cell cycle regulator, is important in tumor development, but its role in pancreatic cancer ...
Xiaonan Wei, Ruirong Yan, Shanshan Wang, Yaru Jiang, Haibin Li, Yanping Li   +5 more
doaj   +4 more sources

Integrative bioinformatics analysis and experimental validation identify CHEK1 as an unfavorable prognostic biomarker related to immunosuppressive phenotypes in soft tissue sarcomas [PDF]

npj Precision Oncology
Soft tissue sarcomas (STS), including rhabdomyosarcoma (RMS), exhibit significant heterogeneity and limited responsiveness to immune checkpoint blockade (ICB).
Chao Rong, Yun Liu, Fang Xiang, Xin Zhao, Jinjin Zhang, Zuorun Xiao, Jinsha Wang, Lin Chen, Zhiqi Guo, Ziyu Zhang, Jingnan An, Jing Shen, Jochen Hess, Xiaodong Yuan, Qiong Zhang, Shouli Wang   +15 more
doaj   +4 more sources

Targeting CHEK1: Ginsenosides-Rh2 and Cu2O@G-Rh2 nanoparticles in thyroid cancer. [PDF]

Cell Biol Toxicol
Thyroid cancer (THCA) is an increasingly common malignant tumor of the endocrine system, with its incidence rising steadily in recent years. For patients who experience recurrence or metastasis, treatment options are relatively limited, and the prognosis
Wang L, Wu X, Wang X, Dong M, Zhang H, Zhao P.   +5 more
europepmc   +6 more sources

Predicting breast cancer prognosis based on a novel pathomics model through CHEK1 expression analysis using machine learning algorithms. [PDF]

PLoS One
Background Checkpoint kinase 1 (CHEK1) is often overexpressed in solid tumors. Nonetheless, the prognostic significance of CHEK1 in breast cancer (BrC) remains unclear.
Chen C, Gao D, Yue H, Wang H, Qu R, Hu X, Luo L.   +6 more
europepmc   +3 more sources

MiR-424-5p suppresses tumor growth and progression by directly targeting CHEK1 and activating cell cycle pathway in Hepatocellular Carcinoma

Heliyon
Objectives: The aim of this study is to elucidate the functional mechanism of the miRNA-424-5p/CHEK1 pathway in hepatocellular carcinoma (HCC), thereby offering novel insights for the development of targeted therapeutic strategies for HCC.
Chunlin Yin, Yuansong Sun, He Li, Xianxian Zheng   +3 more
doaj   +3 more sources