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TOP2A inhibition and its cellular effects related to cell cycle checkpoint adaptation pathway [PDF]
Scientific ReportsIn this study, we investigate the G2 checkpoint activated by chromosome entanglements, the so-called Decatenation Checkpoint (DC), which can be activated by TOP2A catalytic inhibition.
Maria Arroyo +5 more
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Can eukaryotic cells monitor the presence of unreplicated DNA? [PDF]
Cell Division, 2007 Completion of DNA replication before mitosis is essential for genome stability and cell viability. Cellular controls called checkpoints act as surveillance mechanisms capable of detecting errors and blocking cell cycle progression to allow time for those
Aragón Luis +2 more
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Cell Cycle Checkpoint Kinase and Drug Resistance of Lung Cancer [PDF]
Chinese Journal of Lung Cancer, 2021 Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer death. Although great progress has been made in chemotherapy, radiotherapy and targeted therapy, the emergence of acquired drug resistance hinders the efficacy of clinical ...
Zhiyin KE, Ailing LIANG, Yongjun LIU
doaj +2 more sources
The cell cycle checkpoint inhibitors in the treatment of leukemias [PDF]
Journal of Hematology & Oncology, 2017 The inhibition of the DNA damage response (DDR) pathway in the treatment of cancers has recently reached an exciting stage with several cell cycle checkpoint inhibitors that are now being tested in several clinical trials in cancer patients. Although the
A. Ghelli Luserna di Rora’ +2 more
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DNA damage checkpoint execution and the rules of its disengagement
Frontiers in Cell and Developmental Biology, 2022 Chromosomes are susceptible to damage during their duplication and segregation or when exposed to genotoxic stresses. Left uncorrected, these lesions can result in genomic instability, leading to cells’ diminished fitness, unbridled proliferation or ...
Candice Qiu Xia Yam +4 more
doaj +1 more source
The ATM-E6AP-MASTL axis mediates DNA damage checkpoint recovery
eLife, 2023 Checkpoint activation after DNA damage causes a transient cell cycle arrest by suppressing cyclin-dependent kinases (CDKs). However, it remains largely elusive how cell cycle recovery is initiated after DNA damage.
Yanqiu Li +6 more
doaj +1 more source
Checkpoint inhibition of origin firing prevents inappropriate replication outside of S-phase
eLife, 2021 Checkpoints maintain the order of cell cycle events during DNA damage or incomplete replication. How the checkpoint response is tailored to different phases of the cell cycle remains poorly understood.
Mark C Johnson +4 more
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Oncogenesis, 2021 Defective DNA repair is being demonstrated to be a useful target in cancer treatment. Currently, defective repair is identified by specific gene mutations, however defective repair is a common feature of cancers without these mutations.
Madushan Fernando +8 more
doaj +1 more source
npj Systems Biology and Applications, 2021 Different cancer cell lines can have varying responses to the same perturbations or stressful conditions. Cancer cells that have DNA damage checkpoint-related mutations are often more sensitive to gene perturbations including altered Plk1 and p53 ...
Yongwoon Jung +4 more
doaj +1 more source
Nature Communications, 2023 Ribosome biogenesis is a multi-step process, in which a network of trans-acting factors ensures the coordinated assembly of pre-ribosomal particles in order to generate functional ribosomes.
Judith Dönig +14 more
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