Results 41 to 50 of about 235,920 (306)

Cell Cycle Regulation by Checkpoints [PDF]

, 2014
Cell cycle checkpoints are surveillance mechanisms that monitor the order, integrity, and fidelity of the major events of the cell cycle. These include growth to the appropriate cell size, the replication and integrity of the chromosomes, and their accurate segregation at mitosis. Many of these mechanisms are ancient in origin and highly conserved, and
Kevin J, Barnum, Matthew J, O'Connell
openaire   +2 more sources

The Arabidopsis thaliana checkpoint kinase WEE1 protects against premature vascular differentiation during replication stress [PDF]

, 2011
A sessile lifestyle forces plants to respond promptly to factors that affect their genomic integrity. Therefore, plants have developed checkpoint mechanisms to arrest cell cycle progression upon the occurrence of DNA stress, allowing the DNA to be ...
Cools, Toon, Iantcheva, Anelia, Weimer, Annika K, Boens, Shannah, Takahashi, Naoki, Maes, Sara, Van Den Daele, Hilde, Van Isterdael, Gert, Schnittger, Arp, De Veylder, Lieven   +9 more
core   +2 more sources

WEE1 kinase inhibition reverses G2/M cell cycle checkpoint activation to sensitize cancer cells to immunotherapy

OncoImmunology, 2018
Intrinsic resistance to cytotoxic T-lymphocyte (CTL) killing limits responses to immune activating anti-cancer therapies. Here, we established that activation of the G2/M cell cycle checkpoint results in tumor cell cycle pause and protection from ...
Lillian Sun, Ellen Moore, Rose Berman, Paul E. Clavijo, Anthony Saleh, Zhong Chen, Carter Van Waes, John Davies, Jay Friedman, Clint T. Allen   +9 more
doaj   +1 more source

Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failure

BMC Cell Biology, 2005
Background Mammalian cells have been reported to have a p53-dependent tetraploidy checkpoint that blocks cell cycle progression in G1 in response to failure of cell division.
Stearns Tim, Wong Connie
doaj   +1 more source

Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition. [PDF]

, 2010
The protein kinase Aurora-A is a major regulator of the cell cycle that orchestrates mitotic entry and is required for the assembly of a functional mitotic spindle.
Afshan McCarthy, Alan Ashworth, Chan Tang, Christopher J. Lord, Despina Maniotis, Giet R, Goggins M, Gritsko TM, Spiros Linardopoulos, Tony Sourisseau   +9 more
core   +2 more sources

Phosphorylation of the MBF repressor Yox1p by the DNA replication checkpoint keeps the G1/S cell-cycle transcriptional program active.

PLoS ONE, 2011
BackgroundIn fission yeast Schizosaccharomyces pombe G1/S cell-cycle regulated transcription depends upon MBF. A negative feedback loop involving Nrm1p and Yox1p bound to MBF leads to transcriptional repression as cells exit G1 phase. However, activation
Catia Caetano, Steffi Klier, Robertus A M de Bruin   +2 more
doaj   +1 more source

Cell cycle checkpoint control [PDF]

Experimental & Molecular Medicine, 1997
Genetic instability is considered to be a major driving force of malignancy of cancer cells, and at least some of cancer-associated genetic instability is known to be caused by defects in the cell cycle checkpoint control. Patients of the cancer-prone genetic disorder ataxia telangiectagia frequently develop malignant lymphoma and their cells are ...
Hiroshi Murakami, Hiroto Okayama
openaire   +1 more source

The G2 checkpoint activated by DNA damage does not prevent genome instability in plant cells [PDF]

, 2006
Root growth, G2 length, and the frequency of aberrant mitoses and apoptotic nuclei were recorded after a single X-ray irradiation, ranging from 2.5 to 40 Gy, in Allium cepa L. root meristematic cells.
Carballo, Jesús A, de la Torre, Consuelo, Pincheira, Juana   +2 more
core   +4 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

DNA resection in eukaryotes: deciding how to fix the break [PDF]

, 2010
DNA double-strand breaks are repaired by different mechanisms, including homologous recombination and nonhomologous end-joining. DNA-end resection, the first step in recombination, is a key step that contributes to the choice of DSB repair.
A Aguilera, A Jazayeri, A Jazayeri, A Penkner, AA Sartori, AH McKee, AV Nimonkar, B Gu, BB Hopkins, BM Lengsfeld, BO Krogh, C Uanschou, C Zierhut, CF Cheok, CJ Lord, D Mantiero, D Nakada, DA Bressan, DO Warmerdam, E Baroni, EP Mimitou, F Lazzaro, G Chinnadurai, G Ira, G Wu, I Morin, J Buis, J Falck, JC Harrison, JH Barlow, JH Kim, JP Duxin, K Lee, K Shimada, KM Trujillo, L Chen, L Chen, L Maringele, L Zheng, M Clerici, M Clerici, M Grenon, M Lisby, M McVey, MF Lavin, MH Yun, MJ Neale, MR Lieber, O Limbo, P Huertas, P Huertas, Pablo Huertas, PL Chen, PT Tran, R Linding, R Waltes, RR Khakhar, RS Williams, S Gravel, S Liao, S Moreau, S Prinz, SH Bae, SK Amundsen, T Usui, TH Stracker, TT Paull, WS Dynan, X Yu, X Yu, Y Akamatsu, Y Aylon, Y Zhang, Z Horejsí, Z Zhu   +74 more
core   +1 more source