Results 21 to 30 of about 235,920 (306)

The bacterial cell cycle checkpoint protein Obg and its role in programmed cell death

Microbial Cell, 2016
The phenomenon of programmed cell death (PCD), in which cells initiate their own demise, is not restricted to multicellular organisms. Unicellular organisms, both eukaryotes and prokaryotes, also possess pathways that mediate PCD.
Liselot Dewachter, Natalie Verstraeten, Maarten Fauvart, Jan Michiels   +3 more
doaj   +1 more source

Fanconi anemia cells with unrepaired DNA damage activate components of the checkpoint recovery process [PDF]

, 2015
International audienceBACKGROUND:The FA/BRCA pathway repairs DNA interstrand crosslinks. Mutations in this pathway cause Fanconi anemia (FA), a chromosome instability syndrome with bone marrow failure and cancer predisposition.
Azpeitia, Eugenio, Cortes, Edith, Frias, Sara, Garcia-de Teresa, Benilde, Juarez, Ulises, Mendoza, Luis, Ortiz, Rocio, Ostrosky-Wegman, Patricia, Rodriguez, Alfredo, Salazar, Ana M., Sosa, David, Torres, Leda   +11 more
core   +4 more sources

Combined Dusp4 and p53 loss with Dbf4 amplification drives tumorigenesis via cell cycle restriction and replication stress escape in breast cancer

Breast Cancer Research, 2022
Aim Deregulated signaling pathways are a hallmark feature of oncogenesis and driver of tumor progression. Dual specificity protein phosphatase 4 (DUSP4) is a critical negative regulator of the mitogen-activated protein kinase (MAPK) pathway and is often ...
Ann Hanna, Mellissa J. Nixon, M. Valeria Estrada, Violeta Sanchez, Quanhu Sheng, Susan R. Opalenik, Abigail L. Toren, Joshua Bauer, Phillip Owens, Frank M. Mason, Rebecca S. Cook, Melinda E. Sanders, Carlos L. Arteaga, Justin M. Balko   +13 more
doaj   +1 more source

Vaccinia Virus Arrests and Shifts the Cell Cycle

Viruses, 2022
Modulation of the host cell cycle is a common strategy used by viruses to create a pro-replicative environment. To facilitate viral genome replication, vaccinia virus (VACV) has been reported to alter cell cycle regulation and trigger the host cell DNA ...
Caroline K. Martin, Jerzy Samolej, Annabel T. Olson, Cosetta Bertoli, Matthew S. Wiebe, Robertus A. M. de Bruin, Jason Mercer   +6 more
doaj   +1 more source

Analysis of Checkpoint Responses to Histone Deacetylase Inhibitors [PDF]

, 2004
Cell cycle checkpoints respond to a wide range of stresses to prevent compromise to the integrity of the cell. The best studied checkpoints are those induced by genotoxic agents that cause DNA damage.
Beamish, Heather, Gabrielli, Brian G., Warrener, Robyn   +2 more
core   +1 more source

RAD6-RAD18-RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light [PDF]

, 2009
In nature, organisms are exposed to chronic low- dose ultraviolet light ( CLUV) as opposed to the acute high doses common to laboratory experiments. Analysis of the cellular response to acute high-dose exposure has delineated the importance of direct DNA
Carr, Antony M, Hishida, T, Iwasaki, H, Kubota, Y   +3 more
core   +1 more source

Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing [PDF]

, 2001
Checkpoints maintain order and fidelity in the cell cycle by blocking late-occurring events when earlier events are improperly executed. Here we describe evidence for the participation of Chk1 in an intra-S phase checkpoint in mammalian cells.
Feijoo, Carmen, Gilbert, David M., Hall-Jackson, Clare, Jenkins, David, Leitch, Jane, Smythe, Carl, Wu, Rong   +6 more
core   +2 more sources

Haspin Modulates the G2/M Transition Delay in Response to Polarization Failures in Budding Yeast

Frontiers in Cell and Developmental Biology, 2021
Symmetry breaking by cellular polarization is an exquisite requirement for the cell-cycle of Saccharomyces cerevisiae cells, as it allows bud emergence and growth.
Martina Galli, Laura Diani, Roberto Quadri, Alessandro Nespoli, Elena Galati, Davide Panigada, Paolo Plevani, Marco Muzi-Falconi   +7 more
doaj   +1 more source

Direct and indirect control of the initiation of meiotic recombination by DNA damage checkpoint mechanisms in budding yeast [PDF]

, 2013
Meiotic recombination plays an essential role in the proper segregation of chromosomes at meiosis I in many sexually reproducing organisms. Meiotic recombination is initiated by the scheduled formation of genome-wide DNA double-strand breaks (DSBs).
AJ MacQueen, AL Goldstein, BH Lee, Bilge Argunhan, C Buhler, CY Bonilla, E Martini, EF Joyce, G Vader, H Sasanuma, H Sun, H Toyoizumi, H Tsubouchi, H-C Ho, H-Y Wu, HG Blitzblau, Hideo Tsubouchi, Hiroshi Toyoizumi, J Lange, JC Harrison, JE Haber, JL Gerton, KA Henderson, KS Tung, L Wan, L Xu, L Zou, M Lichten, M Lisby, M Petronczki, Michael Lichten, MJ Neale, Neil Humphryes, S Chu, S Farmer, S Farmer, S Keeney, Sarah Farmer, Tomomi Tsubouchi, Wing-Kit Leung, Yaroslav Terentyev   +40 more
core   +3 more sources

Checkpoints are blind to replication restart and recombination intermediates that result in gross chromosomal rearrangements [PDF]

, 2015
Replication fork inactivation can be overcome by homologous recombination, but this can cause gross chromosomal rearrangements that subsequently missegregate at mitosis, driving further chromosome instability.
A Janssen, A Letessier, AT Watson, AT Watson, BJ Brewer, C Lukas, D Branzei, E Ampatzidou, E Tsang, EK Schwartz, HD Lindsay, I Miyabe, J Bartkova, J Matos, JA Harrigan, JM Murray, K Mizuno, K Mizuno, K Tanaka, KL Chan, KL Chan, LJ Gaskell, MN Boddy, NC Walworth, O Limbo, P Huertas, PM Dehe, RA Burrell, S Lambert, S Lambert, S Minocherhomji, S Sarbajna, S Ying, SC Ip, SG Durkin, SM Mirkin, T Caspari, V Naim, VG Gorgoulis, X Li   +39 more
core   +1 more source