Cell size checkpoint control by the retinoblastoma tumor suppressor pathway. [PDF]
PLoS Genetics, 2006 Size control is essential for all proliferating cells, and is thought to be regulated by checkpoints that couple cell size to cell cycle progression.
Su-Chiung Fang +2 more
doaj +1 more source
Acceleration or Brakes: Which Is Rational for Cell Cycle-Targeting Neuroblastoma Therapy?
Biomolecules, 2021 Unrestrained proliferation is a common feature of malignant neoplasms. Targeting the cell cycle is a therapeutic strategy to prevent unlimited cell division.
Kiyohiro Ando, Akira Nakagawara
doaj +1 more source
Direct monitoring of the strand passage reaction of DNA topoisomerase II triggers checkpoint activation. [PDF]
PLoS Genetics, 2013 By necessity, the ancient activity of type II topoisomerases co-evolved with the double-helical structure of DNA, at least in organisms with circular genomes.
Katherine L Furniss +7 more
doaj +1 more source
Elevated levels of the polo kinase Cdc5 override the Mec1/ATR checkpoint in budding yeast by acting at different steps of the signaling pathway. [PDF]
PLoS Genetics, 2010 Checkpoints are surveillance mechanisms that constitute a barrier to oncogenesis by preserving genome integrity. Loss of checkpoint function is an early event in tumorigenesis.
Roberto Antonio Donnianni +7 more
doaj +1 more source
DNA damage stress: Cui prodest? [PDF]
, 2019 DNA is an entity shielded by mechanisms that maintain genomic stability and are essential for living cells; however, DNA is constantly subject to assaults from the environment throughout the cellular life span, making the genome susceptible to mutation ...
Cialfi, Samantha +5 more
core +1 more source
Centrosome-associated regulators of the G2/M checkpoint as targets for cancer therapy
Molecular Cancer, 2009 In eukaryotic cells, control mechanisms have developed that restrain cell-cycle transitions in response to stress. These regulatory pathways are termed cell-cycle checkpoints.
Broaddus Russell R +5 more
doaj +1 more source
Novel functions of the phosphatase SHP2 in the DNA replication and damage checkpoints. [PDF]
PLoS ONE, 2012 Replication stress- and DNA damage-induced cell cycle checkpoints are critical for maintaining genome stability. To identify protein phosphatases involved in the activation and maintenance of the checkpoints, we have carried out RNA interference-based ...
Yiu Huen Tsang +4 more
doaj +1 more source
Signalling cell cycle arrest and cell death through the MMR System [PDF]
, 2006 Loss of DNA mismatch repair (MMR) in mammalian cells, as well as having a causative role in cancer, has been linked to resistance to certain DNA damaging agents including clinically important cytotoxic chemotherapeutics.
Brown, R., O'Brien, V.
core +1 more source
Pathways for Genome Integrity in G2 Phase of the Cell Cycle
Biomolecules, 2012 The maintenance of genome integrity is important for normal cellular functions, organism development and the prevention of diseases, such as cancer. Cellular pathways respond immediately to DNA breaks leading to the initiation of a multi-facetted DNA ...
Claus Storgaard Sørensen +2 more
doaj +1 more source
PLoS Biology, 2010 DNA damage checkpoints arrest cell cycle progression to facilitate DNA repair. The ability to survive genotoxic insults depends not only on the initiation of cell cycle checkpoints but also on checkpoint maintenance.
Marcel A T M van Vugt +15 more
doaj +1 more source