Results 31 to 40 of about 235,920 (306)

A Previously Unknown Unique Challenge for Inhibitors of SYK ATP-Binding Site: Role of SYK as A Cell Cycle Checkpoint Regulator

EBioMedicine, 2014
The identification of SYK as a molecular target in B-lineage leukemia/lymphoma cells prompted the development of SYK inhibitors as a new class of anti-cancer drug candidates.
Fatih M. Uckun, Hong Ma, Zahide Ozer, Patricia Goodman, Jian Zhang, Sanjive Qazi   +5 more
doaj   +1 more source

Phosphorylation-dependent assembly and coordination of the DNA damage checkpoint apparatus by Rad4TopBP1 [PDF]

, 2013
The BRCT-domain protein Rad4(TopBP1) facilitates activation of the DNA damage checkpoint in Schizosaccharomyces pombe by physically coupling the Rad9-Rad1-Hus1 clamp, the Rad3(ATR) -Rad26(ATRIP) kinase complex, and the Crb2(53BP1) mediator.
Alcasabas, Antony M. Carr, Antony W. Oliver, Boos, Cescutti, Christopher P. Wardlaw, Du, Du, Du, Esashi, Fenech, Fukuura, Furuya, Garcia, Gong, Jing-Yi Ren, Kilkenny, Kumagai, Kumagai, Kumagai, Laurence H. Pearl, Lee, Lee, Li-Lin Du, Lin, Mathieu Rappas, Matthew Day, Meng Qu, Qu, Rappas, Rothbauer, Saka, Shiozaki, Smits, Stucki, Takeishi, Tanaka, Taylor, Valerie Garcia, Williams, Willson   +40 more
core   +1 more source

CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptation. [PDF]

PLoS Biology, 2010
The Saccharomyces cerevisiae polo-like kinase Cdc5 promotes adaptation to the DNA damage checkpoint, in addition to its numerous roles in mitotic progression.
Genevieve M Vidanes, Frédéric D Sweeney, Sarah Galicia, Stephanie Cheung, John P Doyle, Daniel Durocher, David P Toczyski   +6 more
doaj   +1 more source

Possible attenuation of the G2 DNA damage cell cycle checkpoint in HeLa cells by extremely low frequency (ELF) electromagnetic fields [PDF]

, 2002
BACKGROUND: The issue remains unresolved as to whether low frequency magnetic fields can affect cell behaviour, with the possibility that they may be in part responsible for the increased incidence of leukaemia in parts of the population exposed to ...
Harris, Paul A., Heaton, Brian, Lamb, Justin, Wheatley, Denys N.   +3 more
core   +3 more sources

The extent of error-prone replication-restart by homologous recombination is controlled by Exo1 and checkpoint proteins [PDF]

, 2014
Genetic instability, a hallmark of cancer, can occur when the replication machinery encounters a barrier. The intra-S phase checkpoint maintains stalled replication forks in a replication-competent configuration by phosphorylating replisome components ...
Ahn, Alabert, Bailis, Barlow, Bastia, Bester, Biswas, Boddy, Bolderson, Brown, Bähler, Carr, Carr, Casper, Cha, Chen, Cobb, Cobb, Codlin, Cotta-Ramusino, Dalgaard, De Piccoli, Durkin, El-Shemerly, Errico, Eydmann, Froget, Haghnazari, Halazonetis, Hartsuiker, Heichinger, Hu, Iraqui, Jia, Kai, Kaochar, Katou, Kolodner, Koundrioukoff, Krejci, Lambert, Lambert, Lambert, Lambert, Lambert, Lambert, Lee, Lindsay, Lisby, Lopes, Lucca, Maundrell, Meister, Mimitou, Miyabe, Miyabe, Mizuno, Mizuno, Moreau, Moreau, Moreno, Morin, Myung, Myung, Pandita, Raynard, Sabatinos, Segurado, Segurado, Smolka, Sogo, Stracker, Sun, Symington, Sørensen, Tercero, Tsubouchi, Watson, Zhu, Zou, Zubko   +80 more
core   +2 more sources

Pulsatile MAPK Signaling Modulates p53 Activity to Control Cell Fate Decisions at the G2 Checkpoint for DNA Damage

Cell Reports, 2020
Summary: Cell-autonomous changes in p53 expression govern the duration and outcome of cell-cycle arrest at the G2 checkpoint for DNA damage. Here, we report that mitogen-activated protein kinase (MAPK) signaling integrates extracellular cues with p53 ...
Siddharth De, Callum Campbell, Ashok R. Venkitaraman, Alessandro Esposito   +3 more
doaj   +1 more source

Prediction Of Cancer Possibility By Pattern Recognition And Statistical Study Of Expression Of Gene Level Of Cancer Cells [PDF]

, 2011
The activity of the p53 tumor-suppressor protein has a key role in controlling both cancer and aging: under activity encourages the growth of cancer, and over activity can accelerate the aging process.
Devang Odedra, Medhavi Mallick
core   +2 more sources

The anaphase-promoting complex or cyclosome supports cell survival in response to endoplasmic reticulum stress. [PDF]

PLoS ONE, 2012
The anaphase-promoting complex or cyclosome (APC/C) is a multi-subunit ubiquitin ligase that regulates exit from mitosis and G1 phase of the cell cycle.
Meifan Chen, Gustavo J Gutierrez, Ze'ev A Ronai   +2 more
doaj   +1 more source

Targeting ATM pathway for therapeutic intervention in cancer [PDF]

, 2012
The Ataxia Telangiectasia Mutated gene encodes the ATM protein, a key element in the DNA damage response (DDR) signalling pathway responsible for maintaining genomic integrity within the cell.
Chakarov, Stoyan, Khalil, Hilal S., Lane, David P., Tummala, Hemanth, Zhelev, Nikolai   +4 more
core   +3 more sources

bir1 deletion causes malfunction of the spindle assembly checkpoint and apoptosis in yeast

Frontiers in Oncology, 2012
Cell division in yeast is a highly regulated and well studied event. Various checkpoints are placed throughout the cell cycle to ensure faithful segregation of sister chromatids.
Qun eRen, Liang-Chun eLiou, Qiuqiang eGao, Qiuqiang eGao, Xiaoming eBao, Zhaojie eZhang   +5 more
doaj   +1 more source