Results 91 to 100 of about 10,320 (199)

Elevated cortisol concentration in preterm sheep fetuses impacts heart development

Experimental Physiology, Volume 110, Issue 12, Page 1928-1947, December 1, 2025.
Abstract The prepartum rise in cortisol promotes cardiac development and maturation. Here, we investigated the impact of elevated circulating cortisol during mid‐late gestation on cardiac growth and metabolism in fetal sheep. Saline or cortisol (2–3 mg in 4.4 mL/24 h) was infused into the fetal jugular vein from 109 to 116 days gestation (dG, term ...
Reza Amanollahi, Stacey L. Holman, Melanie R. Bertossa, Ashley S. Meakin, Vicki L. Clifton, Kent L. Thornburg, I. Caroline McMillen, Michael D. Wiese, Mitchell C. Lock, Janna L. Morrison   +9 more
wiley   +1 more source

Relationship between chromosomal aberrations and gene expressions in the p53 pathway in chronic lymphocytic leukemia

Balkan Journal of Medical Genetics, 2020
Chronic lymphocytic leukemia (CLL) is a neoplasm characterized by excessive accumulation of B lymphocytes in the peripheral blood, bone marrow and lymph nodes.
Öztan G, Aktan M, Palanduz S, İşsever H, Öztürk S, Nikerel E, Uçur A, Bağatir G, Bayrak A, Çefle K   +9 more
doaj   +1 more source

Response to Carboplatin and Paclitaxel in the treatment of hereditary breast ovarian cancer syndrome (HBOC): a case report

Journal of the Pakistan Medical Association
The co-occurrence of primary breast cancer and primary ovarian cancer is an exceptional hereditary phenomenon and results from inherent mutations in critical genes like BRCA1/2, PALB2, TP53, CHEK1, and ATM.
Faisal Mehmood, Mumtaz Touseef, Amna Ashraf, Izza Ali Rai   +3 more
doaj   +1 more source

Investigating the Potential of Curcumin in the Treatment of Nonsmall Cell Lung Cancer: A Systematic Review With Meta‐Analysis, Network Pharmacology, and Mendelian Randomization

Phytotherapy Research, Volume 39, Issue 11, Page 5062-5084, November 2025.
ABSTRACT To evaluate the efficacy and explore the potential mechanism of curcumin for the treatment and prevention of NSCLC. We searched six databases thoroughly for articles published before December 2024. Stata 15.0 software was applied for systematic review with meta‐analysis.
Yonglu Guo, Haohao Xu, Peng Shen, Ruijun Cai   +3 more
wiley   +1 more source

Cholinergic Receptor Nicotinic Alpha 5 (CHRNA5) RNAi is associated with cell cycle inhibition, apoptosis, DNA damage response and drug sensitivity in breast cancer.

PLoS ONE, 2018
Cholinergic Receptor Nicotinic Alpha 5 (CHRNA5) is an important susceptibility locus for nicotine addiction and lung cancer. Depletion of CHRNA5 has been associated with reduced cell viability, increased apoptosis and alterations in cellular motility in ...
Sahika Cingir Koker, Ermira Jahja, Huma Shehwana, Ayse Gokce Keskus, Ozlen Konu   +4 more
doaj   +1 more source

Integrated Genomic and Transcriptomic Profiling of Isolated Trisomies in AML Reveals Cell Cycle Dysregulation and Therapeutic Vulnerabilities

Journal of Cellular and Molecular Medicine, Volume 29, Issue 22, November 2025.
ABSTRACT Acute myeloid leukaemia (AML) with isolated trisomies (ITs) represents a distinct cytogenetic subgroup with heterogeneous clinical behaviour and incompletely defined molecular features. To explore its genomic and transcriptomic landscape, we performed next‐generation sequencing (NGS) on 14 AML patients harbouring isolated trisomies of ...
Jersey Heitor da S. Maués, Bruno Kosa L. Duarte, Maria Carolina C. M. Svidnicki, Herton Luiz A. S. Filho, Fernanda Soares Niemann, Adriana da Silva S. Duarte, Paula de Melo Campos, Pedro M. Moraes‐Vieira, Sara Teresinha Olalla Saad   +8 more
wiley   +1 more source

Table S1 from Synthetic Lethality Interaction Between Aurora Kinases and CHEK1 Inhibitors in Ovarian Cancer

, 2023
<p>List of identified deregulated genes between non-transformed human epithelial ovarian cells and ovarian carcinoma cells.</p>
Alberto Ocaña, Atanasio Pandiella, Eva María Galán-Moya, Juan Llopis, Miguel Burgos, Juan Carlos Montero, Fernando Andrés-Pretel, Leticia Serrano-Oviedo, Verónica Corrales-Sánchez, Cristina Nieto-Jiménez, Ana Alcaraz-Sanabria   +10 more
openaire   +1 more source

Supplementary Methods and Materials from Thymoquinone Triggers Inactivation of the Stress Response Pathway Sensor <i>CHEK1</i> and Contributes to Apoptosis in Colorectal Cancer Cells

, 2023
Hala Gali‐Muhtasib, Doerthe Kuester, Christian Mawrin, Khuloud Bajbouj, Antje Diestel, Matthias Ocker, Caroline Habold, Charlotte Foltzer‐Jourdainne, Peter Schoenfeld, Brigitte Peters, Mona Diab‐Assaf, Ulf Pommrich, Wafica Itani, H. Lippert, Albert Roessner, Regine Schneider‐Stock   +15 more
openalex   +1 more source

Targeting cell cycle proteins in breast cancer cells with siRNA by using lipid-substituted polyethylenimines

Frontiers in Bioengineering and Biotechnology, 2015
The cell cycle proteins are key regulators of cell cycle progression whose de-regulation is one of the causes of breast cancer. RNA interference (RNAi) is an endogenous mechanism to regulate gene expression and it could serve as the basis of regulating ...
Manoj eParmar, Hamid M. Aliabadi, Parvin eMahdipoor, Cezary eKucharski, Robert eMaranchuk, Judith C Hugh, Hasan eUludag   +6 more
doaj   +1 more source

Supplementary from RNF126 as a Biomarker of a Poor Prognosis in Invasive Breast Cancer and CHEK1 Inhibitor Efficacy in Breast Cancer Cells

, 2023
Xiao‐Song Yang, Pan You, Zhaojun Qiu, Zhanwen Du, Yao Zhang, Pengyan Fa, Shashank Gorityala, Shanhuai Ma, Shunqiang Li, Ceshi Chen, Hongbing Wang, Yan Xu, Chunhong Yan, Keri Ruth, Zhefu Ma, Junran Zhang   +15 more
openalex   +1 more source