Results 171 to 180 of about 10,320 (199)
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CHEK1: a hub gene related to poor prognosis for lung adenocarcinoma.
Biomarkers in Medicine, 2021Aim: The study aims to pinpoint hub genes and investigate their functions in order to gain insightful understandings of lung adenocarcinoma (LUAD). Methods: Bioinformatic approaches were adopted to investigate genes in databases including Gene Expression
Z. Tan +8 more
semanticscholar +4 more sources
Critical Reviews in Eukaryotic Gene Expression, 2020
Multiple myeloma (MM) is one of the most common malignancies, and the clinical outcome of patients with MM remains poor. Our objective is to screen biomarkers correlated with clinicopathological features and survival of patients with MM.
Xiao-ping Liu +6 more
semanticscholar +3 more sources
Multiple myeloma (MM) is one of the most common malignancies, and the clinical outcome of patients with MM remains poor. Our objective is to screen biomarkers correlated with clinicopathological features and survival of patients with MM.
Xiao-ping Liu +6 more
semanticscholar +3 more sources
YY1‐mediated up‐regulation of lncRNA LINC00466 facilitates glioma progression via miR‐508/CHEK1
The Journal of Gene Medicine, 2020The abnormal expression of lncRNA LINC00466 (LINC00466) has been demonstrated in several tumor types. However, the expression pattern and functions of LINC00466 in glioma remain uninvestigated.
Qian-Kun Sha +3 more
semanticscholar +3 more sources
HOTAIR promotes paclitaxel resistance by regulating CHEK1 in ovarian cancer
Cancer Chemotherapy and Pharmacology, 2020The HOX transcript antisense RNA (HOTAIR) has been reported to be aberrantly expressed in ovarian cancer (OC). Abnormal high expression level of HOTAIR has been found to be associated with poor overall survival of OC patients. Yet, the role of HOTAIR in paclitaxel resistance of OC is unclear.
Jiahong Jiang +10 more
semanticscholar +3 more sources
FOXM1 Promotes Non-Small Cell Lung Cancer Progression by Increasing CHEK1 Expression
Current Medical ScienceXiao-Ning Lu +9 more
semanticscholar +2 more sources
MiR-139-3p Targets CHEK1 Modulating DNA Repair and Cell Viability in Lung Squamous Carcinoma Cells
Molecular Biotechnology, 2022Non-small-cell lung carcinoma (NSCLC) can be classified into several subtypes, where lung squamous carcinoma (LUSC) is one common subtype. Though miR-139-3p has been reported to be implicated in the development of various cancers, its mechanisms and functions remain unclear in LUSC.
Xiaoyu Zheng +4 more
semanticscholar +3 more sources
Development of 6-substituted indolylquinolinones as potent Chek1 kinase inhibitors
Bioorganic and Medicinal Chemistry Letters, 2006Through a comparison of X-ray co-crystallographic data for 1 and 2 in the Chek1 active site, it was hypothesized that the affinity of the indolylquinolinone series (2) for Chek1 kinase would be improved via C6 substitution into the hydrophobic region I (HI) pocket.
James Hardwick, Laura Sepp-Lorenzino
exaly +3 more sources
Endogenous Replication Stress Marks Melanomas Sensitive to CHEK1 Inhibitors In Vivo
Clinical Cancer Research, 2018Abstract Purpose: Checkpoint kinase 1 inhibitors (CHEK1i) have single-agent activity in vitro and in vivo. Here, we have investigated the molecular basis of this activity. Experimental Design: We have assessed a panel of melanoma cell lines for their sensitivity to the CHEK1i GNE-323 and GDC-0575 in vitro and in vivo.
Zay Yar Oo +12 more
openaire +3 more sources
[CHEK1 expression and inhibitors in TP53 mutant cancer].
Magyar onkologia, 2020The most frequently mutated gene in human tumors is TP53 and its mutation significantly deteriorates patients' survival. However, to date no targeted therapy is established for TP53 mutated tumors. Here, our aim was to identify druggable kinases with higher expression in TP53 mutated tumors, as well as relate these to altered prognosis.
Ágnes, Õsz +6 more
openaire +1 more source