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Abstract 5179: Context-specific dependence of ovarian cancer on IKKϵ and CHEK1

Cancer Research, 2014
Abstract Background: The IκB kinase, IKKϵ, was previously identified as an oncogene in breast cancer and was associated with poor clinical outcome in ovarian cancer. Recently, we demonstrated that IKKϵ is a key regulator of invasion and metastasis in ovarian cancer.
Marianne K. H. Kim +3 more
openaire +1 more source

Aberrant Splicing in CHEK1 Is a Driver of Megakaryocytic Dysplasia in U2AF1S34F Mutant Myelodysplastic Syndromes

Blood
Background: U2AF1 mutations are very common in MDS, indicating that aberrant splicing of pre-mRNA driven by mutant U2AF1 plays a critical role in MDS pathogenesis.
Wenjun Zhang +4 more
semanticscholar +1 more source

The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation

2020
ABSTRACTAtr is a serine/threonine kinase, known to sense single-stranded DNA breaks and activate the DNA damage checkpoint by phosphorylating Chek1, which inhibits Cdc25, causing cell cycle arrest. This pathway has not been implicated in neuroregeneration. We show that inDrosophilasensory neurons, removing Atr or Chek1, or overexpressing Cdc25 promotes
Feng Li +17 more
openaire +1 more source

CTPS1 is a novel therapeutic target in multiple myeloma which synergizes with inhibition of CHEK1, ATR or WEE1