Results 11 to 20 of about 10,320 (199)
CHEK1 and GFPT1 as Potential Blood-Based Biomarkers for Colorectal Cancer
Indonesian Biomedical Journal, 2023 BACKGROUND: The checkpoint kinase 1 (CHEK1) and glutamine-fructose-6-phosphate aminotransferase 1 (GFPT1) genes have been reported to have a crucial role in carcinogenesis in colorectal cancer (CRC).
Habibah Faroque +7 more
doaj +3 more sources
Frontiers in Genetics, 2022 In light of the limited number of targetable oncogenic drivers in breast cancer (BRCA), it is important to identify effective and druggable gene targets for the treatment of this devastating disease.
Daowu Yu +3 more
doaj +4 more sources
Associations of ATR and CHEK1 Single Nucleotide Polymorphisms with Breast Cancer [PDF]
PLoS ONE, 2013 DNA damage and replication checkpoints mediated by the ATR-CHEK1 pathway are key to the maintenance of genome stability, and both ATR and CHEK1 have been proposed as potential breast cancer susceptibility genes. Many novel variants recently identified by
Wei-Yu Lin, Jon Slate, Malcolm W R Reed
exaly +6 more sources
The Prevalence of CHEK1 and CHEK2 Mutations in Prostate Cancer: a Retrospective Cohort Study [PDF]
Medical Archives, 2023 Background: Prostate cancer (PCa) is one of the most common types of cancer among men. Mutations and accumulation of chromosomal deviations are correlated with the development and aggressiveness of PCa.
Mohammed Alorjani +7 more
semanticscholar +4 more sources
Gene Expression Alterations and Molecular Analysis of CHEK1 in Solid Tumors [PDF]
Cancers, 2020 Alterations in the Checkpoint kinase (CHEK1) gene, its regulation, and the possible clinical outcomes in human solid tumors have not been previously examined.
Olusola B Adewale +2 more
exaly +5 more sources
PLoS ONEEndometrial cancer is the most prevalent gynecologic malignancy with a high risk of recurrence. Local recurrence occurs in 7-20% of patients with treated stage I cancer within 3 years after primary treatment.
Liubov Buchynska +3 more
doaj +4 more sources
Cell Death Discovery, 2022 Currently, surgical extraction is the main therapy for cholangiocarcinoma (CCA) patients, but it’s highly susceptible to postsurgical complications and recurrence rate.
Nuo Li, Baoming Wang
doaj +3 more sources
Thiosemicarbazones Can Act Synergistically with Anthracyclines to Downregulate CHEK1 Expression and Induce DNA Damage in Cell Lines Derived from Pediatric Solid Tumors [PDF]
International Journal of Molecular Sciences, 2022 Anticancer therapy by anthracyclines often leads to the development of multidrug resistance (MDR), with subsequent treatment failure. Thiosemicarbazones have been previously suggested as suitable anthracycline partners due to their ability to overcome ...
Silvia Paukovčeková +5 more
openalex +2 more sources
Human Tra2 proteins jointly control a CHEK1 splicing switch among alternative and constitutive target exons [PDF]
Nature Communications, 2014 AbstractAlternative splicing—the production of multiple messenger RNA isoforms from a single gene—is regulated in part by RNA binding proteins. While the RBPs transformer2 alpha (Tra2α) and Tra2β have both been implicated in the regulation of alternative splicing, their relative contributions to this process are not well understood.
Katherine James, Tomaž Curk, Yaobo Xu
exaly +6 more sources
Thoracic Cancer, 2022 Background Non‐small‐cell lung cancer (NSCLC) is one of the most common malignant tumors on earth. Circular RNAs have been disclosed to be vital regulators in the chemoresistance and development of diverse cancers, including NSCLC.
Ming Jin +5 more
doaj +2 more sources