Results 21 to 30 of about 10,320 (199)
Frontiers in OncologyBackgroundGenome instability plays a crucial role in promoting tumor development. Germline mutations in genes responsible for DNA repair are often associated with familial cancer syndromes. A noticeable exception is the CHEK1 gene.
Jun Qian +8 more
doaj +2 more sources
Cellular and Molecular Biology, 2023 Diabetic nephropathy (DN) is considered to be a kidney disease caused by diabetes. In recent years, the incidence of DN has been on the rise, which is also a major challenge in the treatment and prognosis of the disease.
Dan Wang +4 more
semanticscholar +3 more sources
BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cells [PDF]
Blood Cells, Molecules, and Diseases, 2008 BCL6 is a transcriptional repressor protein that is expressed in a developmentally regulated fashion during B-cell maturation. Specifically, BCL6 is required for formation of germinal centers in response to T-cell dependent antigen activation. Germinal center B-cells feature the ability to tolerate rapid proliferation and simultaneous genetic ...
Jose M Polo, Ari M Melnick
exaly +4 more sources
Maternal heterozygous mutation in CHEK1 leads to mitotic arrest in human zygotes [PDF]
Protein & Cell, 2021 the experiments. JG, TW, QL, JM performed mouse embryo and oocytes collection and microinjection, phenotype analysis, embryo transfer and transcriptome pro fi ...
Beili Chen +10 more
semanticscholar +3 more sources
Herba Patriniae Component Linarin Induces Cell Cycle Arrest and Senescence in Non-Small-Cell Lung Cancer Associated with Cyclin A2 Downregulation [PDF]
PharmaceuticalsBackground: Non-small-cell lung cancer (NSCLC) remains a major therapeutic challenge due to its high incidence and mortality. Herba Patriniae (HP), a traditional Chinese medicine, has long been used for respiratory disorders and exhibits anti-cancer ...
Wen Xie +6 more
doaj +2 more sources
Identification of telomere maintenance related biomarkers and regulatory mechanisms in chronic obstructive pulmonary disease by machine learning algorithm [PDF]
Scientific ReportsChronic obstructive pulmonary disease (COPD) is a progressive respiratory disease that accelerates the aging process of the lung. Despite advancements in managing symptoms and preventing acute exacerbations, significant gaps remain in our understanding ...
Haiyan Cao, Xiangjian Chu
doaj +2 more sources
Olaparib for patients with tumors harboring alterations in homologous recombination repair genes: Results from the drug rediscovery protocol. [PDF]
Int J CancerWhat's new? PARP inhibitors are effective in patients with inactivating alterations in the BRCA1/2 genes across tumor types. However, the efficacy of PARP inhibitors in patients with other inactivated homologous recombination repair genes remains unclear. This knowledge gap and discrepancies in EMA/FDA approvals highlight the need for better biomarkers.
Spiekman IAC +15 more
europepmc +2 more sources
Translational Oncology, 2018 Accumulating evidence indicates that Checkpoint kinase 1 (CHEK1) plays an essential role in tumor cells and that it could induce cell proliferation and could be related to prognosis in multiple types of cancer.
Xiaobin Bai +6 more
doaj +3 more sources
Cancer Cell International, 2019 Background Long non-coding RNAs (lncRNAs) are a family of non-protein-coding RNAs, which have the ability to influence the chemo-resistance of lung adenocarcinoma (LAC).
Wei Zuo +4 more
doaj +2 more sources
B lymphocytes and tertiary lymphoid structures have a prognostic impact on penile squamous cell carcinoma. [PDF]
J Pathol Clin ResAbstract Several prognostic markers, including tumor‐infiltrating lymphocytes, which have been recently identified in penile squamous cell carcinoma (pSCC), have focused mostly on T cells. The prognostic role of B cells and tertiary lymphoid structures (TLSs) has not yet been sufficiently described. We examined whole tissue sections histopathologically
Zavillová N +8 more
europepmc +2 more sources