YX-112, a novel celastrol-derived PROTAC, inhibits the development of triple-negative breast cancer by targeting the degradation of multiple proteins [PDF]
Frontiers in PharmacologyBackgroundCelastrol is an effective component of the plant Tripterygium wilfordii Hook. f., which has a high inhibitory effect on triple-negative breast cancer.
Yongxue Gu +7 more
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The role of senescence-related hub genes correlating with immune infiltration in type A aortic dissection: Novel insights based on bioinformatic analysis. [PDF]
PLoS ONEBackgroundStanford type A aortic dissection (AAD) is a fatal disease that confers extremely high morbidity and mortality. Cellular senescence, characterized by a permanent cell cycle arrest, has been implicated in the onset and progression of ...
Wei He, Panli Tang
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Profiling genetic mutations in the DNA damage repair genes of oral squamous cell carcinoma patients from Pakistan [PDF]
Scientific ReportsHerein, we reported mutations in five DNA Damage Repair (DDR) i.e., TP53 , ATR , ATM, CHEK1 and CHEK2 involved in OSCC using NG-WES and their analysis using bioinformatics tools. Out of 42 identified mutations, 16.7% are reported for the 1st time.
Wafa Naeem +12 more
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Meta-Analysis and Experimental Studies Reveal Mitotic Network Activity Index (MNAI) as Breast Cancer Metastasis and Treatment Biomarker [PDF]
LifeObjective: Identifying biomarkers that predict metastatic potential or guide treatment selection is critical for improving breast cancer (BC) management.
Yimeng Cai +3 more
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Potential Therapeutic Targets in Triple-Negative Breast Cancer Based on Gene Regulatory Network Analysis: A Comprehensive Systems Biology Approach [PDF]
International Journal of Breast CancerConclusion: This study provides insights into the molecular mechanisms of TNBC and suggests CHEK1, PLK1, and their upstream regulators as potential therapeutic targets for TNBC treatment.
Maryam Ahmadi +3 more
doaj +2 more sources
Altered TP53, CDKN2A, ATM, EPHA7, POT1, CHEK1, GRIN2A, and EGFR Predict Shorter Survival in Penile Squamous Cell Carcinoma [PDF]
Modern PathologyJ. Hojný +10 more
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Targeting CDC25C, PLK1 and CHEK1 to overcome Docetaxel resistance induced by loss of LZTS1 in prostate cancer [PDF]
Oncotarget, 2014 Frédéric Commo, Anne Chauchereau
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MiR-195 suppresses non-small cell lung cancer by targeting CHEK1 [PDF]
Oncotarget, 2015 MiR-195 suppresses tumor growth and is associated with better survival outcomes in several malignancies including non-small cell lung cancer (NSCLC). Our previous study showed high miR-195 plasma levels associated with favorable overall survival of non-smoking women with lung adenocarcinoma.
Ben Liu +6 more
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Bioorganic and Medicinal Chemistry Letters, 2006 James Hardwick, Laura Sepp-Lorenzino
exaly +2 more sources
, 2023 <div>Abstract<p>Ovarian cancer is characterized by frequent mutations at TP53. These tumors also harbor germline mutations at homologous recombination repair genes, so they rely on DNA-damage checkpoint proteins, like the checkpoint kinase 1 (CHEK1) to induce G<sub>2</sub> arrest. In our study, by using an <i>in silico</
Ana Alcaráz-Sanabria +10 more
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