Results 41 to 50 of about 10,320 (199)

Figure S2 from Synthetic Lethality Interaction Between Aurora Kinases and CHEK1 Inhibitors in Ovarian Cancer

, 2023
<p>Alisertib and LY2603618 impair formation of colonies and induce citotoxicity in ovarian cancer cells.</p>
Ana Alcaráz-Sanabria, Cristina Nieto‐Jiménez, Verónica Corrales‐Sánchez, Leticia Serrano‐Oviedo, Fernando Andrés‐Pretel, Juan Carlos Montero, Miguel Burgos, Juan Llopis, Eva María Galán‐Moya, Atanasio Pandiella, Alberto Ocaña   +10 more
openalex   +2 more sources

Synthetic Lethality Interaction Between Aurora Kinases and CHEK1 Inhibitors in Ovarian Cancer [PDF]

Molecular Cancer Therapeutics, 2017
Abstract Ovarian cancer is characterized by frequent mutations at TP53. These tumors also harbor germline mutations at homologous recombination repair genes, so they rely on DNA-damage checkpoint proteins, like the checkpoint kinase 1 (CHEK1) to induce G2 arrest.
Alcaraz-Sanabria, Ana, Nieto-Jiménez, Cristina, Corrales-Sánchez, Verónica, Serrano-Oviedo, Leticia, Andrés-Pretel, Fernando, Montero, Juan Carlos, Burgos, Miguel, Llopis, Juan, Galán-Moya, Eva María, Pandiella, Atanasio, Ocaña, Alberto   +10 more
openaire   +5 more sources

Upregulation of the ATR‐CHEK1 pathway in oral squamous cell carcinomas [PDF]

Genes, Chromosomes and Cancer, 2013
The ATR‐CHEK1 pathway is upregulated and overactivated in Ataxia Telangiectasia (AT) cells, which lack functional ATM protein. Loss of ATM in AT confers radiosensitivity, although ATR‐CHEK1 pathway overactivation compensates, leads to prolonged G2 arrest after treatment with ionizing radiation (IR), and partially reverses the radiosensitivity.
Rahul A, Parikh, Leonard J, Appleman, Julie E, Bauman, Madhav, Sankunny, Dale W, Lewis, Anda, Vlad, Susanne M, Gollin   +6 more
openaire   +2 more sources

Identification of CDK1, PBK, and CHEK1 as an Oncogenic Signature in Glioblastoma: A Bioinformatics Approach to Repurpose Dapagliflozin as a Therapeutic Agent

International Journal of Molecular Sciences, 2023
Glioblastoma multiforme (GBM) is the most aggressive and lethal primary brain tumor whose median survival is less than 15 months. The current treatment regimen comprising surgical resectioning, chemotherapy with Temozolomide (TMZ), and adjuvant ...
H. A. Chinyama, Li Wei, Ntlotlang Mokgautsi, B. Lawal, A. Wu, Hsu-Shan Huang   +5 more
semanticscholar   +1 more source

Lipid raft‐disrupting miltefosine preferentially induces the death of colorectal cancer stem‐like cells

Clinical and Translational Medicine, 2021
Background Lipid rafts (LRs), cholesterol‐enriched microdomains on cell membranes, are increasingly viewed as signalling platforms governing critical facets of cancer progression.
So‐Yeon Park, Jee‐Heun Kim, Jang‐Hyun Choi, Choong‐Jae Lee, Won‐Jae Lee, Sehoon Park, Zee‐Yong Park, Jeong‐Heum Baek, Jeong‐Seok Nam   +8 more
doaj   +1 more source

Identifying the Key Genes in Mouse Liver Regeneration After Partial Hepatectomy by Bioinformatics Analysis and in vitro/vivo Experiments

Frontiers in Genetics, 2021
BackgroundThe liver is the only organ that can completely regenerate after various injuries or tissue loss. There are still a large number of gene functions in liver regeneration that have not been explored.
Jian Zhao, Shi-Zhe Yu, Qiang Cai, Duo Ma, Long Jiang, Ling-Peng Yang, Zhi-Yong Yu   +6 more
doaj   +1 more source

Topotecan synergizes with CHEK1 (CHK1) inhibitor to induce apoptosis in ovarian cancer cells [PDF]

BMC Cancer, 2015
Topotecan (TPT) is a therapeutic option for women with platinum-resistant or -refractory ovarian cancer. However, the dose-limiting toxicity of TPT is myelosuppression. This led us to seek a combination treatment to augment TPT anti-cancer activity in a cancer-targeted manner.
Kim, Marianne K, James, Jana, Annunziata, Christina M   +2 more
openaire   +3 more sources

Identification of hub genes and their correlation with infiltration of immune cells in MYCN positive neuroblastoma based on WGCNA and LASSO algorithm

Frontiers in Immunology, 2022
BackgroundThe prognosis of MYCN positive NB is poor, and there is no targeted drug for N-myc at present. This study aims to screen out hub genes closely related to MYCN, analyze the relationship between hub genes and NB microenvironment, and provide ...
Ji Chen, Mengjiao Sun, Chuqin Chen, Bin Jiang, Yongjun Fang   +4 more
doaj   +1 more source

The mitotic checkpoint is a targetable vulnerability of carboplatin-resistant triple negative breast cancers

Scientific Reports, 2021
Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype, lacking effective therapy. Many TNBCs show remarkable response to carboplatin-based chemotherapy, but often develop resistance over time.
Stijn Moens, Peihua Zhao, Maria Francesca Baietti, Oliviero Marinelli, Delphi Van Haver, Francis Impens, Giuseppe Floris, Elisabetta Marangoni, Patrick Neven, Daniela Annibali, Anna A. Sablina, Frédéric Amant   +11 more
doaj   +1 more source

Identification of a Novel Survival-Related circRNA–miRNA–mRNA Regulatory Network Related to Immune Infiltration in Liver Hepatocellular Carcinoma

Frontiers in Genetics, 2022
Increasing studies have reported that circular RNAs (circRNAs) play critical roles in tumorigenesis and cancer progression. However, the underlying regulatory mechanisms of circRNA-related competing endogenous RNA (ceRNA) in liver hepatocellular ...
Yu Gan, Yu Gan, Weidan Fang, Weidan Fang, Yan Zeng, Yan Zeng, Peijun Wang, Peijun Wang, Renfeng Shan, Ling Zhang, Ling Zhang, Ling Zhang   +11 more
doaj   +1 more source