Results 51 to 60 of about 10,320 (199)

Aberrant Activation of Cell-Cycle–Related Kinases and the Potential Therapeutic Impact of PLK1 or CHEK1 Inhibition in Uterine Leiomyosarcoma

Clinical Cancer Research, 2022
Purpose: Uterine leiomyosarcoma is among the most aggressive gynecological malignancies. No effective treatment strategies have been established. This study aimed to identify novel therapeutic targets for uterine leiomyosarcoma based on transcriptome ...
Kosuke Yoshida, Akira Yokoi, Tomofumi Yamamoto, Yusuke Hayashi, J. Nakayama, Tsuyoshi Yokoi, Hiroshi Yoshida, Tomoyasu Kato, H. Kajiyama, Yusuke Yamamoto   +9 more
semanticscholar   +1 more source

Supplementary Figure from Aberrant Activation of Cell-Cycle–Related Kinases and the Potential Therapeutic Impact of PLK1 or CHEK1 Inhibition in Uterine Leiomyosarcoma

, 2023
Kosuke Yoshida, Akira Yokoi, Tomofumi Yamamoto, Yusuke Hayashi, Jun Nakayama, Tsuyoshi Yokoi, Hiroshi Yoshida, Tomoyasu Kato, Hiroaki Kajiyama, Yusuke Yamamoto   +9 more
  +6 more sources

RETRACTED: Silencing Long Non-coding RNA LINC01224 Inhibits Hepatocellular Carcinoma Progression via MicroRNA-330-5p-Induced Inhibition of CHEK1

Molecular Therapy: Nucleic Acids, 2019
Dan Gong, Pengcheng Feng, Xing-Fei Ke, Hui-Lan Kuang, Lili Pan, Qiang Ye, Jian-Bing Wu   +6 more
openalex   +2 more sources

RETRACTED: Frequent alterations of LOH11CR2A, PIG8 and CHEK1 genes at chromosomal 11q24.1‐24.2 region in breast carcinoma: Clinical and prognostic implications

Molecular Oncology, 2011
To understand the importance of frequent deletions at chromosome 11q24.1‐24.2 region in breast carcinoma, alterations (deletion/methylation) of the candidate genes LOH11CR2A, ROBO3, ROBO4, HEPACAM, PIG8 and CHEK1 located in this region were analyzed in ...
Satyabrata Sinha, Ratnesh K. Singh, Nilanjana Bhattacharya, Nupur Mukherjee, Susmita Ghosh, Neyaz Alam, Anup Roy, Susanta Roychoudhury, Chinmay Kumar Panda   +8 more
doaj   +1 more source

Figure S3 from Synthetic Lethality Interaction Between Aurora Kinases and CHEK1 Inhibitors in Ovarian Cancer

, 2023
<p>Combination of Alisertib and LY2603618 induced G2/M arrest in SKOV3.</p>
Ana Alcaráz-Sanabria, Cristina Nieto‐Jiménez, Verónica Corrales‐Sánchez, Leticia Serrano‐Oviedo, Fernando Andrés‐Pretel, Juan Carlos Montero, Miguel Burgos, Juan Llopis, Eva María Galán‐Moya, Atanasio Pandiella, Alberto Ocaña   +10 more
openalex   +2 more sources

CHEK1 coordinates DNA damage signaling and meiotic progression in the male germline of mice [PDF]

Human Molecular Genetics, 2018
The continuity of life depends on mechanisms in the germline that ensure the integrity of the genome. The DNA damage response/checkpoint kinases ATM and ATR are essential signaling factors in the germline. However, it remains unknown how a downstream transducer, Checkpoint Kinase 1 (CHEK1 or CHK1), mediates signaling in the male germline. Here, we show
Abe, Hironori, Alavattam, Kris G, Kato, Yasuko, Castrillon, Diego H, Pang, Qishen, Andreassen, Paul R, Namekawa, Satoshi H   +6 more
openaire   +4 more sources

Hsp90-associated DNA replication checkpoint protein and proteasome-subunit components are involved in the age-related macular degeneration

Chinese Medical Journal, 2021
. Background:. Age-related macular degeneration (AMD) is the leading cause of vision loss worldwide. However, the mechanisms involved in the development and progression of AMD are poorly delineated.
Chen Xing, Xiao-Feng Liu, Chun-Feng Zhang, Liu Yang, Yan-Jie Yin, Xiu-Yuan Hao   +5 more
doaj   +1 more source

Targeting DNA damage response deficiency in the treatment of breast cancer [PDF]

Zhongguo aizheng zazhi, 2022
DNA damage response (DDR) deficiency has been one of the emerging targets in treating breast cancer in recent years. The DDR pathway is essential for the identification, signal transduction and repair of DNA damage.
JIN Yizi, LIN Mingxi, ZHANG Jian
doaj   +1 more source

Genetic variants of CHEK1, PRIM2 and CDK6 in the mitotic phase‐related pathway are associated with nonsmall cell lung cancer survival

International Journal of Cancer, 2021
The mitotic phase is a vital step in cell division and may be involved in cancer progression, but it remains unclear whether genetic variants in mitotic phase‐related pathways genes impact the survival of these patients.
Rui Mu, Hongliang Liu, S. Luo, E. Patz, C. Glass, L. Su, Mulong Du, D. Christiani, Lei Jin, Q. Wei   +9 more
semanticscholar   +1 more source

A Key mRNA-miRNA-lncRNA Competing Endogenous RNA Triple Sub-network Linked to Diagnosis and Prognosis of Hepatocellular Carcinoma

Frontiers in Oncology, 2020
Growing evidence has illustrated critical roles of competing endogenous RNA (ceRNA) regulatory network in human cancers including hepatocellular carcinoma.
Junjie Zhang, Weiyang Lou
doaj   +1 more source