Results 61 to 70 of about 10,320 (199)

Involvement of MiRNA-211-5p and Arhgap11a Interaction During Osteogenic Differentiation of MC3T3-E1 Cells

Frontiers in Surgery, 2022
ObjectiveMicroRNAs (miRNAs) are well-recognized for their abilities to regulate gene expression post-transcriptionally in plants and animals. Recently, miRNA-messenger RNA (mRNA) regulatory relationships have been confirmed during biological processes ...
Wenwen Ju, Guangfeng Zhang, Xu Zhang, Jingting Wang, Tong Wu, Huafeng Li   +5 more
doaj   +1 more source

Isovalerylspiramycin I inhibits proliferation, migration and invasion of osteosarcoma cells by targeting Topoisomerase 1 and suppressing the ataxia telangiectasia and Rad3‐related/checkpoint kinase 1 pathway

Clinical and Translational Discovery, 2023
Purpose Topoisomerase 1 (TOP1) plays a crucial role in various cell cycle processes and its dysregulation can lead to the development of multiple tumours.
Jinrong Liang, Peng Zhang, Kunyan He, Yawen Zhang, Xiaomin Ding, Qian Li, Wang Zhou, Haiyan Hu, Jianjun Zhang, Yan Zhou   +9 more
doaj   +1 more source

Untangling the ATR‐CHEK1 network for prognostication, prediction and therapeutic target validation in breast cancer [PDF]

Molecular Oncology, 2014
ATR‐CHEK1 signalling is critical for genomic stability. ATR‐CHEK1 signalling may be deregulated in breast cancer and have prognostic, predictive and therapeutic significance. We investigated ATR, CHEK1 and phosphorylated CHEK1 Ser345 protein (pCHEK1) levels in 1712 breast cancers. ATR and CHEK1 mRNA expression was evaluated in 1950 breast cancers.
Abdel-Fatah, TMA, Middleton, FK, Arora, A, Agarwal, D, Chen, T, Moseley, PM, Perry, C, Doherty, R, Chan, S, Green, AR, Rakha, E, Ball, G, Ellis, IO, Curtin, NJ, Madhusudan, S   +14 more
openaire   +4 more sources

AURKB, CHEK1 and NEK2 as the Potential Target Proteins of Scutellaria barbata on Hepatocellular Carcinoma: An Integrated Bioinformatics Analysis

International Journal of General Medicine, 2021
Objective We aim to explore the potential anti-HCC mechanism of Scutellaria barbata through integrated bioinformatics analysis. Methods We searched active ingredients and related targets of Scutellaria barbata via TCMSP database, PubChem and ...
Chaoyuan Huang, Hu Luo, Yuancheng Huang, Chongkai Fang, Lina Zhao, Peiwu Li, Chong Zhong, Fengbin Liu   +7 more
semanticscholar   +1 more source

Proteogenomic Characterization Reveals Subtype‐Specific Therapeutic Potential for HER2‐Low Breast Cancer

Advanced Science, EarlyView.
Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu, Keda Yu, Lei Liu, Qin Wang, Xiaohui Wu, Yihai Chen, Guozheng Li, Xin Zhang, Bo Wei, Zitong Fu, Abiyasi Nanding, Zuxianglan Zhao, Lingbing Yang, Xingda Zhang, Jianyu Wang, Wantong Sun, Yi Hao, Zhongyi Cheng, Xiaojiang Cui, Hao Wu, Da Pang   +20 more
wiley   +1 more source

Comprehensive analysis of potential ceRNA network and immune cell infiltration in intervertebral disc degeneration

Journal of Orthopaedic Surgery and Research, 2022
Background Intervertebral disc degeneration (IDD) has become a serious public health problem, the mechanism of which is complex and still unclear. We aimed to construct a ceRNA network related to IDD to explore its pathogenesis. Methods We downloaded the
Xiaoyang Fang, Tian Tang, Daoxi Sun, Shuang Chen, Nan Wang, Lin Xie   +5 more
doaj   +1 more source

Optic nerve sheath meningioma exhibits neural niche‐associated transcriptomic features and rare copy number variation‐linked evolution

Brain Pathology, EarlyView.
Optic nerve sheath meningiomas are typically NF2‐intact with few copy number alterations and are generally clinically indolent. Rare aggressive recurrences are associated with progressive accumulation of copy number variations, including CDKN2A/B homozygous deletion, 1q gain, and 14q loss.
Daisuke Sato, Satoru Miyawaki, Yu Sakai, Kenta Ohara, Yu Teranishi, Yudai Hirano, Motoyuki Umekawa, Takahiro Tsuchiya, Shotaro Ogawa, So Hirata, Hiroki Hongo, Hideaki Ono, Daisuke Komura, Tetsuo Ushiku, Shumpei Ishikawa, Nobuhito Saito   +15 more
wiley   +1 more source

Identification and validation of key genes with prognostic value in non‐small‐cell lung cancer via integrated bioinformatics analysis

Thoracic Cancer, 2020
Background Lung cancer is the most common cause of cancer‐related death among all human cancers and the five‐year survival rates are only 23%. The precise molecular mechanisms of non‐small cell lung cancer (NSCLC) are still unknown. The aim of this study
Li Wang, Jialin Qu, Yu Liang, Deze Zhao, Faisal UL Rehman, Kang Qin, Xiaochun Zhang   +6 more
doaj   +1 more source

Cell cycle arrest is an important mechanism of action of compound Kushen injection in the prevention of colorectal cancer

Scientific Reports, 2022
Compound Kushen injection (CKI) is the most widely used traditional Chinese medicine preparation for the comprehensive treatment of colorectal cancer (CRC) in China, but its underlying molecular mechanisms of action are still unclear.
Jie Sun, Mei Li, Tingru Lin, Di Wang, Jingyi Chen, Yu Zhang, Qing Mu, Huiting Su, Na Wu, Aiyu Liu, Yimeng Yu, Yulan Liu, Shaojie Wang, Xin Yu, Jingzhu Guo, Weidong Yu   +15 more
doaj   +1 more source

Knockdown of MRPL35 promotes cell apoptosis and inhibits cell proliferation in non-small-cell lung cancer

BMC Pulmonary Medicine, 2023
Background Non-small cell lung cancer (NSCLC) is a major pathological type of lung cancer. However, its pathogenesis remains largely unclear. MRPL35 is a regulatory subunit of the mitoribosome, which can regulate the assembly of cytochrome c oxidases and
Chengling Zhao, Lei Chen, Zhixin Jin, Haitao Liu, Chao Ma, Hangtian Zhou, Lingling Xu, Sihui Zhou, Yan Shi, Wei Li, Yuqing Chen, Chengli Dou, Xiaojing Wang   +12 more
doaj   +1 more source