Results 71 to 80 of about 10,320 (199)
Bayesian Model Infers Drug Repurposing Candidates for Treatment of COVID-19
Applied Sciences, 2021 The emergence of COVID-19 progressed into a global pandemic that has functionally put the world at a standstill and catapulted major healthcare systems into an overburdened state.
Michael A. Kiebish +10 more
doaj +1 more source
British Journal of Pharmacology, Volume 183, Issue 5, Page 1122-1139, March 2026.Abstract Background and Purpose Mavacamten (MAVA) is a novel small molecule inhibitor of cardiac myosin, mitigating cardiomyocyte hypercontractility in patients with hypertrophic obstructive cardiomyopathy (HOCM). Despite its recent approval for clinical use, the transcriptional and functional impacts of MAVA remain not well understood.
Elisa Kiselev +36 more
wiley +1 more source
Deciphering the Transcriptomic Signatures of Aging Across Organs in Mice
Aging Cell, Volume 25, Issue 2, February 2026.Comprehensive transcriptomic profiling of eight mouse organs across six ages reveals how aging reshapes biological processes. Trajectory and network analyses distinguish shared and organ‐specific signatures, charting the molecular landscape of systemic aging.
Sarah Morsy +9 more
wiley +1 more source
The Journal of Pathology: Clinical Research, Volume 12, Issue 1, January 2026.Abstract Uterine tumor resembling ovarian sex cord tumor (UTROSCT) constitutes an exceptionally rare histological subset of uterine mesenchymal neoplasms. While most cases have benign clinical behavior, a subset of UTROSCTs exhibits clinically aggressive behavior characterized by recurrence and metastasis.
Jing Yang +6 more
wiley +1 more source
Scientific Reports, 2022 Atopic dermatitis (AD) is a common, chronic inflammatory dermatosis with relapsing eruptions. Our study used bioinformatics to find novel candidate differentially expressed genes (DEGs) and predicted miRNAs between AD patients and healthy controls.
LiangHong Chen +8 more
doaj +1 more source
Frontiers in Oncology, 2023 Although epidermoid cysts are frequently seen as benign lesions, they are highly uncommon to develop into cancerous lesions. A 36-year-old man with a cystic mass present on his left flank since childhood presented to our department.
Woosuk Choi +3 more
doaj +1 more source
Advanced Science, Volume 13, Issue 4, 19 January 2026.This study provides a multi‐omics landscape of treatment‐naïve colorectal liver metastasis and reveals dysregulated molecules and cellular pathways. SHMT1 and NDRG1 Ser330 phosphorylation are demonstrated to display crucial roles in tumorigenesis and liver metastasis. Two proteomics subtypes (metabolism and RNA function) with distinct clinical outcomes
Wensi Zhao +20 more
wiley +1 more source
Exploiting the molecular basis of age and gender differences in outcomes of SARS-CoV-2 infections
Computational and Structural Biotechnology Journal, 2021 Motivation: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (coronavirus disease, 2019; COVID-19) is associated with adverse outcomes in patients.
Daniele Mercatelli +4 more
doaj +1 more source
MedComm, Volume 7, Issue 1, January 2026.The management of cancer and tissue regeneration remains a substantial challenge to global health. Organoids, which are stem cell‐derived three‐dimensional multicellular structures, are revolutionizing biomedical research. Therefore, this review highlights their applications in cancer research and regenerative medicine, while discussing current ...
Ruiyang Li +5 more
wiley +1 more source
Blood, 2020 Key findings CHEK1 and circCHEK1_246aa induce multiple myeloma cell proliferation, drug resistance, and bone lesion formation CHEK1 and circCHEK1_246aa evoke myeloma chromosomal instability, partially through CEP170 activation Abstract Multiple myeloma (MM) is characterized by clonal expansion
Ye Yang +3 more
openaire +1 more source