Results 81 to 90 of about 10,320 (199)

Lipid Droplet‐Driven Ribosome Collisions Trigger ZAKα‐p38 Signaling to Accelerate Testicular Aging

Aging Cell, Volume 25, Issue 1, January 2026.
Aging‐ and obesity‐driven lipid droplet accumulation in Sertoli cells induces ROS‐mediated ribosome collisions, activating the ZAKα‐p38 pathway to accelerate testicular aging. Pharmacological ZAKα inhibition with Nilotinib rescues age‐related testicular dysfunction, identifying ribotoxic stress as a therapeutic target.
Yanghua Xu, Xiaoyan Shi, Yinghao Yin, Xiaoli Tan, Ningjing Ou, Xiaopeng Tang, Biao Liu, Hongshan Xie, Yuzhuo Chen, Zhitao Han, Jiarong Xu, Zitaiyu Li, Xiaoping Zheng, Hongji Hu, Wenjing Wang, Wanyi Xia, Hao Chen, Yuxin Tang, Liangyu Zhao   +18 more
wiley   +1 more source

Identification of novel alternative splicing isoform biomarkers and their association with overall survival in colorectal cancer

BMC Gastroenterology, 2020
Background Alternative splicing (AS) is an important mechanism of regulating eukaryotic gene expression. Understanding the most common AS events in colorectal cancer (CRC) will help developing diagnostic, prognostic or therapeutic tools in CRC.
Haifeng Lian, Aili Wang, Yuanyuan Shen, Qian Wang, Zhenru Zhou, Ranran Zhang, Kun Li, Chengxia Liu, Hongtao Jia   +8 more
doaj   +1 more source

Predictive signature of response to neoadjuvant chemotherapy in muscle-invasive bladder cancer integrating mRNA expression, taxonomic subtypes, and clinicopathological features

Frontiers in Oncology, 2023
Background and objectiveNeoadjuvant chemotherapy (NAC) followed by cystectomy is the standard of care in muscle-invasive bladder cancer (MIBC). Pathological response has been associated with longer survival, but no currently available clinicopathological
Albert Font, Albert Font, Montserrat Domenech, Jose Luis Ramirez, Miriam Marqués, Raquel Benítez, Vicenç Ruiz de Porras, Vicenç Ruiz de Porras, José L. Gago, Cristina Carrato, Francesc Sant, Hector Lopez, Daniel Castellano, Nuria Malats, M. Luz Calle, Francisco X. Real, Francisco X. Real, Francisco X. Real   +17 more
doaj   +1 more source

Combination of CHEK1/2 Inhibition and Ionizing Radiation Results in Abscopal Tumor Response through Increased Micronuclei Formation

Oncogene, 2020
We explore a novel strategy of activating immune signaling through increased micronuclei formation utilizing a cell cycle checkpoint inhibitor to drive cell cycle progression following ionizing radiation.
H. Chao, Ilias V. Karagounis, Christoforos Thomas, Noelle B. Francois, A. Facciabene, C. Koumenis, A. Maity   +6 more
semanticscholar   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, Volume 19, Issue 12, Page 3486-3498, December 2025.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Identifizierung eines Moleküls, das den Abbau der aktivierten Checkpoint‐Kinase‐1 auslöst und Charakterisierung der nicht‐katalytischen Funktionen von Checkpoint‐Kinase‐1 in Tumorzellen

Angewandte Chemie, Volume 137, Issue 49, December 1, 2025.
In Tumorzellen führt die durch HU induzierte Verlangsamung der DNA‐Replikation zur Aktivierung von CHK1 durch Autophosphorylierung, was einen Zellzyklusarrest bewirkt und die Rekrutierung des DNA‐Reparaturproteins WRN zur Förderung der DNA‐Reparatur und des Zellüberlebens ermöglicht.
Ramy Ashry, Mohamed Abdelsalam, Julia Hausen, Christoph Hieber, Yanira Zeyn, Anne‐Christin Sarnow, Matthias Schmidt, Sara Najafi, Ina Oehme, Matthias Bros, Jia‐Xuan Chen, Mario Dejung, Wolfgang Sippl, Oliver H. Krämer   +13 more
wiley   +1 more source

Identification of a Proteolysis‐Targeting‐Chimera that Addresses Activated Checkpoint Kinase‐1 Reveals its Non‐Catalytic Functions in Tumor Cells

Angewandte Chemie International Edition, Volume 64, Issue 49, December 1, 2025.
In cancer cells, the induction of DNA replication stress by HU activates CHK1 by autophosphorylation. This leads to cell cycle arrest and recruits the DNA repair protein WRN to promote DNA repair and cell survival. In such cells, addition of the CHK1 inhibitor 9a propels DNA damage and apoptosis.
Ramy Ashry, Mohamed Abdelsalam, Julia Hausen, Christoph Hieber, Yanira Zeyn, Anne‐Christin Sarnow, Matthias Schmidt, Sara Najafi, Ina Oehme, Matthias Bros, Jia‐Xuan Chen, Mario Dejung, Wolfgang Sippl, Oliver H. Krämer   +13 more
wiley   +1 more source

Supplementary Table 1 from Thymoquinone Triggers Inactivation of the Stress Response Pathway Sensor <i>CHEK1</i> and Contributes to Apoptosis in Colorectal Cancer Cells [PDF]

, 2023
Hala Gali‐Muhtasib, Doerthe Kuester, Christian Mawrin, Khuloud Bajbouj, Antje Diestel, Matthias Ocker, Caroline Habold, Charlotte Foltzer‐Jourdainne, Peter Schoenfeld, Brigitte Peters, Mona Diab‐Assaf, Ulf Pommrich, Wafica Itani, H. Lippert, Albert Roessner, Regine Schneider‐Stock   +15 more
openalex   +1 more source

Robust multitask feature learning with adaptive Huber regressions

Canadian Journal of Statistics, Volume 53, Issue 4, December 2025.
Abstract When data from multiple tasks have outlier contamination, existing multitask learning methods perform less efficiently. To address this issue, we propose a robust multitask feature learning method by combining the adaptive Huber regression tasks with mixed regularization. The robustification parameters can be chosen to adapt to the sample size,
Yuan Zhong, Xin Gao, Wei Xu
wiley   +1 more source

Transcriptional Regulation of Microglial Metabolic and Activation States by P2RY12

Glia, Volume 73, Issue 12, Page 2464-2482, December 2025.
Main Points Transcriptionally, P2RY12‐deficient microglia show heightened metabolic activity, iron handling and oxidative stress at baseline. Upon LPS challenge, impaired glutathione antioxidant responses suggest increased vulnerability to ferroptosis. ABSTRACT Microglia are the resident immune cells of the CNS.
Aida Oryza Lopez‐Ortiz, Madison Doceti, JaQuinta Thomas, Abigayle Duffy, Morgan Coburn, Akhabue K. Okojie, Audrey Lee, Elizabeth Aidita Sou, Alban Gaultier, Ukpong B. Eyo   +9 more
wiley   +1 more source