Results 161 to 170 of about 136,503 (303)

Iron and Copper Homeostasis in Cardiometabolic Disease: Therapeutic Potential of Chelators. [PDF]

Pharmaceuticals (Basel)
Lachowicz JI, Gać P.
europepmc   +1 more source

Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions

Advanced Science, EarlyView.
This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang, Wenzhi Wang, Dongjiao Wang, Qibin Wu, Youxiong Que   +4 more
wiley   +1 more source

Technology Access and Preferences for Smartphone App Interventions to Optimize Iron Chelation Therapy Adherence Among Adolescents, Young Adults, and Parents of Children Receiving Chronic Transfusions: Cross-Sectional Survey Study. [PDF]

JMIR Pediatr Parent
Reddy P, Locke M, Badawy S.
europepmc   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Impact of iron chelation therapy on thyroid function in beta-thalassemia major patients from Pakistan. [PDF]

Sci Rep
Shah AWA, Shams S, Khan MJ, Ullah N, Ullah MJ, Inayat F.   +5 more
europepmc   +1 more source

Dual‐Targeting Cuproptosis and Mitophagy via a Flavopiridol‐Copper Nanoplatform Potentiates Immunotherapy Against Uveal Melanoma

Advanced Science, EarlyView.
This study develops a GSH‐responsive nanoplatform, NP@Fla‐Cu, to co‐activate cuproptosis and excessive mitophagy in uveal melanoma. The nanoplatform enhances tumor‐specific copper delivery, depletes antioxidant defenses, and remodels the tumor immune microenvironment.
Hong Ren, Zhihong Deng, Sheng Lu, Jing Zhang, Wenbin Liu, Jia Tan   +5 more
wiley   +1 more source

Impact of Smear Layer Removal Using Etidronate- and EDTA-Based Irrigation Protocols on Root Canal Microbiota: An In Vivo Study. [PDF]

Dent J (Basel)
Razumova S, Brago A, Kryuchkova A, Khakimova Z, Khabibova N, Volkov A, Barakat H, Dikopova N.   +7 more
europepmc   +1 more source

Metal catalyzed rearrangement of a 2,2'-bipyridine Schiff-base ligand to a quaterpyridine-type complex [PDF]

, 2007
Champouret, Connor, Constable, Coronado, Dell'Amico, France, Fukuzumi, Helen Stoeckli-Evans, Jian Wang, Joan C. Halfpenny, John D. Wallis, Mahrwald, Melanie Pilkington, Padhi, Pilkington, Pilkington, Rice, Stuart Onions, Wang, Wang, Yang, Zang   +21 more
core   +1 more source

Chemically Engineered L. reuteri Delivering αPD‐L1 and Gallium Ions via Metal‐Phenolic Networks Potentiate Anti‐Tumor Immunity and Ferroptosis

Advanced Science, EarlyView.
A multifaceted chemical strategy, integrating bacterial tropism, metal‐ion interference therapy, and immunotherapy, resulted in significant tumor regression in murine models. A pioneering paradigm for the design of biohybrid materials was established, highlighting how sophisticated chemical engineering of living systems can unlock new avenues for ...
Tingting Zhang, Mengyi Xu, Yan Zhang, Zhiwen Li, Danqing Song, Jing Pang, Ke Li, Yanxiang Wang   +7 more
wiley   +1 more source

Local Lung HIF-1α and VEGF Activation to Reverse Emphysema by a Sulfated Caffeic Acid Dehydropolymer. [PDF]

Biology (Basel)
Truong TM, Thompson ML, Desai UR, Sakagami M.   +3 more
europepmc   +1 more source