Results 211 to 220 of about 66,247 (299)

Glycolytic Enzyme HK2 Phosphorylates nSMase1 to Promote Astrocytic Exosomes Biogenesis Contributing to Acute Ischemic Stroke Injury

open access: yesAdvanced Science, EarlyView.
This study reveals that the glycolytic enzyme HK2 mediates hypoxia‐induced astrocytic exosome biogenesis by directly phosphorylating nSMase1. These astrocytic exosomes impair brain endothelial tight junctions. Astrocyte‐specific knockdown of HK2 reduces exosome release and alleviates brain injury after MCAO.
Chen Chen   +12 more
wiley   +1 more source

N,N- and N,O-Bidentate-Chelation-Assisted Alkenyl C-H Functionalization. [PDF]

open access: yesMolecules
Zhang Y   +6 more
europepmc   +1 more source

Lead chelation therapy and urate excretion in patients with chronic renal diseases and gout

open access: bronze, 2001
Ja‐Liang Lin   +3 more
openalex   +1 more source

Electronic Microenvironment Regulation of Bismuth‐salophen Single‐site Catalysts for Enhanced Selectivity in CO2 Electrolysis to Formic Acid

open access: yesAdvanced Science, EarlyView.
The microenvironment modulation of Bi SSCs via electronegative group (─F/─H/─OMe) modification demonstrably suppresses the HER at high current densities, achieving a HCOOH FE of 95%. The ─F group optimizes the electronic structure of Bi, significantly enhancing CO2 adsorption and reducing the energy barrier for *OCHO intermediate formation, thereby ...
Tianxing Wang   +12 more
wiley   +1 more source

Clinical Features, Molecular Biology, and the Metastatic Microenvironment in Lung Cancer Brain Metastases: Implications for Treatment Decisions

open access: yesAdvanced Science, EarlyView.
Brain metastases (BM) from lung cancer are aggressive with poor prognosis. This review covers clinical features, diagnosis, early metastasis, and multi‐omics‐elucidated mechanisms, especially the tumor microenvironment of lung cancer with BM. It also discusses preclinical models, signaling pathways, and emerging therapies.
Yixiang Zhu   +5 more
wiley   +1 more source

Intrathecal Baclofen Therapy Improves Refractory Status Dystonicus in Neuro-hepatic Wilson's Disease: A Case Report. [PDF]

open access: yesNMC Case Rep J
Yamanaka S   +6 more
europepmc   +1 more source

Ferrocene‐Functionalized Black Phosphorus Nanoplatform Enables Targeted and Prolonged MRI Visualization of Atherosclerotic Plaques

open access: yesAdvanced Science, EarlyView.
Aminoferrocene is employed to modify black phosphorus, generating stable phosphorus radicals (FcP). The FcP is then functionalized with hyaluronic acid (HA) to produce the HA‐FcP radical complex, thereby developing a novel, highly efficient, sensitive, long‐lasting, and low‐heavy‐metal‐content radical contrast agent for targeted imaging of ...
Xiao Huang   +6 more
wiley   +1 more source

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