Results 71 to 80 of about 70,844 (290)
InorganicsThe discovery of regulated cell death (RCD) revolutionized chemotherapy. With caspase-dependent apoptosis initially being thought to be the only form of RCD, many drug development strategies aimed to synthesize compounds that turn on this kind of cell ...
Oscar Claudio-Ares +10 more
doaj +1 more source
Cleavage of the Pt-I bond in a Primary Cycloplatinated Amine by Chelation
Crystals, 2015 In the square-planar cycloplatinated complex of R–phenylethylamine, both additional substituents, an anionic iodo and a neutral donor ligand, have been replaced by chelating ethylenediamine.
William Raven +2 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.We characterized the distribution of cargo proteins associated with extracellular vesicles using various exogenous loading methods. In all cases, single‐particle analysis revealed that the distribution of protein content per EV is heterogeneous, following an exponential decay function.
Karl Normak +6 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Six stereoisomeric ruthenium‐peptide conjugates were synthesized and characterized, which showed high potential in photoactivated chemotherapy (PACT) and proximity protein labeling. Abstract Amino acid chirality is known to influence the biological properties of peptide‐containing prodrugs.
Liyan Zhang +7 more
wiley +1 more source
Anacardic Acids and Ferric Ion Chelation [PDF]
, 2007 Kazuo Tsujimoto +3 more
openalex +1 more source
Advanced Healthcare Materials, EarlyView.Metallofullerenol Sc3N@C80(OH)18 demonstrates strong radioprotective properties as a scavenger of both short‐ and long‐lived radicals. The study reveals protection of human erythrocytes from γ‐radiation–induced biochemical damage via post‐irradiation removal of primary and secondary reactive oxidants, supported by pulse radiolysis kinetics.
Jacek Grebowski +6 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Injectable POEGMA‐DA hydrogels, dual‐crosslinked via dopamine self‐polymerization and dynamic hydrazone bonds, provide a safer alternative to invasive wound closure methods and toxic bioadhesives. Mimicking skin‐like mechanics, they achieve effective tissue adhesion for acute dermal wounds, supporting improved healing outcomes, including reducing ...
Gurpreet Kaur Randhawa +6 more
wiley +1 more source
Antioxidant and Metal Chelation-Based Therapies in the Treatment of Prion Disease
Antioxidants, 2014 Many neurodegenerative disorders involve the accumulation of multimeric assemblies and amyloid derived from misfolded conformers of constitutively expressed proteins.
Marcus W. Brazier +2 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Protein corona plays a critical role in the biological behavior of nanoparticles. This study investigates the distribution of complement proteins in soft corona and their impact on the macrophage uptake of polymer nanoparticles. It underlines the significance of soft corona investigation for understanding in vivo performance of nanomedicines.
Ying Qiu +8 more
wiley +1 more source
Iron and Alzheimer’s Disease: From Pathogenesis to Therapeutic Implications
Frontiers in Neuroscience, 2018 As people age, iron deposits in different areas of the brain may impair normal cognitive function and behavior. Abnormal iron metabolism generates hydroxyl radicals through the Fenton reaction, triggers oxidative stress reactions, damages cell lipids ...
Jun-Lin Liu +5 more
doaj +1 more source