Results 131 to 140 of about 624 (180)

A total synthesis of chelidonine

Tetrahedron Letters, 1980
Abstract Condensation of homophthalic anhydride 3 with the Schiff base 4 is exploited as the key step in a total synthesis of the benzophenanthridine alkaloid (±)-chelidonine (8).
Mark Cushman, T.-C. Choong, Joseph T. Valko, Mary P. Koleck   +3 more
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ChemInform Abstract: TOTAL SYNTHESIS OF (.+‐.)‐CHELIDONINE

Chemischer Informationsdienst, 1981
AbstractAus Piperonal (Ia) entstehen die Imine (Ib) und (Ic).
M. CUSHMAN, T. C. CHOONG, J. T. VALKO, M. P. KOLECK   +3 more
openaire   +1 more source

Cytotoxicity and apoptotic signalling cascade induced by chelidonine-loaded PLGA nanoparticles in HepG2 cells in vitro and bioavailability of nano-chelidonine in mice in vivo

Toxicology Letters, 2013
Poor oral bioavailability of chelidonine, a bio-active ingredient of Chelidonium majus, showing anti-cancer potentials against cancer cells with multidrug resistance, makes its optimal use rather limited. To address this problem, we encapsulated chelidonine in biodegradable poly(lactide-co-glycolide) (PLGA) polymers and evaluated nano-chelidonine's ...
Asmita Samadder, Anisur Khuda-Bukhsh, Avijit Paul   +2 more
exaly   +3 more sources

Modulation of multidrug resistance in cancer cells by chelidonine and Chelidonium majus alkaloids

Phytomedicine, 2013
Cancer cells often develop multidrug resistance (MDR) which is a multidimensional problem involving several mechanisms and targets. This study demonstrates that chelidonine and an alkaloid extract from Chelidonium majus, which contains protoberberine and benzo[c]phenanthridine alkaloids, has the ability to overcome MDR of different cancer cell lines ...
Mahmoud Zaki El-Readi, Michael Wink, Mohamed L Ashour   +2 more
exaly   +3 more sources

The Solid‐State and Solution Conformations of (+)‐Chelidonine

Helvetica Chimica Acta, 1990
AbstractThe solid‐state and solution conformations of (+)‐chelidonine (1), a biologically active alkaloid, were determined by X‐ray diffraction and 1H‐NMR spectroscopy, X‐Ray diffraction analysis revealed a conformer with B/C ‘anti‐type’ cis conjunction, a half‐chair of ring B, and a twist half‐chair of ring C.
Miyoko Kamigauchi, Yuko Miyamoto, Kinuko Iwasa, Makiko Sugiura, Zjujiro Nishijo, Narao Takao, Toshimasa Ishida, Yasuko In, Masatoshi Inoue   +8 more
openaire   +1 more source

In vitro and in vivo studies of the metabolic activation of chelidonine

Chemico-Biological Interactions, 2019
Chelidonium majus L. is a herbal medicine widely employed in Europe and Western Asia. Chelidonine (CHE) is a major constituent of the herb and has been reported to be an inhibitor of the cytochrome P450 enzymes (CYP). The major objective of the present study was to study the metabolic pathways of CHE in order to identify potential reactive metabolites ...
Yuyang Liu, Ying Peng, Zhengyu Zhang, Xiucai Guo, Mingshan Ji, Jiang Zheng   +5 more
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ChemInform Abstract: TOTALSYNTHESE VON DL‐CHELIDONIN

Chemischer Informationsdienst. Organische Chemie, 1971
AbstractBei Umsetzung des Na‐Salzes des Urethans (I) mit dem Benzylbromid (II) in Gegenwart von NaJ entsteht das Styrol (IIIa), das durch Bromierung und anschließende Behandlung mit K‐tert.‐butoxid und 1,5‐Diaza‐bicyclo[5 .4.0]undecen‐(5) in Hexamethylphosphorsäureamid in das Acetylen (IIIb) umgewandelt wird.
W. OPPOLZER, K. KELLER
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Mechanism‐based inactivation of cytochrome P450 2D6 by chelidonine

Journal of Biochemical and Molecular Toxicology, 2018
Abstract Chelidonine (CHE) is a major bioactive constituent of greater celandine, a plant used in traditional herbal medicines. CHE has widely been used as an analgesic in clinical settings. We evaluated the inhibitory effects of CHE on human cytochrome P450 enzymes.
Yuyang Liu, Tiantian Cui, Ying Peng, Mingshan Ji, Jiang Zheng   +4 more
openaire   +2 more sources

ChemInform Abstract: Crystal and Molecular Structure of Chelidonine

ChemInform, 1991
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
B. RIBAR, A. KAPOR, C. MEZSAROS, O. GASIC, P. ENGEL   +4 more
openaire   +1 more source

Separation and Determination of the Dissociation Constants of Chelidonine and Protopine by Paper Chromatography

Nature, 1958
IN connexion with the chromatographic separation of alkaloids of Chelidonium maius L.1, I found alkaloids giving rather big spots with a tendency to form tails. This is connected, among other things, with the dissociation constant (K B), the value of which influences the course of the chromatographic process, organic electrolytes having different ...
openaire   +2 more sources