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Safety of a feed additive consisting of Macleaya cordata (Willd.) R. Br. extract and leaves (Sangrovit® Extra) for suckling and weaned piglets and other growing Suidae (Phytobiotics Futterzusatzstoffe GmbH) [PDF]

EFSA Journal
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety of a feed additive consisting of Macleaya cordata (Willd.) R. Br.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba, Marta López‐Alonso, Francesca Marcon, Giovanna Martelli, Carlo Nebbia, Alena Pechová, Miguel Prieto‐Maradona, Katerina Theodoridou, Maria de Lourdes Bastos, Emilio Benfenati, Paul Brantom, Andrew Chesson, Josef Schlatter, Johannes Westendorf, Paola Manini, Birgit Dusemund   +24 more
doaj   +3 more sources

Metabolic engineering of Saccharomyces cerevisiae for chelerythrine biosynthesis [PDF]

Microbial Cell Factories
Background Chelerythrine is an important alkaloid used in agriculture and medicine. However, its structural complexity and low abundance in nature hampers either bulk chemical synthesis or extraction from plants.
Jiawei Zhu, Kai Zhang, Yuanzhi He, Qi Zhang, Yanpeng Ran, Zaigao Tan, Li Cui, Yan Feng   +7 more
doaj   +4 more sources

Chelerythrine-Mediated Growth Inhibition and Resistance Mechanism in Bacillus tropicus [PDF]

Microorganisms
Chelerythrine (CHE) is a naturally occurring benzophenanthridine alkaloid obtained from plants such as Chelidonium majus L. It has received notable attention in pharmacology and microbial control because of its broad-spectrum activity and marked anti ...
Jueyu Wang, Hongxia Wan, Wenqi Chai, Daizong Cui, Min Zhao   +4 more
doaj   +4 more sources

Chelerythrine enhances anti-fungi immunity in Caenorhabditis elegans via DAF-16 and NHR-49 mediated fatty acid metabolism [PDF]

Frontiers in Immunology
Chelerythrine is a natural benzophenanthridine alkaloid with various pharmacological activities. However, whether Chelerythrine can influence innate immunity and its underlying molecular mechanisms remain unclear.
Shenyuan Fan, Guohui Bai, Tingting Zhong, Yi Xiao, Yi Xiao, Yi Xiao, Yuan Tian   +6 more
doaj   +2 more sources

Chelerythrine potentiates meropenem activity against NDM-producing carbapenem-resistant Enterobacteriaceae [PDF]

Frontiers in Veterinary Science
IntroductionNDM-driven carbapenem-resistant Enterobacteriaceae (CRE) are spreading globally, posing a serious One Health threat that extends to veterinary medicine through transmission among food-producing animals, companion animals, and the farm-to-food
Tengfei Li, Yanhu Huang, Wei Liu, Genxi Zhang, Zhiqiang Wang, Zhiqiang Wang, Zhiqiang Wang, Xia Xiao, Xia Xiao, Xia Xiao   +9 more
doaj   +2 more sources

Characterization of calcium sources and downstream signaling pathways following electrical field stimulation of rodent longitudinal esophageal muscle [PDF]

Frontiers in Physiology
AimsTo explore the mechanisms involved in esophageal body longitudinal muscle contraction induced by electrical field stimulation.MethodsIsometric contractions of esophageal segments from wistar rats in an organ bath were induced by electrical field ...
Michelle Gräfe, Julius-Neven Kriese, Timo Kirschstein, Timo Kirschstein, Rüdiger Köhling, Rüdiger Köhling, Felix Bock, Felix Schulze, Felix Schulze, Guido Hildebrandt, Bernd Frerker, Bernd Frerker   +11 more
doaj   +2 more sources

Antibacterial Effect and Mechanism of Chelerythrine on Xanthomonas oryzae pv. oryzae [PDF]

Microorganisms
Xanthomonas oryzae pv. oryzae (Xoo) is a biotrophic bacterial pathogen, which causes devastating bacterial blight disease worldwide. In this study, we thoroughly investigated the antimicrobial effect of the plant-derived extract chelerythrine against ...
Yi Yan, Jueyu Wang, Na Zhao, Daizong Cui, Min Zhao   +4 more
doaj   +2 more sources

Biotechnological Advances in Sanguinarine and Chelerythrine Production from Plume Poppy (Macleaya cordata): A Gene Editing Perspective [PDF]

Plants
Plume poppy (Macleaya cordata), an important member of the Papaveraceae family, is a substantial source of benzylisoquinoline alkaloids (BIAs) such as sanguinarine and chelerythrine.
Bilal A. Rather, Wujun Xu, Aadil Yousuf Tantray, Moksh Mahajan, Huapeng Sun, Hanqing Cong, Xuefei Jiang, M. Iqbal R. Khan, Fei Qiao   +8 more
doaj   +2 more sources

Evaluating Chelerythrine Chloride as a Potential Treatment for Multidrug-Resistant Gonorrhea [PDF]

Infection and Drug Resistance
Ran Zhang,1,2,* Yuqiu Qi,2,* Hui Peng,2,* Chenlong Tao,2,3 Songwei Lu,2 Qiankun Ke,2 Shangzhu Shen,2 Zhuo Wang,1,2 Xiaomian Lin1,2,4 1Department of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, People’s Republic ...
Zhang R, Qi Y, Peng H, Tao C, Lu S, Ke Q, Shen S, Wang Z, Lin X   +8 more
doaj   +2 more sources

Chelerythrine Inhibits TGF-β-Induced Epithelial–Mesenchymal Transition in A549 Cells via RRM2 [PDF]

Pharmaceuticals
Background: The mechanisms underlying the metastasis of non-small-cell lung cancer (NSCLC) have long been a focal point of medical research. The anti-tumor effects of chelerythrine (CHE) have been confirmed; however, its ability to inhibit tumor ...
Jinlong Liu, Mengran Xu, Liu Han, Yuxuan Rao, Haoming Han, Haoran Zheng, Jinying Wu, Xin Sun   +7 more
doaj   +2 more sources