Results 21 to 30 of about 9,197 (244)

Extraction of chelerythrine and its effects on pathogenic fungus spore germination

Pharmacognosy Magazine, 2017
Chemical fungicides are widely used to control crop diseases, but these chemicals have adverse effects. They destroy the ecological environment and even have toxic effects on human beings. In this context, the development of botanical pesticides is relevant.
Wei, Qinghui, Zhao, Min, Li, Xiaoyan
openaire   +4 more sources

Screening and Genomic Analysis of Alkaloid-Producing Endophytic Fungus Fusarium solani Strain MC503 from Macleaya cordata [PDF]

Microorganisms
The extensive harvesting of Macleaya cordata, as a biomedicinal plant and a wild source of quaternary benzo[c]phenanthridine alkaloids, has led to a rapid decline in its population.
Xinhong Wu, Nazidi Ibrahim, Yili Liang, Xueduan Liu   +3 more
doaj   +2 more sources

Inhibitors Targeting Multiple Janus Kinases From Zanthoxylum simulans Mediate Inhibition and Apoptosis Against Gastric Cancer Cells via the Estrogen Pathway

Frontiers in Chemistry, 2022
Janus kinases (JAKs) play a key role in subtly regulating proliferation, apoptosis, and differentiation of cancer cells, and their inhibitors are actively sought as new drug leads.
Yong-Qiang Tian, Yong-Qiang Tian, Dai Hu, Yong-Li Zhang, Yong-Li Zhang, Yong-Li Zhang, Jian Zou, Gui-Lin Chen, Gui-Lin Chen, Gui-Lin Chen, Ming-Quan Guo, Ming-Quan Guo, Ming-Quan Guo   +12 more
doaj   +1 more source

Using Liposomes to Alleviate the Toxicity of Chelerythrine, a Natural PKC Inhibitor, in Treating Non-Small Cell Lung Cancer

Frontiers in Oncology, 2021
Aim of the StudyCHE can inhibit the proliferation of lung cancer cells and induce apoptosis. However, despite having in vivo toxicity, CHE has not been thoroughly investigated in term of its in vivo antitumor effect.
Jiahui Wang, Jiahui Wang, Yijie Song, Yijie Song, Ning Zhang, Ning Li, Congying Liu, Bing Wang, Bing Wang   +8 more
doaj   +1 more source

Identification of Chelerythrine as an Inhibitor of BclXL Function [PDF]

Journal of Biological Chemistry, 2003
The identification of small molecule inhibitors of antiapoptotic Bcl-2 family members has opened up new therapeutic opportunities, while the vast diversity of chemical structures and biological activities of natural products are yet to be systematically exploited.
Chan, Shing-Leng, Lee, Mei Chin, Tan, Kuan Onn, Yang, Lay-Kien, Lee, Alex S. Y., Flotow, Horst, Fu, Nai Yang, Butler, Mark S., Soejarto, Doel D., Buss, Antony D., Yu, Victor C.   +10 more
openaire   +4 more sources

Sanguinarine-Chelerythrine Fraction of Coptis chinensis Exerts Anti-inflammatory Activity in Carrageenan Paw Oedema Test in Rats and Reveals Reduced Gastrotoxicity

Oxidative Medicine and Cellular Longevity, 2022
Inflammatory diseases are a common therapeutic problem and nonsteroidal anti‐inflammatory drugs are not deprived of side effects, of which ulcerogenic activity is one of the most frequent.
Maciej Danielewski, S. Zielińska, A. Matuszewska, W. Słupski, Maciej Włodarczyk, Izabela Jęśkowiak, B. Wiatrak, K. Kowalski, A. Jezierska-Domaradzka, P. Ziólkowski, A. Szeląg, B. Nowak   +11 more
semanticscholar   +1 more source

Protein kinase C-dependent signaling controls the midgut epithelial barrier to malaria parasite infection in anopheline mosquitoes. [PDF]

, 2013
Anopheline mosquitoes are the primary vectors of parasites in the genus Plasmodium, the causative agents of malaria. Malaria parasites undergo a series of complex transformations upon ingestion by the mosquito host.
Camp, Lauren, Luckhart, Shirley, Nadler, Steven A, Pakpour, Nazzy, Smithers, Hannah M, Tu, Zhijian, Wang, Bo   +6 more
core   +6 more sources

Fluorescence, Absorption, Chromatography and Structural Transformation of Chelerythrine and Ethoxychelerythrine in Protic Solvents: A Comparative Study

Molecules, 2022
Chelerythrine (CH) and ethoxychelerythrine (ECH) are chemical reference substances for quality control of Chinese herbal medicines, and ECH is the dihydrogen derivative of CH.
Jinjin Cao, Yanhui Zheng, Ting Liu, Jiamiao Liu, Jinze Liu, Jing Wang, Qirui Sun, Wenhong Li, Yongju Wei   +8 more
doaj   +1 more source

Chelerythrine Chloride: A Potential Rumen Microbial Urease Inhibitor Screened by Targeting UreG

International Journal of Molecular Sciences, 2021
Inhibition of ruminal microbial urease is of particular interest due to its crucial role in regulating urea-N utilization efficiency and nitrogen pollution in the livestock industry. Acetohydroxamic acid (AHA) is currently the only commercially available
Xiaoyin Zhang, Yue He, Zhanbo Xiong, Min Li, Ming Li, N. Zheng, Shengguo Zhao, Jiaqi Wang   +7 more
semanticscholar   +1 more source

Antitumor Effects of Chelerythrine: A Literature Review

Natural Product Communications, 2022
Chelerythrine (CHE), one of the main active components of the medicinal plant, Chelidonium majus, (Figure 1) Botanical authority is traditionally used as a natural medicine for its significant antitumor activity. The relevant literature on the antitumor activity of CHE has been reviewed to provide a theoretical basis for further study and utilization.
Kai Kang, Hanbing Jiang, Shujun Zhang, Binglin Cheng   +3 more
openaire   +1 more source