Results 31 to 40 of about 9,197 (244)

Reinstatement of long-term memory following erasure of its behavioral and synaptic expression in Aplysia. [PDF]

, 2014
Long-term memory (LTM) is believed to be stored in the brain as changes in synaptic connections. Here, we show that LTM storage and synaptic change can be dissociated.
Cai, Diancai, Chen, Shanping, Glanzman, David L, Pearce, Kaycey, Roberts, Adam C, Sun, Philip Y-W   +5 more
core   +2 more sources

Constitutive cytoplasmic localization of p21Waf1/Cip1 affects the apoptotic process in monocytic leukaemia [PDF]

, 2003
In the present study, we analysed the expression and localization of p21Waf1/Cip1 in normal and malignant haematopoietic cells. We demonstrate that in normal monocytic cells, protein kinase C (PKC)-induced p21 gene activation, which is nuclear factor-κB (
A de Thonel, A Rambaldi, A Suzuki, A Suzuki, A Suzuki, A Suzuki, AS Baldwin Jr, CD Bloomfield, D Toullec, E Kobayashi, E Schreiber, H Ichijo, HY Chang, J Chen, J Chen, J Lin, JE Thompson, JJ Schuringa, JM Bennett, JM Herbert, JM Lai, K Kuno, K Kuno, KN Pennington, KU Birkenkamp, KU Birkenkamp, KU Birkenkamp, L Koenderman, L Rossig, LM Tuyt, M Asada, M Asada, M Mizuki, M Nakanishi, ML Guzman, MT Scott, MV Blagosklonny, MW Mayo, PJ Fialkow, RA Steinman, TS Finco, Y Arvidsson, Y Li, Y Luo, Y Miyazaki   +44 more
core   +7 more sources

Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis. [PDF]

, 2015
The loss of photoreceptors is the defining characteristic of many retinal degenerative diseases, but the mechanisms that regulate photoreceptor cell death are not fully understood.
Francesca Cordeiro, M, Guo, L, Moss, SE, Shi, H, Stampoulis, D, Williams, JA   +5 more
core   +1 more source

EFFECTS OF SANGUINARINE AND CHELERYTHRINE ON THE CELL CYCLE AND APOPTOSIS [PDF]

Biomedical Papers, 2006
This review summarizes the involvement of sanguinarine and chelerythrine in cell cycle regulation and cell death in various cell lines. It is focused on their potential in the treatment of cancer.We conducted a search of PubMed, ScienceDirect and Medline for papers on the molecular mechanisms of the biological activity of sanguinarine and chelerythrine
Jana, Malikova, Adela, Zdarilova, Alice, Hlobilkova   +2 more
openaire   +2 more sources

Chelerythrine-Induced Apoptotic Cell Death in HepG2 Cells Involves the Inhibition of Akt Pathway and the Activation of Oxidative Stress and Mitochondrial Apoptotic Pathway

Antioxidants, 2022
Chelerythrine (CHE) is a majorly harmful isoquinoline alkaloid ingredient in Chelidonium majus that could trigger potential hepatotoxicity, but the pivotal molecular mechanisms remain largely unknown.
Yanling Lin, Qinzhi Zhang, Baofu Xie, Haiyang Jiang, Jianzhong Shen, Shusheng Tang, Chongshan Dai   +6 more
doaj   +1 more source

PKM and the maintenance of memory. [PDF]

, 2013
How can memories outlast the molecules from which they are made? Answers to this fundamental question have been slow coming but are now emerging.
Glanzman, David L
core   +1 more source

Protein Kinase C Regulates Expression and Function of the Cav3.2 T-Type Ca²⁺ Channel during Maturation of Neonatal Rat Cardiomyocyte

Membranes, 2022
Two distinct isoforms of the T-type Ca2+ channel, Cav3.1 and Cav3.2, play a pivotal role in the generation of pacemaker potentials in nodal cells in the heart, although the isoform switches from Cav3.2 to Cav3.1 during the early neonatal period with an ...
Yan Wang, Masaki Morishima, Katsushige Ono   +2 more
doaj   +1 more source

Cooperative Glutamatergic and Cholinergic Mechanisms Generate Short-Term Modifications of Synaptic Effectiveness in Prepositus Hypoglossi Neurons [PDF]

, 2005
To maintain horizontal eye position on a visual target after a saccade, extraocular motoneurons need a persistent (tonic) neural activity, called "eye-position signal," generated by prepositus hypoglossi (PH) neurons.
Delgado-Garcia, JM, Navarro Lopez, JDD, Yajeya, J   +2 more
core   +1 more source

Chelerythrine Ameliorates Acetic Acid-Induced Ulcerative Colitis via Suppression of Inflammation and Oxidation

Natural Product Communications, 2022
The incidence of ulcerative colitis (UC), an inflammatory bowel disease (IBD), is drastically increasing globally, leading to greater economic hardship and patient morbidity.
Jun-Song Wu, He-Jing Liu, Si-Jie Han, Ning-Feng Mao, Xue-Feng Liu   +4 more
doaj   +1 more source

Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids [PDF]

, 2003
Copyright © 2003 Elsevier Ireland Ltd. All rights reserved.The alkaloids from Chelidonium majus L. which had a significant inhibitory effect in mitochondrial respiration were those which contain a positive charge due to a quaternary nitrogen atom, i.e ...
Arrabaça, João Daniel, Barreto, Maria do Carmo, Pavão, Maria Leonor, Pinto, Ruy Eugénio   +3 more
core   +1 more source