Results 31 to 40 of about 3,120 (165)
Effect of chelerythrine on mitochondrial energy coupling
FEBS Letters, 1972 Chelerythrine is a 1:2-benzo-phenanthridine alkaloid found in Papaveraceae and Rutaceae [ 1,2] . It is a powerful fungicide [l] and might be responsible, together with related alkaloids, for endemic glaucoma [31. In a study of the effect of several alkaloids on yeast metabolism, chelerythrine was found to be one of the stronger inhibitors of yeast ...
Vallejos, Rubén H., Rizzotto, Marta G.
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Membranes, 2022 Two distinct isoforms of the T-type Ca2+ channel, Cav3.1 and Cav3.2, play a pivotal role in the generation of pacemaker potentials in nodal cells in the heart, although the isoform switches from Cav3.2 to Cav3.1 during the early neonatal period with an ...
Yan Wang +2 more
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Natural Product Communications, 2022 The incidence of ulcerative colitis (UC), an inflammatory bowel disease (IBD), is drastically increasing globally, leading to greater economic hardship and patient morbidity.
Jun-Song Wu +4 more
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Scientific Reports, 2017 Triple-negative breast cancer (TNBC) is a subtype of breast cancer lacking targeted therapy currently. Recent studies imply that protein kinase C may play important roles in TNBC development and could be a specific target. In this study, we evaluated the
Wanjun Lin +5 more
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Molecules, 2013 The title compounds are a class of structurally simple analogues of quaternary benzo[c]phenanthridine alkaloids (QBAs). In order to develop novel QBA-like antifungal drugs, in this study, 24 of the title compounds with various substituents on the N ...
Xin-Juan Yang +6 more
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Toxins, 2010 The bacteria Edwardsiella ictaluri and Flavobacterium columnare cause enteric septicemia and columnaris disease, respectively, in channel catfish (Ictalurus punctatus).
Kevin K. Schrader
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Synthesis and biological evaluation of Argemone mexicana-inspired antimicrobials
Beilstein Journal of Organic Chemistry, 2023 Due to the lack of new antimicrobial drug discovery in recent years and an ever-growing prevalence of multidrug-resistant “superbugs”, there is a pressing need to explore alternative ways to combat pathogenic bacterial and fungal infections.
Jessica Villegas +8 more
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THE PHARMACOLOGICAL EFFICACY OF THE EXTEMPORANEOUS GEL DIAVENOL [PDF]
Annals of Mechnikov's Institute, 2017 Introduction. Diavenol - new extemporaneous gel for the treatment of venous ulcers. The gel contains a synergistic combination C. majus quinolizidine alkaloids and riboflavin. Activate tissue regeneration shown previously for riboflavin, and сheleretrin /
Martynov AV +13 more
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Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors [PDF]
Biochemical and Biophysical Research Communications, 2013 Glutaminase catalyzes the hydrolysis of glutamine to glutamate and plays a central role in the proliferation of neoplastic cells via glutaminolysis, as well as in the generation of excitotoxic glutamate in central nervous system disorders such as HIV-associated dementia (HAD) and multiple sclerosis.
Ajit G, Thomas +9 more
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