Results 11 to 20 of about 9,197 (244)

Antibacterial activity and mechanism of chelerythrine against Streptococcus agalactiae

Frontiers in Veterinary Science
Streptococcus agalactiae (S.agalactiae), also known as group B Streptococcus (GBS), is a highly infectious pathogen. Prolonged antibiotic usage leads to significant issues of antibiotic residue and resistance. Chelerythrine (CHE) is a naturally occurring
Jige Xin, Qiqi Pu, Ruiying Wang, Yeqing Gu, Lin He, Xuan Du, Guowen Tang, Diangang Han   +7 more
exaly   +6 more sources

Benzophenanthridine Alkaloid Chelerythrine Elicits Necroptosis of Gastric Cancer Cells via Selective Conjugation at the Redox Hyperreactive C-Terminal Sec⁴⁹⁸ Residue of Cytosolic Selenoprotein Thioredoxin Reductase

Molecules, 2023
Targeting thioredoxin reductase (TXNRD) with low-weight molecules is emerging as a high-efficacy anti-cancer strategy in chemotherapy. Sanguinarine has been reported to inhibit the activity of TXNRD1, indicating that benzophenanthridine alkaloid is a ...
Minghui Liu, Shibo Sun, Yao Meng, Ling Wang, Haowen Liu, Wuyang Shi, Qiuyu Zhang, Weiping Xu, Bingbing Sun, Jianqiang Xu   +9 more
doaj   +2 more sources

In vitro Anti-Inflammatory Potency of Sanguinarine and Chelerythrine via Interaction with Glucocorticoid Receptor

eFood, 2021
As quaternary benzo[c]phenanthridine alkaloids, sanguinarine and chelerythrine possess multiple biological activities including anti-inflammatory effects.
Jie Zhang, Yuan Liang, Li Ren, Tiehua Zhang   +3 more
doaj   +2 more sources

Antibacterial mechanism of chelerythrine isolated from root of Toddalia asiatica (Linn) Lam

BMC Complementary and Alternative Medicine, 2018
Background Antimicrobial resistance was one of serious worldwide problems confused many researchers. To solve this problem, we explored the antibacterial effect of chelerythrine, a natural compound from traditional Chinese medicine and studied its action.
Nan He, Peiqing Wang, Pengyu Wang, Changyang Ma, Wenyi Kang   +4 more
doaj   +2 more sources

Chelerythrine Chloride Downregulates β-Catenin and Inhibits Stem Cell Properties of Non-Small Cell Lung Carcinoma

Molecules, 2020
Plant secondary metabolites have been seen as alternatives to seeking new medicines for treating various diseases. Phytochemical scientists remain hopeful that compounds isolated from natural sources could help alleviate the leading problem in oncology ...
Win Sen Heng, Shiau-Chuen Cheah
doaj   +2 more sources

Efficacy of Chelerythrine Against Mono- and Dual-Species Biofilms of Candida albicans and Staphylococcus aureus and Its Properties of Inducing Hypha-to-Yeast Transition of C. albicans

Journal of Fungi, 2020
Candida albicans and Staphylococcus aureus specifically often resulted in biofilm-associated diseases, ranging from superficial mucosal to life-threatening systemic infections. Recent studies reported that chelerythrine displayed antimicrobial activities
Weidong Qian, Jianing Zhang, Wenjing Wang, Miao Liu, Yuting Fu, Xiang Li, Ting Wang, Yongdong Li   +7 more
doaj   +2 more sources

Rediscovery of Traditional Plant Medicine: An Underestimated Anticancer Drug of Chelerythrine

Frontiers in Pharmacology, 2022
In many studies, the extensive and significant anticancer activity of chelerythrine (CHE) was identified, which is the primary natural active compound in four traditional botanical drugs and can be applied as a promising treatment in various solid tumors.
Nianzhi Chen, Yulin Qi, Xiao Ma, Xiaolin Xiao, Qingsong Liu, Ting Xia, Juyi Xiang, Jinhao Zeng, Jianyuan Tang   +8 more
doaj   +2 more sources

Protein kinase C inhibitor chelerythrine selectively inhibits proliferation of triple-negative breast cancer cells

Scientific Reports, 2017
Triple-negative breast cancer (TNBC) is a subtype of breast cancer lacking targeted therapy currently. Recent studies imply that protein kinase C may play important roles in TNBC development and could be a specific target. In this study, we evaluated the
Wanjun Lin, Jiajun Huang, Zhongwen Yuan, Senling Feng, Ying Xie, Wenzhe Ma   +5 more
doaj   +2 more sources

Dual Effects of Feed-Additive-Derived Chelerythrine in Combating Mobile Colistin Resistance

Engineering, 2023
The emergence and spread of the mobile colistin-resistance gene, mcr-1, and its variants pose a challenge to the use of colistin, a last-resort antibiotic used to treat severe infections caused by extensively drug-resistant (XDR) Gram-negative pathogens.
Huangwei Song, Xueyang Wang, Muchen Zhang, Zhiyu Zou, Siyuan Yang, Tian Yi, Jianfeng Wang, Dejun Liu, Yingbo Shen, Chongshan Dai, Zhihai Liu, Timothy R. Walsh, Jianzhong Shen, Congming Wu, Yang Wang   +14 more
doaj   +2 more sources

Chelerythrine Attenuates the Inflammation of Lipopolysaccharide-Induced Acute Lung Inflammation Through NF-κB Signaling Pathway Mediated by Nrf2

Frontiers in Pharmacology, 2018
Chelerythrine (CH), is a kind of benzo[c] phenanthridine alkaloid isolated from plants such as Chelidonium, with pharmacological activities as antitumor, antibiosis and anti-inflammation.
Lu Fan, Ye Fan, Li Liu, Weiwei Tao, Xin Shan, Yu Dong, Lin Li, Sen Zhang, Hanqing Wang, Hanqing Wang   +9 more
doaj   +2 more sources