Results 11 to 20 of about 3,120 (165)

Antibacterial activity and mechanism of chelerythrine against Streptococcus agalactiae

Frontiers in Veterinary Science
Streptococcus agalactiae (S.agalactiae), also known as group B Streptococcus (GBS), is a highly infectious pathogen. Prolonged antibiotic usage leads to significant issues of antibiotic residue and resistance. Chelerythrine (CHE) is a naturally occurring
Jige Xin, Qiqi Pu, Ruiying Wang, Yeqing Gu, Lin He, Xuan Du, Guowen Tang, Diangang Han   +7 more
exaly   +5 more sources

Sanguinarine–Chelerythrine from Coptis chinensis Offers Analgesic and Anti-Inflammatory Effects Without Gastrotoxicity [PDF]

Pharmaceutics
Background: Pain is a major clinical and socioeconomic problem worldwide. The available therapies are not always effective and are often associated with the multiple adverse effects that reduce their clinical application.
Maciej Danielewski, Sylwia Zielińska, Anna Merwid-Ląd, Marta Szandruk-Bender, Wojciech Słupski, Maciej Włodarczyk, Tomasz Sozański, Piotr Ziółkowski, Adam Szeląg, Beata Nowak   +9 more
doaj   +2 more sources

Chelerythrine Protects Against Acetaminophen-Induced Acute Liver Injury: Insights from Gut Microbiota and Multi-Omics Analysis [PDF]

Antioxidants
Chelerythrine (CHE) is the main active component of Chelidonium majus L., possessing excellent antioxidant and anti-inflammatory properties. However, the protective effects of CHE against liver injury and its underlying mechanisms remain unclear.
Jinlong Liu, Yanfei Zhang, Hao Wu, Pan Yang, Wenlong Wang, Chenliang Li, Hong Cao, Jinying Wu, Xin Sun   +8 more
doaj   +2 more sources

In Vitro Antifungal Activity of Sanguinarine and Chelerythrine Derivatives against Phytopathogenic Fungi

Molecules, 2012
In order to understand the antifungal activity of some derivatives of sanguinarine (S) and chelerythrine (C) and their structure-activity relationships, sixteen derivatives of S and C were prepared and evaluated for in vitro antifungal activity against ...
Le Zhou
exaly   +3 more sources

Rediscovery of Traditional Plant Medicine: An Underestimated Anticancer Drug of Chelerythrine

Frontiers in Pharmacology, 2022
In many studies, the extensive and significant anticancer activity of chelerythrine (CHE) was identified, which is the primary natural active compound in four traditional botanical drugs and can be applied as a promising treatment in various solid tumors.
Nianzhi Chen, Yulin Qi, Xiao Ma, Xiaolin Xiao, Qingsong Liu, Ting Xia, Juyi Xiang, Jinhao Zeng, Jianyuan Tang   +8 more
doaj   +3 more sources

Metabolism and Tissue Distribution of Chelerythrine and Effects of Macleaya Cordata Extracts on Liver NAD(P)H Quinone Oxidoreductase

Frontiers in Veterinary Science, 2021
Background:Macleaya cordata (Willd.) (Papaveraceae) is listed as a feed additive in animal production by the European Food Authority.Methods: The metabolites of chelerythrine in rats were measured in vitro and in vivo by rapid and accurate high ...
Chong-Yin Huang, Chong-Yin Huang, Ya-Jun Huang, Ya-Jun Huang, Zhuo-Yi Zhang, Zhuo-Yi Zhang, Yi-Song Liu, Zhao-Ying Liu, Zhao-Ying Liu   +8 more
doaj   +1 more source

Benzophenanthridine Alkaloid Chelerythrine Elicits Necroptosis of Gastric Cancer Cells via Selective Conjugation at the Redox Hyperreactive C-Terminal Sec⁴⁹⁸ Residue of Cytosolic Selenoprotein Thioredoxin Reductase

Molecules, 2023
Targeting thioredoxin reductase (TXNRD) with low-weight molecules is emerging as a high-efficacy anti-cancer strategy in chemotherapy. Sanguinarine has been reported to inhibit the activity of TXNRD1, indicating that benzophenanthridine alkaloid is a ...
Minghui Liu, Shibo Sun, Yao Meng, Ling Wang, Haowen Liu, Wuyang Shi, Qiuyu Zhang, Weiping Xu, Bingbing Sun, Jianqiang Xu   +9 more
doaj   +1 more source

In vitro Anti-Inflammatory Potency of Sanguinarine and Chelerythrine via Interaction with Glucocorticoid Receptor

eFood, 2021
As quaternary benzo[c]phenanthridine alkaloids, sanguinarine and chelerythrine possess multiple biological activities including anti-inflammatory effects.
Jie Zhang, Yuan Liang, Li Ren, Tiehua Zhang   +3 more
doaj   +1 more source

Inhibitors Targeting Multiple Janus Kinases From Zanthoxylum simulans Mediate Inhibition and Apoptosis Against Gastric Cancer Cells via the Estrogen Pathway

Frontiers in Chemistry, 2022
Janus kinases (JAKs) play a key role in subtly regulating proliferation, apoptosis, and differentiation of cancer cells, and their inhibitors are actively sought as new drug leads.
Yong-Qiang Tian, Yong-Qiang Tian, Dai Hu, Yong-Li Zhang, Yong-Li Zhang, Yong-Li Zhang, Jian Zou, Gui-Lin Chen, Gui-Lin Chen, Gui-Lin Chen, Ming-Quan Guo, Ming-Quan Guo, Ming-Quan Guo   +12 more
doaj   +1 more source

Identification of Chelerythrine as an Inhibitor of BclXL Function [PDF]

Journal of Biological Chemistry, 2003
The identification of small molecule inhibitors of antiapoptotic Bcl-2 family members has opened up new therapeutic opportunities, while the vast diversity of chemical structures and biological activities of natural products are yet to be systematically exploited.
Chan, Shing-Leng, Lee, Mei Chin, Tan, Kuan Onn, Yang, Lay-Kien, Lee, Alex S. Y., Flotow, Horst, Fu, Nai Yang, Butler, Mark S., Soejarto, Doel D., Buss, Antony D., Yu, Victor C.   +10 more
openaire   +5 more sources