Integrating bioinformatics and experimental models to investigate the mechanism of the chelidonine-induced mitotic catastrophe via the AKT/FOXO3/FOXM1 axis in breast cancer cells [PDF]
Biomolecules & Biomedicine, 2023 Breast cancer (BC) is currently the most frequent and lethal cancer among women, and therefore, identification of novel biomarkers and potential anticancer agents for BC is crucial.
Huimin Li +4 more
doaj +5 more sources
The Cultivation of Chelidonium majus L. Increased the Total Alkaloid Content and Cytotoxic Activity Compared with Those of Wild-Grown Plants [PDF]
Plants, 2021 The effect of cultivation practises on both the phytochemical profile and biological activity of aqueous ethanol extracts of Chelidonium majus L. was studied. Extracts were prepared from aerial parts of the same plant population collected in the wild and
Valerija Krizhanovska +7 more
doaj +5 more sources
The in vivo effect of chelidonine on the stem cell system of planarians [PDF]
European Journal of Pharmacology, 2012 The presence of adult pluripotent stem cells and the amazing regenerative capabilities make planarian flatworms an extraordinary experimental model to assess in vivo the effects of substances of both natural and synthetic origin on stem cell ...
Paolo Deri +2 more
exaly +6 more sources
Identification of potential bioactive phytochemicals for the inhibition of platelet-derived growth factor receptor β: a structure-based approach for cancer therapy [PDF]
Frontiers in Molecular BiosciencesPlatelet-derived growth factor receptor beta (PDGFRβ) belongs to the receptor tyrosine kinase (RTK) protein family and is implicated in several disorders such as hematopoietic, glial, and soft-tissue cancer, non-cancerous disorders, including skeletal ...
Insan Habib +8 more
doaj +5 more sources
Chelidonine reduces IL-1β-induced inflammation and matrix catabolism in chondrocytes and attenuates cartilage degeneration and synovial inflammation in rats [PDF]
Brazilian Journal of Medical and Biological Research, 2023 Chondrocyte inflammation and catabolism are two major features in the progression of osteoarthritis (OA). Chelidonine, a principal alkaloid extracted from Chelidonium majus, is suggested to show anti-inflammation, anti-apoptosis, and anti-oxidation ...
Mao Li +6 more
doaj +2 more sources
Chelidonine Induces Apoptosis via GADD45a-p53 Regulation in Human Pancreatic Cancer Cells
Integrative Cancer Therapies, 2021 Chelidonium majus has been used as a traditional medicine in China and western countries for various diseases, including inflammation and cancer. However, the anti-cancer effect of chelidonine, a major compound of C.
Sanghun Lee, Hyuno Kang
exaly +2 more sources
The Synergistic Mechanism of Chelidonium majus Alkaloids on Melanoma Treatment via a Multi-Strategy Insight [PDF]
MoleculesMelanoma represents a formidable challenge in dermatological oncology due to its resistance to conventional treatments. The Celandine Alkali Injection Formula (CAIF) offers benefits on clinical internal medicine treatments, within which chelidonine and ...
Peng Chen +4 more
doaj +2 more sources
Identification of Effective Anticancer G-Quadruplex-Targeting Chemotypes through the Exploration of a High Diversity Library of Natural Compounds [PDF]
Pharmaceutics, 2021 In the quest for selective G-quadruplex (G4)-targeting chemotypes, natural compounds have been thus far poorly explored, though representing appealing candidates due to the high structural diversity of their scaffolds.
Chiara Platella +12 more
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In vitro wound healing of tumor cells: inhibition of cell migration by selected cytotoxic alkaloids [PDF]
BMC Pharmacology and Toxicology, 2019 Background Cell migration is involved in several pathological processes such as tumor invasion, neoangiogenesis and metastasis. Microtubules are needed in directional migration. Methods To investigate the effects of microtubule-binding agents (paclitaxel,
Xiaojuan Wang +4 more
doaj +3 more sources
Screening Papaveraceae as Novel Antibiofilm Natural-Based Agents [PDF]
Molecules, 2021 The antimicrobial properties of herbs from Papaveraceae have been used in medicine for centuries. Nevertheless, mutual relationships between the individual bioactive substances contained in these plants remain poorly elucidated.
Sylwia Zielińska +13 more
doaj +3 more sources