Chelidonine reduces IL-1β-induced inflammation and matrix catabolism in chondrocytes and attenuates cartilage degeneration and synovial inflammation in rats [PDF]
Brazilian Journal of Medical and Biological Research, 2023 Chondrocyte inflammation and catabolism are two major features in the progression of osteoarthritis (OA). Chelidonine, a principal alkaloid extracted from Chelidonium majus, is suggested to show anti-inflammation, anti-apoptosis, and anti-oxidation ...
Mao Li +6 more
doaj +3 more sources
Integrating bioinformatics and experimental models to investigate the mechanism of the chelidonine-induced mitotic catastrophe via the AKT/FOXO3/FOXM1 axis in breast cancer cells [PDF]
Biomolecules & Biomedicine, 2023 Breast cancer (BC) is currently the most frequent and lethal cancer among women, and therefore, identification of novel biomarkers and potential anticancer agents for BC is crucial.
Huimin Li +4 more
doaj +4 more sources
The Synergistic Mechanism of Chelidonium majus Alkaloids on Melanoma Treatment via a Multi-Strategy Insight [PDF]
MoleculesMelanoma represents a formidable challenge in dermatological oncology due to its resistance to conventional treatments. The Celandine Alkali Injection Formula (CAIF) offers benefits on clinical internal medicine treatments, within which chelidonine and ...
Peng Chen +4 more
doaj +3 more sources
Chelidonine Induces Apoptosis via GADD45a-p53 Regulation in Human Pancreatic Cancer Cells
Integrative Cancer Therapies, 2021 Chelidonium majus has been used as a traditional medicine in China and western countries for various diseases, including inflammation and cancer. However, the anti-cancer effect of chelidonine, a major compound of C.
Hwa-Seung Yoo
exaly +2 more sources
Identification of Effective Anticancer G-Quadruplex-Targeting Chemotypes through the Exploration of a High Diversity Library of Natural Compounds [PDF]
Pharmaceutics, 2021 In the quest for selective G-quadruplex (G4)-targeting chemotypes, natural compounds have been thus far poorly explored, though representing appealing candidates due to the high structural diversity of their scaffolds.
Chiara Platella +12 more
doaj +2 more sources
Effects of endophytic fungus Y118 on physiological and biochemical indexes and quality improvement of Zanthoxylum Nitidum (Roxb.) DC [PDF]
Scientific ReportsTo understand the effects of endophytic fungus Y118 on the physiological characteristics of Zanthoxylum nitidum (Roxb.) DC after co-culture with its host Zanthoxylum nitidum, we measured the plant growth index (dry root weight) of Zanthoxylum nitidum at ...
Zebi Xie +6 more
doaj +2 more sources
Genetic insights into alcohol-associated liver disease: integrative transcriptome-wide analysis identifies novel susceptibility genes [PDF]
Frontiers in MedicineBackgroundAlcohol-associated liver disease (ALD) is a chronic condition influenced by both genetic and environmental factors. While GWAS has identified ALD-related loci (PNPLA3, MBOAT7, TM6SF2), underlying genetic mechanisms and therapeutic targets ...
Qianchang Wang +5 more
doaj +2 more sources
Potential of isoquinoline-alkaloid-rich Papaveraceae extracts against bacteria causing ocular infections – In vitro and In vivo study [PDF]
Frontiers in PharmacologyIntroductionThere is an evident need for novel ophthalmic therapeutics that operate outside the conventional antibiotic and chemically synthetized antiseptic paradigms.
Monika Dzięgielewska +14 more
doaj +2 more sources
Biological Activities of Some Isoquinoline Alkaloids from Fumaria schleicheri Soy. Will. [PDF]
Plants, 2022 Fumaria schleicheri Soy. Will. is a species belonging to the Papaveraceae family, being widespread in East-Central and Southern Europe. As with numerous other species of the genus, it is used in traditional medicine for the treatment of hepatobiliary and
Ramona Păltinean +12 more
doaj +2 more sources
Effect of Soil-Applied Metabolic Modulators on the Accumulation of Specialized Metabolites in Chelidonium majus L. [PDF]
MoleculesVarious metabolic modulators have been widely used in recent years to increase the accumulation of desired secondary metabolites in medicinal plants, although most studies to date have focused on in vitro systems.
Maria Stasińska-Jakubas +5 more
doaj +2 more sources