Results 31 to 40 of about 1,235 (206)
Chelidonine Induces Concurrent Elevation of pSer-STAT3 and Bcl-2 Levels in a Mitotic Subpopulation of Human T-Leukemia/Lymphoma Cells. [PDF]
Int J Mol SciSignal transducer and activator of transcription 3 (STAT3) is a transcription factor that regulates a broad spectrum of genes with oncogenic potential, thereby serving as a critical driver of tumorigenesis.
Baddour S +5 more
europepmc +2 more sources
The Herbal Pair <i>Polygonum hydropiper</i> <i>L-Coptis chinensis Franch</i> Attenuate DSS-Induced Ulcerative Colitis by Modulating Metabolism and Intestinal Flora. [PDF]
Food Sci NutrPH‐CC regulates dysbiosis in intestinal flora and metabolic disorders in UC mice by reducing the abundance of specific bacterial groups, thereby alleviating inflammatory damage to the colonic mucosa and improving the overall condition of UC. ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory bowel disease in which dysbiosis of the intestinal ...
Zhu F +6 more
europepmc +2 more sources
Scientific African, 2023 Triple-negative breast cancer (TNBC) overexpresses poly-ADP ribose-polymerase (PARP), and histone deacetylase (HDAC) specific isoforms, PARP2 and HDAC7 respectively.
Rahmon Kanmodi +3 more
doaj +1 more source
The effect of greater celandine active ingredient chelidonine on isolated rat bladder and trachea smooth muscles and primary lung and kidney cell lines [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2020 This study aims to explore the pharmacodynamics of chelidonine, the active ingredient in greater celandine (Chelidonium majus L.), on in vitro rat bladder and trachea tissue, and evaluate its cell protective effects on primary lung and kidney cell lines.
Emre ARSLANBAŞ +6 more
doaj +1 more source
Anticoronavirus Isoquinoline Alkaloids: Unraveling the Secrets of Their Structure-Activity Relationship. [PDF]
Influenza Other Respir VirusesABSTRACT Background Natural alkaloids are a structurally diverse class of bioactive compounds with significant therapeutic potential. This study aimed to evaluate the in vitro antiviral activity of various natural alkaloids against coronaviruses, clarify molecular effects via bioassays and docking, and explore structure–activity relationships.
Safratova M +11 more
europepmc +2 more sources
ELECTROPHORESIS, Volume 44, Issue 13-14, Page 1114-1142, July 2023., 2023 Abstract The process of choosing the most proper technique for studying the molecular interactions is based on critical factors such as instrumentation complexity, automation, experimental procedures, analysis time, consumables, and cost‐value. This review has tracked the use of affinity capillary electrophoresis (ACE) and microscale thermophoresis ...
Mufarreh Asmari +5 more
wiley +1 more source
Molecules, 2022 The Chelidonium majus plant is rich in biologically active isoquinoline alkaloids. These alkaline polar compounds are isolated from raw materials with the use of acidified water or methanol; next, after alkalisation of the extract, they are extracted ...
Maciej Strzemski +9 more
doaj +1 more source
EFSA Journal, Volume 21, Issue 6, June 2023., 2023 Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of Macleaya cordata (Willd.) R. Br. extract and leaves (Sangrovit® Extra) when used as a zootechnical feed additive (functional group: other zootechnical additives) for all poultry species (excluding laying and breeding ...
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) +23 more
wiley +1 more source
ChemistryOpen, Volume 11, Issue 5, May 2022., 2022 Ligands selectively targeting DNA G‐quadruplexes (G4s) represent valuable targeted anticancer drugs. Aiming at speeding the identification of G4‐targeting ligands, the affinity chromatography‐based assay named G‐quadruplex on Oligo Affinity Support (G4‐OAS) was developed, by synthesizing G4‐forming sequences on commercial polystyrene OAS.
Chiara Platella +4 more
wiley +1 more source
Evidence-Based Complementary and Alternative Medicine, Volume 2021, Issue 1, 2021., 2021 Since its inception, the coronavirus disease 2019 (COVID‐19) pandemic has infected millions of people around the world. Therefore, it is necessary to find effective treatments against Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2), as it is the viral source of COVID‐19.
Mohammad Bagher Majnooni +6 more
wiley +1 more source