Results 31 to 40 of about 624 (180)
ChemistryOpen, Volume 11, Issue 5, May 2022., 2022 Ligands selectively targeting DNA G‐quadruplexes (G4s) represent valuable targeted anticancer drugs. Aiming at speeding the identification of G4‐targeting ligands, the affinity chromatography‐based assay named G‐quadruplex on Oligo Affinity Support (G4‐OAS) was developed, by synthesizing G4‐forming sequences on commercial polystyrene OAS.
Chiara Platella +4 more
wiley +1 more source
Evidence-Based Complementary and Alternative Medicine, Volume 2021, Issue 1, 2021., 2021 Since its inception, the coronavirus disease 2019 (COVID‐19) pandemic has infected millions of people around the world. Therefore, it is necessary to find effective treatments against Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2), as it is the viral source of COVID‐19.
Mohammad Bagher Majnooni +6 more
wiley +1 more source
Anticoronavirus Isoquinoline Alkaloids: Unraveling the Secrets of Their Structure-Activity Relationship. [PDF]
Influenza Other Respir VirusesABSTRACT Background Natural alkaloids are a structurally diverse class of bioactive compounds with significant therapeutic potential. This study aimed to evaluate the in vitro antiviral activity of various natural alkaloids against coronaviruses, clarify molecular effects via bioassays and docking, and explore structure–activity relationships.
Safratova M +11 more
europepmc +2 more sources
THE PHARMACOLOGICAL EFFICACY OF THE EXTEMPORANEOUS GEL DIAVENOL [PDF]
Annals of Mechnikov's Institute, 2017 Introduction. Diavenol - new extemporaneous gel for the treatment of venous ulcers. The gel contains a synergistic combination C. majus quinolizidine alkaloids and riboflavin. Activate tissue regeneration shown previously for riboflavin, and сheleretrin /
Martynov AV +13 more
doaj +1 more source
Nonconventional Techniques in Plant Alkaloid Extraction: A Decade of Progress (2014-2023). [PDF]
Chem BiodiversThis figure seeks to represent the evolution of the different unconventional approaches that were adopted for the extraction of plant‐derived alkaloids during the decade from 2014 to 2023. ABSTRACT Plant metabolism encompasses primary and secondary pathways, with secondary metabolism yielding diverse natural products crucial for plant adaptation and ...
Sipoloni VM +5 more
europepmc +2 more sources
Isolation of Alkaloids from Papaver rhoeas (Papaveraceae) Wildly Grown in Iraq
Iraqi Journal of Pharmaceutical Sciences, 2021 The plant Papaver rhoeas ,which belongs to family Papaveraceae and known as common poppy is wildly grown in Iraq .It was used in traditional medicine in wide range of diseases including inflammation, diarrhea, sleep disorders, treatment of cough ...
Amenah Ayad Lafta, Maha N. Hamad
doaj +1 more source
Plants, 2021 The effect of cultivation practises on both the phytochemical profile and biological activity of aqueous ethanol extracts of Chelidonium majus L. was studied. Extracts were prepared from aerial parts of the same plant population collected in the wild and
Valerija Krizhanovska +7 more
doaj +1 more source
, 2016 Total syntheses of chelidonine and norchelidonine featuring an enamide–benzyne–[2 + 2] cycloaddition initiated cascade is described.
Zhi-Xiong Ma (1334016) +2 more
core +2 more sources
Natural Product Communications, 2017 This study focuses on the comparative in vitro cytotoxicity of chelidonine and homochelidonine on human cancer and non-cancer cells. Both alkaloids produced a decrease in cellular growth in a dose-dependent manner exhibiting greater potency in cancer ...
Radim Havelek +5 more
doaj +1 more source
Crystal and Molecular Structure of Chelidonine [PDF]
, 1990 The crystal and molecular structure of benzophenantridine alkaloid chelidonine, C20H19N05 CM = 353.37) was solved by direct methods and refined by the least-squares technique to a conventional R index of 0.117 for 1888 unique reflections.
Csaba Mezsaros +9 more
core +1 more source