Results 51 to 60 of about 624 (180)

Natural Antispasmodics: Source, Stereochemical Configuration, and Biological Activity

BioMed Research International, Volume 2018, Issue 1, 2018., 2018
Natural products with antispasmodic activity have been used in traditional medicine to alleviate different illnesses since the remote past. We searched the literature and compiled the antispasmodic activity of 248 natural compounds isolated from terrestrial plants.
Edith Fabiola Martínez-Pérez, Zaida N. Juárez, Luis R. Hernández, Horacio Bach, Juergen Buenger   +4 more
wiley   +1 more source

Influence of chelidonine, an inhibitor of tubulin polymerisation on tyrosine kinase activity in normal, transformed and malignant cell lines

, 2004
Chelidonine, a tertiary hexahydro-benzophenanthridine alkaloid is an inhibitor of tubulin polymerisation and has been revealed to arrest cells in G2/M. Since enhanced tyrosine kinase (TK) activity is linked to the transition from normal to the immortal ...
Lottering, Mona-Liza, Joubert, Annie M., Panzer, Annie   +2 more
core   +1 more source

Effect of mobile phase buffer ph on separation selectivity of some isoquinoline alkaloids in reversed-phase systems of Pressurized Planar Electrochromatography and High-Performance Thin-Layer Chromatography

Current Issues in Pharmacy and Medical Sciences, 2013
Separation of some isoquinoline alkaloids (narcotine, chelidonine, dihydrocodeine, cinchonine, berberine, cinchonidine, papaverine, apomorphine) has been investigated with pressurized planar electrochromatography (PPEC) and high-performance thin-layer ...
Ewelina Kopciał, Beata Polak, Rafał Pietraś, Paulina Mączka, Tadeusz H. Dzido   +4 more
doaj   +1 more source

Natural Pesticides in Crop Protection: Comparative Advantages, Ecological Risks, and Future Directions

Journal of Chemistry, Volume 2026, Issue 1, 2026.
Although synthetic pesticides have long been used to protect crops, their widespread use has led to significant health and environmental problems, including ecological contamination, resistant pest populations, and hazardous residues in food. These restrictions have sparked interest in natural pesticides (NPs), particularly the secondary metabolites of
Ruth Mwangi, Njogu M. Kimani, Munmun Bardhan   +2 more
wiley   +1 more source

Systematic Evaluation of Chromatographic Parameters for Isoquinoline Alkaloids on XB‐C18 Core‐Shell Column Using Different Mobile Phase Compositions

Journal of Analytical Methods in Chemistry, Volume 2018, Issue 1, 2018., 2018
Chelidonium majus L. is a rich source of isoquinoline alkaloids with confirmed anti‐inflammatory, choleretic, spasmolytic, antitumor, and antimicrobial activities. However, their chromatographic analysis is difficult because they may exist both in charged and uncharged forms and may result in the irregular peak shape and the decrease in chromatographic
Ireneusz Sowa, Sylwia Zielińska, Jan Sawicki, Anna Bogucka-Kocka, Michał Staniak, Ewa Bartusiak-Szcześniak, Maja Podolska-Fajks, Ryszard Kocjan, Magdalena Wójciak-Kosior, Adam Voelkel   +9 more
wiley   +1 more source

Imaging microtubule dynamics: A new frontier in biomarker development for neurodegenerative diseases

Alzheimer's &Dementia, Volume 21, Issue 9, September 2025.
Abstract Microtubules (MTs) are essential components of the neuronal cytoskeleton, playing key roles in intracellular transport, synaptic function, and overall neuronal integrity. Although MT dynamics and MT‐binding agents have been studied extensively, their potential as biomarkers in neurodegenerative diseases has received limited attention. Emerging
Naresh Damuka, Samuel N. Lockhart, Kiran K. Solingapuram Sai   +2 more
wiley   +1 more source

The Elevation of LC‐ESI‐Q‐TOF‐MS Response in the Analysis of Isoquinoline Alkaloids from Some Papaveraceae and Berberidaceae Representatives

Journal of Analytical Methods in Chemistry, Volume 2017, Issue 1, 2017., 2017
Twenty‐five methanol extracts obtained from various representatives of Papaveraceae and Berberidaceae botanical families (genera: Papaver, Argemone, Eschscholzia, Chelidonium, Glaucium, and Berberis) were screened for their alkaloid content in an optimized method suitable for the LC‐ESI‐Q‐TOF‐MS analysis. Twelve pharmacologically important isoquinoline
Wirginia Kukula-Koch, Antony C. Calokerinos   +1 more
wiley   +1 more source

Apoptotic response of uveal melanoma cells upon treatment with chelidonine, sanguinarine and chelerythrine

, 2006
The benzophenanthridine alkaloids sanguinarine, chelerythrine and chelidonine were reported previously to provoke cell death in a variety of tumor cells suggesting their potential application as anticancer agents.
András Berta, Bodnár, Andrea, Kemény-Beke, Ádám, Andrea Facskó, Beck, Zoltán, Damjanovich, Judit, Berta, András, Ádám Kemény-Beke, János Aradi, Zoltán Beck, Aradi, János, Judit Damjanovich, Andrea Bodnár, Facskó, Andrea   +13 more
core   +1 more source

Intracellular Accumulation as an Indicator of Cytotoxicity to Screen Hepatotoxic Components of Chelidonium majus L. by LC–MS/MS

Molecules, 2019
A novel strategy was developed to identify hepatotoxic compounds in traditional Chinese medicines (TCMs). It is based on the exposure of HL-7702 cells to a TCM extract, followed by the identification and further determination of potential hepatotoxic ...
Cuiting Wu, Xin Wang, Ming Xu, Youping Liu, Xin Di   +4 more
doaj   +1 more source

Highly Stereoselective Total Syntheses of (±)-Chelidonine and of (±)-Norchelidonine by an Intramolecular o-Quinodimethane/Nitrostyrene-Cycloaddition

, 1983
Conversion of 2-bromomethylstyrene 22 and benzocyclobutenyl carbamate 28 to the benzophenanthridine alkaloids (±)-chelidonine (1, five steps, 25% from 28) and to (±)-norchelidonine (2, six steps, 24% from 28) are described.
Von Oppolzer, Wolfgang, Robbiani, Christian   +1 more
core   +1 more source