UPLC-MS/MS Profile of Alkaloids with Cytotoxic Properties of Selected Medicinal Plants of the Berberidaceae [PDF]
Oxidative Medicine and Cellular Longevity, Volume 2017, Issue 1, 2017., 2017 Cancer is one of the most occurring diseases in developed and developing countries. Plant-based compounds are still researched for their anticancer activity and for their quantity in plants.
Anna Bogucka-Kocka +5 more
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Structure-Based Virtual Screening of Potential Inhibitors Targeting the Prolyl-tRNA Synthetase (PRS) in Eimeria tenella: Insights from Molecular Docking, ADMET Studies, and Molecular Dynamics Simulations [PDF]
MoleculesAvian coccidiosis, caused by protozoan parasites of the genus Eimeria, poses a major threat to the poultry industry worldwide, leading to severe economic losses through reduced growth rates, poor feed efficiency, and increased mortality.
Haiming Cai +10 more
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Effect of Soil-Applied Metabolic Modulators on the Accumulation of Specialized Metabolites in Chelidonium majus L. [PDF]
MoleculesVarious metabolic modulators have been widely used in recent years to increase the accumulation of desired secondary metabolites in medicinal plants, although most studies to date have focused on in vitro systems.
Maria Stasińska-Jakubas +5 more
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Identification of Phytochemical-Based β-Catenin Nuclear Localization Inhibitor in NSCLC: Differential Targeting Population from Member of Isothiocyanates [PDF]
Molecules, 2021 Decades of research has convinced us that phytochemical compounds contained within the plant products are the real deal, and they provide benefits such as health maintenance an d cure to illnesses.
Win Sen Heng, Shiau-Chuen Cheah
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Phytochemical study on Berberis sibirica Pall. [PDF]
Mongolian Journal of Chemistry, 2014 From the aerial parts (700g) of berberis sibirica pall. 6 isoquinoline alkaloids of protoberberine, protopine, benzophenantridine and proaporphine type were isolated. The known alkaloids (-)-tetrahydropseudocoptisine, pseudoprotopine, (+)-chelidonine and
A Solongo +4 more
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Unveiling potential diagnostic biomarkers for rheumatoid arthritis through integrated gene expression analysis [PDF]
Frontiers in ImmunologyObjectiveRheumatoid arthritis (RA) is a chronic autoimmune disorder that significantly impacts quality of life. Despite extensive research, its pathogenesis remains unclear.
Zhi-wei Feng +8 more
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Chelidonine enhances the antitumor effect of lenvatinib on hepatocellular carcinoma cells.
OncoTargets and therapy, 2019 Lenvatinib is a newly approved molecular targeted drug for the treatment of advanced hepatocellular carcinoma (HCC). However, the high cost associated with this treatment poses a huge financial burden on patients and the entire public health system.
Hou,Fang-jie +5 more
openaire +4 more sources
Identifying Therapeutic Targets and Potential Drugs for Diabetic Retinopathy: Focus on Oxidative Stress and Immune Infiltration. [PDF]
J Inflamm ResHongsong Peng,1,2,* Qiang Hu,1,2,* Xue Zhang,1,2,* Jiayang Huang,1,2 Shan Luo,1,2 Yiming Zhang,1 Bo Jiang,1 Dawei Sun1 1Department of Ophthalmology, The second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, People’s ...
Peng H +7 more
europepmc +3 more sources
Chelidonine overcomes P-gp-mediated adriamycin resistance in MCF-7/ADR cells by inhibiting PDGFR<i>β</i>/PI3K/Akt pathway. [PDF]
Chin Herb MedObjective Chemoresistance represents a major obstacle in breast cancer (BC) treatment. Chelidonine could prevent various tumor cell types. However, the effect and mechanism of chelidonine against BC chemotherapy resistance have not been elucidated.
Zou X +8 more
europepmc +2 more sources
Chelidonine inhibits melanoma cell malignancy by inactivating TLR4/NF-κB and PI3K/AKT signaling pathways. [PDF]
Korean J Physiol PharmacolMelanoma is a common and aggressive tumor, characterized by a high incidence rate and extensive metastasis. Chelidonine exhibits a broad range of biological properties including anti-inflammatory, antimicrobial, and anticancer effects.
Zhou Y, Han H, Li P, Wei W.
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