Journal of Pure and Applied Microbiology, 2020 Natural compounds represent the great capability to stimulate several cell types. Macrophage plays an important role for an effective immune response for infection and inflammation.
Nuchsupha Sunthamala +7 more
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Telomere shortening in breast cancer cells (MCF7) under treatment with low doses of the benzylisoquinoline alkaloid chelidonine. [PDF]
PLoS ONE, 2018 Telomeres, the specialized dynamic structures at chromosome ends, regularly shrink with every replication. Thus, they function as an internal molecular clock counting down the number of cell divisions. However, most cancer cells escape this limitation by
Sakineh Kazemi Noureini +2 more
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The effect of greater celandine active ingredient chelidonine on isolated rat bladder and trachea smooth muscles and primary lung and kidney cell lines [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2020 This study aims to explore the pharmacodynamics of chelidonine, the active ingredient in greater celandine (Chelidonium majus L.), on in vitro rat bladder and trachea tissue, and evaluate its cell protective effects on primary lung and kidney cell lines.
Emre ARSLANBAŞ +6 more
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Scientific African, 2023 Triple-negative breast cancer (TNBC) overexpresses poly-ADP ribose-polymerase (PARP), and histone deacetylase (HDAC) specific isoforms, PARP2 and HDAC7 respectively.
Rahmon Kanmodi +3 more
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Proapoptotic activity of Ukrain is based on
BMC Cancer, 2006 Background The anticancer drug Ukrain (NSC-631570) which has been specified by the manufacturer as semisynthetic derivative of the Chelidonium majus L.
Plasswilm Ludwig +10 more
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Identification of potential bioactive phytochemicals for the inhibition of platelet-derived growth factor receptor β: a structure-based approach for cancer therapy [PDF]
Frontiers in Molecular BiosciencesPlatelet-derived growth factor receptor beta (PDGFRβ) belongs to the receptor tyrosine kinase (RTK) protein family and is implicated in several disorders such as hematopoietic, glial, and soft-tissue cancer, non-cancerous disorders, including skeletal ...
Insan Habib +8 more
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Structure-Based Virtual Screening of Potential Inhibitors Targeting the Prolyl-tRNA Synthetase (PRS) in Eimeria tenella: Insights from Molecular Docking, ADMET Studies, and Molecular Dynamics Simulations [PDF]
MoleculesAvian coccidiosis, caused by protozoan parasites of the genus Eimeria, poses a major threat to the poultry industry worldwide, leading to severe economic losses through reduced growth rates, poor feed efficiency, and increased mortality.
Haiming Cai +10 more
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Modulatory Effect of Chelidonium majus Extract and Its Alkaloids on LPS-Stimulated Cytokine Secretion in Human Neutrophils [PDF]
Molecules, 2020 Due to certain differences in terms of molecular structure, isoquinoline alkaloids from Chelidonium majus engage in various biological activities.
Sylwia Zielińska +7 more
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Molecules, 2016 Alkaloids, the largest group among the nitrogen-containing secondary metabolites of plants, usually interact with several molecular targets. In this study, we provide evidence that six cytotoxic alkaloids (sanguinarine, chelerythrine, chelidonine ...
Xiaojuan Wang +4 more
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Unveiling potential diagnostic biomarkers for rheumatoid arthritis through integrated gene expression analysis [PDF]
Frontiers in ImmunologyObjectiveRheumatoid arthritis (RA) is a chronic autoimmune disorder that significantly impacts quality of life. Despite extensive research, its pathogenesis remains unclear.
Zhi-wei Feng +8 more
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