Results 11 to 20 of about 1,235 (206)

Preparation of chelidonine highly loaded poly(lactide-co-glycolide)-based nanoparticles using a single emulsion method: Cytotoxic effect on MDA-MB-231 cell line [PDF]

Journal of HerbMed Pharmacology, 2022
Introduction: Chelidonine, a bio-active component of Chelidonium majus, has been investigated for its anti-proliferative effects on various cancer cell lines with multidrug resistance (MDR).
Zahra Hamidia, Kahin Shahanipour, Nasrin Talebian, Ramesh Monajemi   +3 more
doaj   +2 more sources

Opposing Effects of Chelidonine on Tyrosine and Serine Phosphorylation of STAT3 in Human Uveal Melanoma Cells [PDF]

International Journal of Molecular Sciences, 2021
STAT3 is a transcription factor that regulates various cellular processes with oncogenic potential, thereby promoting tumorigenesis when activated uncontrolled.
Peter Nagy, István Rebenku, Tamás Kovacs   +2 more
exaly   +3 more sources

Telomere shortening in breast cancer cells (MCF7) under treatment with low doses of the benzylisoquinoline alkaloid chelidonine. [PDF]

PLoS ONE, 2018
Telomeres, the specialized dynamic structures at chromosome ends, regularly shrink with every replication. Thus, they function as an internal molecular clock counting down the number of cell divisions. However, most cancer cells escape this limitation by
Sakineh Kazemi Noureini, Leili Fatemi, Michael Wink   +2 more
doaj   +2 more sources

Screening of Chelidonium majus isoquinoline alkaloids reveals berberine and chelidonine as selective ligands for the nuclear receptors RORβ and HNF4α, respectively

Archiv der Pharmazie, Volume 357, Issue 7, July 2024.
Since the Chelidonium majus (greater celandine) alkaloid sanguinarine has recently been characterized as a dual peroxisome proliferator‐activated receptor‐α/γ ligand, sanguinarine and structurally related alkaloids were screened on nuclear receptors. Berberine and chelidonine were identified as Chelidonium majus alkaloids with selectivity for the two ...
Sohrab Salehi, Espen Schallmayer, Nils Bandomir, Annette Kärcher, Jan‐Frederik Güth, Pascal Heitel   +5 more
wiley   +2 more sources

Sanguinarine and Chelidonine Synergistically Induce Endosomal Toll-like Receptor and M1-Associated Mediators Expression

Journal of Pure and Applied Microbiology, 2020
Natural compounds represent the great capability to stimulate several cell types. Macrophage plays an important role for an effective immune response for infection and inflammation.
Nuchsupha Sunthamala, Chutimun Suebsamran, Niramon Khruaphet, Neeranuch Sankla, Janchai Janpirom, Surasak Khankhum, Rungruedee Thiwthong, Sununta Chuncher   +7 more
doaj   +2 more sources

Chelidonine Induces Caspase‐Dependent and Caspase‐Independent Cell Death through G2/M Arrest in the T98G Human Glioblastoma Cell Line

Evidence-Based Complementary and Alternative Medicine, Volume 2019, Issue 1, 2019., 2019
Chelidonium majus L. (family Papaveraceae), commonly known as greater celandine or tetterwort, has been reported to have antibacterial and anticancer effects and chelidonine is known as a functional metabolite extracted from C. majus. In this study, we observed the cytotoxicity of the alkaloid, chelidonine, and investigated its functional mechanism in ...
Yeon-Kyeong Lee, Ki Won Lee, Minju Kim, Yerin Lee, Jiyun Yoo, Cheol Hwangbo, Ki Hun Park, Kwang Dong Kim, Luciana Dini   +8 more
wiley   +2 more sources

Effects of endophytic fungus Y118 on physiological and biochemical indexes and quality improvement of Zanthoxylum Nitidum (Roxb.) DC [PDF]

Scientific Reports
To understand the effects of endophytic fungus Y118 on the physiological characteristics of Zanthoxylum nitidum (Roxb.) DC after co-culture with its host Zanthoxylum nitidum, we measured the plant growth index (dry root weight) of Zanthoxylum nitidum at ...
Zebi Xie, Rong Fan, Kaiping Lai, Zining Liang, Ning Song, Long Chen, Chunfeng Wu   +6 more
doaj   +2 more sources

Genetic insights into alcohol-associated liver disease: integrative transcriptome-wide analysis identifies novel susceptibility genes [PDF]

Frontiers in Medicine
BackgroundAlcohol-associated liver disease (ALD) is a chronic condition influenced by both genetic and environmental factors. While GWAS has identified ALD-related loci (PNPLA3, MBOAT7, TM6SF2), underlying genetic mechanisms and therapeutic targets ...
Qianchang Wang, Zhe Wang, Minzhe Hu, Fangfeng Liu, Fangfeng Liu, Zhengjian Wang   +5 more
doaj   +2 more sources

Chelidonine and Homochelidonine Induce Cell Death through Cell Cycle Checkpoints and MAP Kinase Pathways

Natural Product Communications, 2017
This study focuses on the comparative in vitro cytotoxicity of chelidonine and homochelidonine on human cancer and non-cancer cells. Both alkaloids produced a decrease in cellular growth in a dose-dependent manner exhibiting greater potency in cancer ...
Radim Havelek, Martina Seifrtova, Karel Kralovec, Klara Habartova, Lucie Cahlikova, Martina Rezacova   +5 more
doaj   +2 more sources

Biological Activities of Some Isoquinoline Alkaloids from Fumaria schleicheri Soy. Will. [PDF]

Plants, 2022
Fumaria schleicheri Soy. Will. is a species belonging to the Papaveraceae family, being widespread in East-Central and Southern Europe. As with numerous other species of the genus, it is used in traditional medicine for the treatment of hepatobiliary and
Ramona Păltinean, Irina Ielciu, Daniela Hanganu, Mihaela Niculae, Emoke Pall, Luc Angenot, Monique Tits, Andrei Mocan, Mihai Babotă, Oleg Frumuzachi, Mircea Tămaş, Gianina Crişan, Michel Frederich   +12 more
doaj   +2 more sources