Results 141 to 150 of about 1,235 (206)

Profiling the Complexity of Resistance Factors in Cancer Cells Towards Berberine and Its Derivatives. [PDF]

Pharmaceuticals (Basel)
Özenver N, T Ali N, Yücer R, Lei X, Bringmann G, Efferth T, Dawood M.   +6 more
europepmc   +1 more source

Recent Advances in Alkaloids from Papaveraceae in China: Structural Characteristics and Pharmacological Effects. [PDF]

Molecules
Zhang M, Yang J, Sun Y, Kuang H.
europepmc   +1 more source

[Partition of chelidonine and protopine by means of countercurrent cascade extraction].

Acta poloniae pharmaceutica, 1998
L, JUSIAK, E, SOCZEWINSKI, A, WAKSMUNDZKI   +2 more
openaire   +1 more source

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Cytotoxicity and apoptotic signalling cascade induced by chelidonine-loaded PLGA nanoparticles in HepG2 cells in vitro and bioavailability of nano-chelidonine in mice in vivo

Toxicology Letters, 2013
Poor oral bioavailability of chelidonine, a bio-active ingredient of Chelidonium majus, showing anti-cancer potentials against cancer cells with multidrug resistance, makes its optimal use rather limited. To address this problem, we encapsulated chelidonine in biodegradable poly(lactide-co-glycolide) (PLGA) polymers and evaluated nano-chelidonine's ...
Avijit Paul, Sreemanti Das, Jayeeta Das   +2 more
exaly   +4 more sources

In vitro and in vivo studies of the metabolic activation of chelidonine

Chemico-Biological Interactions, 2019
Chelidonium majus L. is a herbal medicine widely employed in Europe and Western Asia. Chelidonine (CHE) is a major constituent of the herb and has been reported to be an inhibitor of the cytochrome P450 enzymes (CYP). The major objective of the present study was to study the metabolic pathways of CHE in order to identify potential reactive metabolites ...
Yuyang Liu, Ying Peng, Zhengyu Zhang, Xiucai Guo, Mingshan Ji, Jiang Zheng   +5 more
openaire   +3 more sources

Mechanism‐based inactivation of cytochrome P450 2D6 by chelidonine

Journal of Biochemical and Molecular Toxicology, 2018
AbstractChelidonine (CHE) is a major bioactive constituent of greater celandine, a plant used in traditional herbal medicines. CHE has widely been used as an analgesic in clinical settings. We evaluated the inhibitory effects of CHE on human cytochrome P450 enzymes.
Yuyang Liu, Tiantian Cui, Ying Peng, Mingshan Ji, Jiang Zheng   +4 more
openaire   +3 more sources

Solution conformation of the alkaloid chelidonine and its protonated form

Magnetic Resonance in Chemistry, 2000
The solution conformation of the alkaloid chelidonine in CDCl3 was studied by proton steady-state NOE and DPFGSE NOE techniques. The experiments showed that the molecule adopts in solution essentially the same conformation as in the crystal state. Upon protonation with trifluoroacetic acid in CDCl3 chelidonine preserves its conformation, although a ...
Lech Kozerski, Grzegorz Grynkiewicz, Elżbieta Bednarek   +2 more
exaly   +2 more sources

Chelidonine selectively inhibits the growth of gefitinib-resistant non-small cell lung cancer cells through the EGFR-AMPK pathway

Pharmacological Research, 2020
Tyrosine kinase inhibitors (TKIs) have been widely used for the clinical treatment of patients with non-small cell lung cancer (NSCLC) harboring mutations in the EGFR.
Ya-Jia Xie, Qibiao Wu, Xiaojun Yao
exaly   +2 more sources

Chelidonine

2018
Jia-Lin Sun, Li-Da Du, Guan-Hua Du
exaly   +2 more sources

Chelidonine from symphoricarpos albus

Phytochemistry, 1978
J David Phillipson
exaly   +2 more sources