Results 161 to 170 of about 1,235 (206)

Chelidonine-induced inhibition of FBP1 disrupts M2 macrophage polarization and attenuates breast cancer.

Phytomedicine
BACKGROUND Chelidonium majus l., a traditional herbal medicine listed in the Pharmacopoeia of China (2025), has remarkable anticancer properties. Chelidonine (CHE), its primary bioactive alkaloid, can inhibit the proliferation of breast cancer (BC) cells;
Kaili Liu, Jianli Li, Zhiwei Sun, Yuheng Sun, Xuerui Zhang, Yang Sui, Zhongyuan Qu, Xiang Zou   +7 more
semanticscholar   +1 more source

Activation of the Tp53 Apoptosis Signaling Pathway by Chelidonine Induces Cardiac Developmental Abnormalities in Zebrafish Larvae.

Chemico-Biological Interactions
Chelidonium majus L. (C. majus) is a notable medicinal plant, esteemed for its antispasmodic and analgesic properties. The principal bioactive compound, chelidonine, acts similarly to morphine as an anesthetic analgesic and inhibits tumor growth by ...
Jin Gu, Yanwen Zheng, Jian Su, Rui Li, Chiyu Zhang, Han Wang, Zhaomin Zhong   +6 more
semanticscholar   +1 more source

Design, synthesis and apoptosis-related antiproliferative activities of chelidonine derivatives.

Bioorganic & Medicinal Chemistry Letters, 2019
To get chelidonine derivatives with enhanced antiproliferative activity and selectivity, a series of nitric oxide donating derivatives (10a-f and 11a-j) were designed, synthesized and biologically evaluated.
Xue-Yan Huang, Keguang Cheng, Lilin Liu, Xu Hu, Xiang Gao, Haonan Li, Fanxing Xu, Zhanlin Li, H. Hua, Dahong Li   +9 more
semanticscholar   +1 more source

Poly (lactide-co-glycolide) nano-encapsulation of chelidonine, an active bioingredient of greater celandine (Chelidonium majus), enhances its ameliorative potential against cadmium induced oxidative stress and hepatic injury in mice

Environmental Toxicology and Pharmacology, 2013
Avijit Paul, Jayeeta Das, Sreemanti Das   +2 more
exaly   +2 more sources

The Solid‐State and Solution Conformations of (+)‐Chelidonine

Helvetica Chimica Acta, 1990
AbstractThe solid‐state and solution conformations of (+)‐chelidonine (1), a biologically active alkaloid, were determined by X‐ray diffraction and 1H‐NMR spectroscopy, X‐Ray diffraction analysis revealed a conformer with B/C ‘anti‐type’ cis conjunction, a half‐chair of ring B, and a twist half‐chair of ring C.
Miyoko Kamigauchi, Yuko Miyamoto, Kinuko Iwasa, Makiko Sugiura, Zjujiro Nishijo, Narao Takao, Toshimasa Ishida, Yasuko In, Masatoshi Inoue   +8 more
openaire   +1 more source

ChemInform Abstract: TOTALSYNTHESE VON DL‐CHELIDONIN

Chemischer Informationsdienst. Organische Chemie, 1971
AbstractBei Umsetzung des Na‐Salzes des Urethans (I) mit dem Benzylbromid (II) in Gegenwart von NaJ entsteht das Styrol (IIIa), das durch Bromierung und anschließende Behandlung mit K‐tert.‐butoxid und 1,5‐Diaza‐bicyclo[5 .4.0]undecen‐(5) in Hexamethylphosphorsäureamid in das Acetylen (IIIb) umgewandelt wird.
W. OPPOLZER, K. KELLER
openaire   +1 more source

ChemInform Abstract: Crystal and Molecular Structure of Chelidonine

ChemInform, 1991
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
B. RIBAR, A. KAPOR, C. MEZSAROS, O. GASIC, P. ENGEL   +4 more
openaire   +1 more source

Absolute configuration and chiroptical properties of chelidonine and tetrahydroberberine alkaloids

Tetrahedron, 1970
Abstract The CD within the 1 L b band of tetrahydroberberine alkaloids is rationalized with the aid of a rule taking into account the chirality of the second sphere, a sector rule for third (fourth, …) sphere contributions. Extension to the 1 L a , band CD is proposed.
G. Snatzke, J. Hrbek, L. Hruban, A. Horeau, F. Šantavý   +4 more
openaire   +1 more source

Preliminary pharmacological evaluation of chelidonine in rodents.

Polish journal of pharmacology and pharmacy, 1990
Our studies showed that the chelidonine administered intraperitoneally (ip) exerted an inhibitory effect on the central nervous system of the rodents. It was shown that chelidonine depressed the spontaneous and explorative motor activities, decreased body temperature, potentiated the action of hypnotics and increased sedation in reserpinized mice ...
E, Jagiełło-Wójtowicz, L, Jusiak, J, Szponar, Z, Kleinrok   +3 more
openaire   +1 more source

Separation and Determination of the Dissociation Constants of Chelidonine and Protopine by Paper Chromatography

Nature, 1958
IN connexion with the chromatographic separation of alkaloids of Chelidonium maius L.1, I found alkaloids giving rather big spots with a tendency to form tails. This is connected, among other things, with the dissociation constant (K B), the value of which influences the course of the chromatographic process, organic electrolytes having different ...
openaire   +2 more sources