Results 131 to 140 of about 226,393 (319)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

The First Chemical Census of the Milky Way’s Nuclear Star Cluster

The Astrophysical Journal Letters
An important step in understanding the formation and evolution of the nuclear star cluster (NSC) is to investigate its chemistry and chemical evolution. Additionally, exploring the NSC’s relationship to the other structures in the Galactic center and the
Govind Nandakumar, Nils Ryde, Mathias Schultheis, R. Michael Rich, Paola di Matteo, Brian Thorsbro, Gregory Mace   +6 more
doaj   +1 more source

Gaia FGK benchmark stars: Spectral library and abundances of α and Fe-peak elements of the third version

Astronomy & Astrophysics
Context. Accurate determination of the chemical abundances in stars plays a pivotal role in understanding stellar structure and evolution, nucleosynthesis, and the chemical enrichment history of the Milky Way.
Casamiquela L., Soubiran C., Jofré P., Vitali S., Blanco-Cuaresma S., Lagarde N., Slumstrup D., Heiter U., Palmerio J. T., Brouillet N., Elgueta S., Rojas–Arriagada A., Aguilera–Gómez C., Hernández–Araya I., Creevey O. L., Balaguer–Núñez L., Carrera R.   +16 more
doaj   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Tracking the Chemical Evolution of Hydrocarbons Through Carbon Grain Supply in Protoplanetary Disks

The Astrophysical Journal
The gas present in planet-forming disks typically exhibits strong emission features of abundant carbon and oxygen molecular carriers. In some instances, protoplanetary disks show an elevated C/O ratio above interstellar values, which leads to a rich ...
Eshan Raul, Felipe Alarcón, Edwin A. Bergin   +2 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

What Can We Learn from the Nitrogen Abundance of High-z Galaxies?

The Astrophysical Journal
We present measurements of the gas-phase oxygen and nitrogen abundances obtained by applying the direct method to JWST NIRspec R  ∼ 1000 spectroscopy for six galaxies at redshift greater than 3.
Massimo Stiavelli, Takahiro Morishita, Marco Chiaberge, Nicha Leethochawalit, Colin Norman, Massimo Ricotti, Guido Roberts-Borsani, Tommaso Treu, Eros Vanzella, Rosemary F. G. Wyse, Yechi Zhang, Kit Boyett   +11 more
doaj   +1 more source

Chemical abundances of the LMC cluster Hodge 11 and its surrounding field [PDF]

, 2009
Renee Mateluna, D. Geisler, S. Villanova
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source