Results 151 to 160 of about 226,393 (319)

Analysis of the Internal Radial Gradient of Chemical Abundances in Spiral Galaxies from CALIFA

open access: yesThe Astrophysical Journal
The study of chemical evolution is of paramount importance for understanding the evolution of galaxies. Models and observations propose an inside-out mechanism in the formation of spiral galaxy disks, implying a negative radial gradient of elemental ...
A. F. S. Cardoso   +3 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

Optical Spectroscopy Reveals Hidden Neutron-capture Elemental Abundance Differences among APOGEE-identified Chemical Doppelgängers

open access: yesThe Astrophysical Journal
Grouping stars by chemical similarity has the potential to reveal the Milky Way’s evolutionary history. The APOGEE stellar spectroscopic survey has the resolution and sensitivity for this task.
Catherine Manea   +11 more
doaj   +1 more source

The Sixth Data Release of the Radial Velocity Experiment (Rave). II. Stellar Atmospheric Parameters, Chemical Abundances, and Distances [PDF]

open access: bronze, 2020
Matthias Steinmetz   +61 more
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

The Open Cluster Chemical Abundances and Mapping Survey. VIII. Galactic Chemical Gradient and Azimuthal Analysis from SDSS/MWM DR19

open access: yesThe Astronomical Journal
The Open Cluster Chemical Abundances and Mapping (OCCAM) survey seeks to curate a large, comprehensive, uniform dataset of open clusters and member stars to constrain key Galactic parameters.
Jonah M. Otto   +20 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Home - About - Disclaimer - Privacy