Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
Chemical Risk Factors of Primary Liver Cancer: An Update
Hepatic Medicine: Evidence and Research, 2021 Adam Barsouk,1 Krishna Chaitanya Thandra,2 Kalyan Saginala,3 Prashanth Rawla,4 Alexander Barsouk5 1Sidney Kimmel Cancer Center, Jefferson University, Philadelphia, PA 19107, USA; 2Department of Pulmonary and Critical Care Medicine, Sentara Virginia Beach
Barsouk A +4 more
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[(η5-pentamethylcyclopentadienyl)(3-fluoro-N-methylbenzylamine-к1,N)dichlorido]iridium(III)
Molbank, 2018 A half-sandwich iridium(III) complex containing 3-fluoro-N-methylbenzylamine ligands has been obtained by reaction of one equivalent of [(η5-Cp*)IrCl2]2 (Cp* = pentamethylcyclopentadienyl) with two equivalent of 3-fluoro-N-methylbenzylamine in very ...
Deliang Kong +4 more
doaj +1 more source
A Multiagent-Driven Robotic AI Chemist Enabling Autonomous Chemical Research On Demand.
Journal of the American Chemical SocietyThe successful integration of large language models (LLMs) into laboratory workflows has demonstrated robust capabilities in natural language processing, autonomous task execution, and collaborative problem-solving. This offers an exciting opportunity to
Tao Song +15 more
semanticscholar +1 more source
Chemical weapons disposal program [PDF]
The Department of Defense (DoD) is in the process of destroying the entire U.S. stockpile of aging and obsolete chemical weapons. The original stockpile contained 63 million pounds of chemical weapons disseminated at eight sites in the continental United
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Threat of non-traditional agents: a new frontier in chemical weapons concerns?
The development and use of chemical and toxin-based weapons have evolved significantly over time, from early historical applications to modern incidents involving highly potent agents.
Guerra Guirao, José Antonio +3 more
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Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease
FEBS Letters, EarlyView.Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim +4 more
wiley +1 more source
Interim recommendations for airborne exposure limits for chemical warfare agents H and HD (sulfur mustard) [PDF]
SUMMARY: Agents H and HD are stored and are being destroyed by the Department of Defense (DoD). Public Law 99\u2013145 (50 U.S.C. 1521) mandates that the Secretary of Defense carry out the destruction of the United States\u2019 stockpile of lethal ...
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AN EXPERIMENTAL MODEL OF ESOPHAGUS AND STOMACH CHEMICAL BURN WITH MODERN AGGRESSIVE CHEMICAL AGENTS [PDF]
, 2012 Aim of the research: to explore the model of esophagus and stomach chemical burn with modern chemical agents in the experiment on animals. The article presents the results of experimental research of chemical burn of the esophagus in Vistar rats.
A. N. Plekhanov +3 more
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source