Results 91 to 100 of about 767,411 (260)

More than tears: associations between exposure to chemical agents used by law enforcement and adverse reproductive health outcomes. [PDF]

Front Epidemiol, 2023
Hassan A, Ojanen-Goldsmith A, Hing AK, Mahoney M, Traxler S, Boraas CM.   +5 more
europepmc   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

The dangerous link between coal dust exposure and DNA damage: unraveling the role of some of the chemical agents and oxidative stress. [PDF]

Environ Geochem Health, 2023
Miranda-Guevara A, Muñoz-Acevedo A, Fiorillo-Moreno O, Acosta-Hoyos A, Pacheco-Londoño L, Quintana-Sosa M, De Moya Y, Dias J, de Souza GS, Martinez-Lopez W, Garcia ALH, da Silva J, Borges MS, Henriques JAP, León-Mejía G.   +14 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

An experimental study to measure oil recovery factor by chemical agents and carbon dioxide after waterflooding. [PDF]

Sci Rep, 2022
Yang G, Bai Y, Song Y, Metwally ASM, Mahmoud O.   +4 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Impediment effect of chemical agents (additives) on gluten development in cookie dough. [PDF]

J Food Sci Technol, 2022
Ahmad S, Naz A, Usman M, Amjad A, Pasha I, Farooq U.   +5 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Macrophages bend long fibres with flexural rigidity lower than 3 mN·nm2 to avoid frustrated phagocytosis

Particle and Fibre Toxicology
Background It is an established toxicological principle that the inhalation pathogenicity of respirable and biodurable fibres is caused by excessive fibre length as alveolar macrophages fail to uptake and remove such fibres.
Dirk Broßell, Asmus Meyer-Plath, Oliver Gräb, Elisabeth Heunisch, Kerstin Kämpf, Andrea Haase, Martin Wiemann   +6 more
doaj   +1 more source

Modeling the dynamic kinetics of microbial disinfection with dissipating chemical agents-a theoretical investigation. [PDF]

Appl Microbiol Biotechnol, 2021
Peleg M.
europepmc   +1 more source